Results 21 to 30 of about 8,876 (157)
Pioglitazone is Metabolised by CYP2C8 and CYP3A4 in vitro: Potential for Interactions with CYP2C8 Inhibitors [PDF]
Basic & Clinical Pharmacology & Toxicology, 2006 Abstract: Our objective was to identify the cytochrome P450 (CYP) enzymes that metabolise pioglitazone and to examine the effects of the CYP2C8 inhibitors montelukast, zafirlukast, trimethoprim and gemfibrozil on pioglitazone metabolism in vitro. The effect of different CYP isoform inhibitors on the elimination of a clinically relevant concentration of
Tiina, Jaakkola +3 more
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Frontiers in Genetics, 2012 In addition to the known effects on drug metabolism and response, functional polymorphisms of genes coding for xenobiotic-metabolizing enzymes (XME) play a role in cancer.
José M Ladero +5 more
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Global variation in CYP2C8–CYP2C9 functional haplotypes [PDF]
The Pharmacogenomics Journal, 2009 We have studied the global frequency distributions of 10 single nucleotide polymorphisms (SNPs) across 132 kb of CYP2C8 and CYP2C9 in approximately 2500 individuals representing 45 populations. Five of the SNPs were in noncoding sequences; the other five involved the more common missense variants (four in CYP2C8, one in CYP2C9) that change amino acids ...
Speed, William C +4 more
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CYP2C8 and CYP2C9 mRNA expression profile in the human fetus
Frontiers in Genetics, 2014 CYP2C8 and CYP2C9 are involved in the inactivation of several NSAIDs, including ibuprofen. CYP2C9 is the major form in human liver whereas CYP2C8 has been proposed to be the main CYP2C enzyme in fetal liver.
Maria eJohansson +3 more
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Frontiers in Pharmacology, 2015 The cytochrome P450, CYP2C8, metabolises more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid.
Maria eThomas +7 more
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Biomedical Papers, 2022 Aims. Hofbauer cells (HBCs) are placental macrophages playing various roles during normal and complicated pregnancies, and of the latter, chorioamnionitis is the most frequent. Methods.
Zdenek Tauber, Katerina Cizkova
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Pharmaceutical Biology, 2022 Context Ginkgo leaf tablet (GLT), a traditional Chinese herbal formula, is often combined with rosiglitazone (ROS) for type 2 diabetes mellitus treatment. However, the drug-drug interaction between GLT and ROS remains unknown.Objective To investigate the
Xueting Xing +7 more
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CYP2C8 Exists as a Dimer in Natural Membranes [PDF]
Drug Metabolism and Disposition, 2010 CYP2C8 with a modified N-terminal sequence (2C8H) crystallizes as a dimer, but it is not known whether native CYP2C8 exists as a dimer in natural membranes. We have examined the organization of 2C8H and CYP2C8 expressed in bacterial membranes and mammalian endoplasmic reticulum membranes, respectively, by cysteine scanning and cross-linking or ...
Gang, Hu, Eric F, Johnson, Byron, Kemper
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Journal of Hepatocellular Carcinoma, 2021 Xin Zhou,1,2,* Tian-Man Li,1– 3,* Jian-Zhu Luo,1,2,* Chen-Lu Lan,1,2 Zhong-Liu Wei,1,2 Tian-Hao Fu,1,2 Xi-Wen Liao,1,2 Guang-Zhi Zhu,1,2 Xin-Ping Ye,1,2 Tao Peng1,2 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhou X +9 more
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Journal of Pharmacological Sciences, 2005 Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified.
Ryoko Taniguchi +6 more
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