Results 11 to 20 of about 8,876 (157)

Genetic polymorphism of CYP2C8*4 in a healthy Turkish population [PDF]

Medicine Science, 2020
Cytochrome P4502C8 (CYP2C8) is a significant member of CYP enzyme family and metabolizes about 20% of commonly prescribed drugs and endogenous compounds.
Zuhal Uckun Sahinogullari
doaj   +11 more sources

CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride

Clinical and Translational Science, 2022
Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease.
Diana María Campodónico, Pablo Zubiaur, Paula Soria‐Chacartegui, Ana Casajús, Gonzalo Villapalos‐García, Marcos Navares‐Gómez, Antía Gómez‐Fernández, Raúl Parra‐Garcés, Gina Mejía‐Abril, Manuel Román, Samuel Martín‐Vílchez, Dolores Ochoa, Francisco Abad‐Santos   +12 more
doaj   +5 more sources

Managing Drug-Drug Interactions Involving the Non-Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and intestinal efflux by P‐glycoprotein (P‐gp).
Zhou Z, Ainslie GR, Li M, Dinh J, Zamek-Gliszczynski MJ, Zhao P, Paine MF.   +6 more
europepmc   +2 more sources

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans. [PDF]

Clin Pharmacol Ther
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Aurinsalo L, Lapatto-Reiniluoto O, Kurkela M, Neuvonen M, Moilanen E, Niemi M, Tornio A, Backman JT.   +7 more
europepmc   +2 more sources

Amiodarone N‐Deethylation by CYP2C8 and its Variants, CYP2C8*3 and CYP2C8 P404A [PDF]

Pharmacology & Toxicology, 2002
Abstract: Amiodarone is a potent Class III antiarrhythmic drug. The N‐deethylation of amiodarone to desethylamiodarone is known to be catalyzed by cytochrome P450 (CYP) 2C8. In the present study, amiodarone N‐deethylation by the CYP2C8s, CYP2C8*1 (wild‐type), CYP2C8*3, and CYP2C8 P404A (Pro404Ala substitution in exon 8), was investigated by their ...
Akiko, Soyama, Nobumitsu, Hanioka, Yoshiro, Saito, Norie, Murayama, Masanori, Ando, Shogo, Ozawa, Jun-ichi, Sawada   +6 more
openaire   +2 more sources

CYP2C8 and Antimalaria Drug Efficacy [PDF]

Pharmacogenomics, 2007
Malaria is a major infectious disease. In the last 10 years it has killed more than 20 million people, mainly small children in Africa. The highly efficacious artemisinine combination therapy is being launched globally, constituting the main hope for fighting the disease. Amodiaquine is a main partner in these combinations.
Gil, JP, Gil Berglund, E
openaire   +2 more sources

Associations between CYP2C8 rs10509681 and rs11572080 gene polymorphisms and age-related macular degeneration

Acta Medica Lituanica, 2017
Background. Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium.
Rasa Liutkevičienė, Ramunė Sungailienė, Alvita Vilkevičiūtė, Loresa Kriaučiūnienė, Paulina Vaitkienė, Romanas Chaleckis, Vytenis Pranas Deltuva   +6 more
doaj   +1 more source

The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility

Frontiers in Endocrinology, 2022
BackgroundBladder cancer is the most common leading cause of mortality around the world. Previous studies have indicated that genetic factors are significantly associated with bladder cancer progression—for instance, the CYP2C8 gene is involved in ...
Weixing Qu, Fuzhou Zhang, Yongyi Cheng, Jing Li, Jiancheng Zhou   +4 more
doaj   +1 more source

Pharmacogenetic Aspects of Type 2 Diabetes Treatment

Acta Biomedica Scientifica, 2020
In this article, we analyze the role of different variants of the KCNJ11, TCF7L2, SLC22A1, SLC22A3, CYP2C9, CYP2C8, PPARγ genes polymorphisms in efficacy of diabetes mellitus pharmacotherapy.
N. O. Pozdnyakov, I. N. Kagarmanyan, A. E. Miroshnikov, E. S. Emelyanov, A. A. Gruzdeva, A. M. Sirotkina, I. A. Dukhanina, A. A. Milkina, A. A. Khokhlov, S. O. Pozdnyakov   +9 more
doaj   +1 more source

Substrate Specificity of Human Cytochrome P450 (CYP) 2C Subfamily and Effect of Azole Antifungal Agents on CYP2C8

Journal of Pharmacy & Pharmaceutical Sciences, 2016
PURPOSE: The metabolic activities of aminopyrine N-demethylation and tolbutamide methylhydroxylation by the human hepatic cytochrome P450 (P450 or CYP) 2C subfamily were compared and the effects of azole antifungal agent on the drug-metabolizing activity
Toshiro Niwa, Yurie Imagawa
doaj   +1 more source