Results 41 to 50 of about 10,369 (237)

Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia[S] [PDF]

Journal of Lipid Research, 2017
Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD.
Hiten D. Mistry, Lesia O. Kurlak, Yosef T. Mansour, Line Zurkinden, Markus G. Mohaupt, Geneviève Escher   +5 more
doaj   +5 more sources

Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison

Journal of Steroid Biochemistry and Molecular Biology, 2023
Julen Goikolea, María Latorre‐Leal, Christina Tsagkogianni, Sonja Pikkupeura, Balázs Gulyás, Ángel Cedazo-Mı́nguez, Raúl Loera‐Valencia, Ingemar Björkhem, Patricia Rodriguez‐Rodriguez, Silvia Maioli   +9 more
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Expression of Sterol 27-Hydroxylase (CYP27A1) Enhances Cholesterol Efflux [PDF]

Journal of Biological Chemistry, 2003
Cholesterol efflux from CHOP cells transfected with sterol 27-hydroxylase (CYP27A1) was compared with non-transfected and mock-transfected cells. Transfection caused expression of CYP27A1, formation of 27-hydroxycholesterol, and inhibition of cholesterol biosynthesis. Transfection enhanced cholesterol efflux to apolipoprotein A-I or human plasma by 2-3-
Geneviève Escher, Zygmunt S. Krozowski, Kevin D. Croft, Dmitri Sviridov   +3 more
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Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer [PDF]

Endocrine-Related Cancer, 2017
The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1 expression on pathobiology and clinical response to statins in breast cancer needs clarification. 27HC is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis.
Siker Kimbung, Ching‐yi Chang, Pär‐Ola Bendahl, Laura G. Dubois, J. Will Thompson, Donald P. McDonnell, Signe Borgquist   +6 more
openalex   +3 more sources

Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE‐knockout mice

The FASEB Journal, 2013
In humans, sterol 27‐hydroxylase (CYP27A1) deficiency leads to cholesterol deposition in tendons and vasculature. Thus, in addition to its role in bile acid synthesis, where it converts cholesterol to 27‐hydroxycholesterol (27‐OHC), CYP27A1 may also be atheroprotective. Cyp27A1‐deficient ( Cyp27A1
Line Zurkinden, Curzio Solcà, Isabelle Vögeli, Bruno Vogt, Daniel Ackermann, Sandra K. Erickson, Felix J. Frey, Dmitri Sviridov, Geneviève Escher   +8 more
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Hepatic caveolin‐1 is enhanced in Cyp27a1/ApoE double knockout mice [PDF]

FEBS Open Bio, 2016
Sterol 27‐hydroxylase (CYP27A1) is involved in bile acid synthesis and cholesterol homoeostasis. Cyp27a1(−/−)/Apolipoprotein E(−/−) double knockout mice (DKO) fed a western diet failed to develop atherosclerosis. Caveolin‐1 (CAV‐1), the main component of caveolae, is associated with lipid homoeostasis and has regulatory roles in vascular diseases.
Line Zurkinden, Yosef T. Mansour, Beatrice Rohrbach, Bruno Vogt, Hiten D. Mistry, Geneviève Escher   +5 more
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Information Theory Analysis of CTX Shows Consistent Clinical Presentation. [PDF]

J Inherit Metab Dis
ABSTRACT Cerebrotendinous xanthomatosis (CTX) is a rare, metabolic disorder caused by pathogenic variants in CYP27A1. The classic clinical presentation includes infantile‐onset chronic diarrhea, juvenile‐onset bilateral cataracts, with development of tendon xanthomas and progressive neurological dysfunction.
Hanson J, Bonnen PE.
europepmc   +2 more sources

Molecular cloning, expression analysis and functional characterization of chicken cytochrome P450 27A1: A novel mitochondrial vitamin D3 25-hydroxylase

Poultry Science, 2023
: Vitamin D3 is hydroxylated by cytochrome P450 (CYP) before exerting biological effects. The chicken CYP involved in vitamin D3 25-hydroxylation has yet to be cloned, and little is known about its functional characteristics, tissue distribution, and ...
S. Shang, Z. He, W. Hou, X. Chen, X. Zhao, H. Han, S. Chen, S. Yang, F. Tai   +8 more
doaj   +1 more source

Data from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer

, 2023
<div>Abstract<p>In this study, we used a bioinformatic approach to identify genes whose expression is dysregulated in human prostate cancers. One of the most dramatically downregulated genes identified encodes CYP27A1, an enzyme involved in regulating cellular cholesterol homeostasis.
Mahmoud A. Alfaqih, Erik R. Nelson, Wen Liu, Rachid Safi, Jeffery S. Jasper, Everardo Macias, Joseph Geradts, J. Will Thompson, Laura G. Dubois, Marc Freeman, Ching‐yi Chang, Jen‐Tsan Chi, Donald P. McDonnell, Stephen J. Freedland   +13 more
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Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS [PDF]

PLoS ONE, 2012
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease characterized by loss of upper and lower motor neurons. ALS is considered to be a complex trait and genome-wide association studies (GWAS) have implicated a few susceptibility loci. However, many more causal loci remain to be discovered. Since it has been shown that genetic
Frank P. Diekstra, Christiaan G. J. Saris, Wouter van Rheenen, Lude Franke, Ritsert C. Jansen, Michael A. van Es, Paul W.J. van Vught, Hylke M. Blauw, Ewout J. N. Groen, Steve Horvath, Karol Estrada, Fernando Rivadeneira, Albert Hofman, André G. Uitterlinden, Wim Robberecht, Peter M. Andersen, Judith Melki, Vincent Meininger, Orla Hardiman, John E. Landers, Robert H. Brown, Aleksey Shatunov, Christopher E. Shaw, P. Nigel Leigh, Ammar Al‐Chalabi, Roel A. Ophoff, Leonard H. van den Berg, Jan H. Veldink   +27 more
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