Results 31 to 40 of about 8,876 (157)
Frontiers in Pharmacology, 2022 Ayurvedic medicines Withania somnifera Dunal (ashwagandha) and AYUSH-64 have been used for the prevention and management of COVID-19 in India. The present study explores the effect of Ashwagandha and AYUSH-64 on important human CYP enzymes (CYP3A4 ...
Siva Swapna Kasarla +7 more
doaj +1 more source
Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone [PDF]
Drug Metabolism and Disposition, 2016 The glucose-lowering drug pioglitazone undergoes hepatic CYP2C8-mediated biotransformation to its main metabolites. The antiplatelet drug clopidogrel is metabolized to clopidogrel acyl-β-d-glucuronide, which was recently found to be a strong time-dependent inhibitor of CYP2C8 in humans.
Tornio Aleksi +11 more
openaire +2 more sources
Effect of CYP2C8 genotype on rosiglitazone pharmacokinetics [PDF]
Clinical Pharmacology & Therapeutics, 2005 Background/Aims The purpose of this study was to investigate the effect of the CYP2C8 genetic polymorphisms CYP2C8*2, CYP2C8*3, and CYP2C8*4 on the pharmacokinetics of rosiglitazone, a PPARγ agonist and CYP2C8 substrate. Methods This single dose pharmacokinetics study involved thirty-eight healthy subjects with the following CYP2C8 ...
M HRUSKA +4 more
openaire +3 more sources
Case Reports in Medicine, 2023 Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) widely used to alleviate pain and inflammation. Although it is generally considered safe, common adverse drug reactions of ibuprofen include stomach pain, nausea, and heartburn.
Amina M. Bagher
doaj +1 more source
Pharmaceutics, 2021 Pharmaceutical excipients (PEs) are substances included in drug formulations. Recent studies have revealed that some PEs can affect the activity of metabolic enzymes and drug transporters; however, the effects of PEs on CYP2C8 and its interaction ...
Chengming Wen +5 more
doaj +1 more source
In vitro inhibitory effect of lysionotin on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2020 Context Lysionotin, a major extraction of Lysionotus pauciflorus Maxim (Gesneriaceae), has a variety of pharmacological properties commonly used in the treatment of lung disease.
Yang Li +7 more
doaj +1 more source
Effect of pterostilbene on in vitro drug metabolizing enzyme activity
Saudi Pharmaceutical Journal, 2019 Pterostilbene is a natural polyphenol compound found in small berries that is related to resveratrol, but has better bioavailability and a longer half-life.
Ahmed A. Albassam, Reginald F. Frye
doaj +1 more source
Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs
Clinical Pharmacology &Therapeutics, EarlyView.Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri +10 more
wiley +1 more source
The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients
Balkan Journal of Medical Genetics, 2016 The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment.
Milovanovic DD +7 more
doaj +1 more source
ChemistryOpen, EarlyView.This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li +6 more
wiley +1 more source