Results 1 to 10 of about 8,876 (157)

Identifying metabolism-related genes in liver cancer through weighted gene co-expression network analysis and machine learning [PDF]

Frontiers in Genetics
ObjectiveAs a leading cause of cancer-related mortality, liver cancer was associated with metabolic dysregulation. We aimed to identify metabolism-related prognostic biomarkers and therapeutic targets.MethodsTranscriptomic data from TCGA were analyzed ...
Taorui Wang, Zijun Lai, Shengjun Tang, Lehang Lin, Mingjiao Zhang   +4 more
doaj   +2 more sources

Evaluation of CYP2C8 and CYP2C9 Polymorphisms in Neonates with Patent Ductus Arteriosus Treated with Ibuprofen or Indomethacin: A Retrospective Cohort Study [PDF]

Journal of Cardiovascular Development and Disease
The pharmacologic management of patent ductus arteriosus (PDA) presents a challenge to clinicians due to the interindividual variability in drug response to available medications.
Shaikha Jabor Alnaimi, Shimaa Aboelbaha, Ibrahim Safra, Mai Abdulla Al Qubaisi, Fouad Abounahia, Ahmed Al Farsi, Liji Cherian, Lizy Philip, Moza Alhail, Gulab Sher, Nader Al-Dewik   +10 more
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Improving the accuracy of prediction models for small datasets of Cytochrome P450 inhibition with deep learning [PDF]

Journal of Cheminformatics
The cytochrome P450 (CYP) superfamily metabolises a wide range of compounds; however, drug-induced CYP inhibition can lead to adverse interactions. Identifying potential CYP inhibitors is crucial for safe drug administration.
Elpri Eka Permadi, Reiko Watanabe, Kenji Mizuguchi   +2 more
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CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups

Терапевтический архив, 2021
Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks. Materials and methods.
Sherzod P. Abdullaev, Natalia P. Denisenko, Karin B. Mirzaev, Gregorii N. Shuev, Zhannet A. Sozaeva, Anastasia A. Kachanova, Suleiman N. Mammaev, Elvira A. Kasaeva, Danial M. Gafurov, Elena A. Grishina, Dmitry A. Sychev   +10 more
doaj   +1 more source

Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

Malaria Journal, 2021
Background The anti-malarial drug, amodiaquine, a commonly used, long-acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8).
Leyre Pernaute-Lau, Ulrika Morris, Mwinyi Msellem, Andreas Mårtensson, Anders Björkman, Jose Pedro Gil   +5 more
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Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome

Терапевтический архив, 2022
Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain. Materials and methods.
Andranik A. Muradian, Dmitry A. Sychev, Dmitry A. Blagovestnov, Demyan I. Petrov, Dmitry S. Skukin, Irina P. Epifanova, Zhannet A. Sozaeva, Anastasia A. Kachanova, Natalia P. Denisenko, Sherzod P. Abdullaev, Elena A. Grishina   +10 more
doaj   +1 more source

Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges

Biomolecules, 2022
The lipid-regulating drug gemfibrozil is a useful medication for reducing high cholesterol and triglycerides in the blood. In addition to oxidation, it undergoes extensive glucuronidation to produce gemfibrozil acyl glucuronide, which is a known ...
Manish B. Shah
doaj   +1 more source

Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles

Pharmaceutical Biology, 2022
Context As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food.
Shun-bin Luo, Er-min Gu, Yu-ao Chen, Shi-chen Zhou, Chen Fan, Ren-ai Xu   +5 more
doaj   +1 more source

Structure of the distribution of genetic determinants of the efficacy and safety of non-steroidal anti-inflammatory drugs in the Russian population: focus on CYP2C8, PTGS1 and PTGS2

Современная ревматология, 2022
The efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) may be determined by the polymorphic nature of the CYP2C8, PTGS1 and PTGS2 genes.Objective: to analyze the nature of the distribution of CYP2C8*3 (rs10509681), CYP2C8*3 (rs11572080)
N. P. Denisenko, Sh. P. Abdullaev, K. A. Akmalova, Zh. A. Sozaeva, A. A. Kachanova, M. S-Kh. Sozaeva, L. Z. Bolieva, E. A. Grishina, D. A. Sychev   +8 more
doaj   +1 more source

Distribution of the cytochrome P450 CYP2C8*2 allele in Brazzaville, Republic of Congo

International Journal of Infectious Diseases, 2019
Background: Cytochrome P450 (CYP) enzymes are essential in the metabolism of most drugs used today. Single nucleotide polymorphism(s) occurring in CYP genes can adversely affect drug pharmacokinetics, efficacy, and safety. Individuals carrying the CYP2C8*
Simon Marie Peko, Francine Ntoumi, Christevy Vouvoungui, David Nderu, Simon Charles Kobawila, Thirumalaisamy P. Velavan, Félix Koukouikila-Koussounda   +6 more
doaj   +1 more source