Results 71 to 80 of about 8,876 (157)

Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population

BMC Medical Genetics, 2009
Background Genetic influences on drug efficacy and tolerability are now widely known. Pharmacogenetics has thus become an expanding field with great potential for improving drug efficacy and reducing toxicity.
Dodoo Alexander NO, Kudzi William, Mills Jeremy J   +2 more
doaj   +1 more source

The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith, Danielle Graden, Lauren L. R. Lohmer, Joy Schleyer, Stephen P. Wanaski   +4 more
wiley   +1 more source

Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

PLoS ONE, 2010
BackgroundPatent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%.
Xavier Durrmeyer, Shushanik Hovhannisyan, Yves Médard, Evelyne Jacqz-Aigrain, Fabrice Decobert, Jérome Barre, Corinne Alberti, Yannick Aujard, Claude Danan, Olivier Baud   +9 more
doaj   +1 more source

In Silico Dock of TKIs with CYP3A4 and CYP2C8 and Pharmacophore Generation [PDF]

BIO Web of Conferences
Tyrosine kinase inhibitors (TKIs) serve as targeted anticancer drugs that inhibit the abnormal activity of tyrosine kinase (TK) in cancer treatment. However, when used with other medications, they often result in side effects, such as renal impairment ...
Ma Zhenya
doaj   +1 more source

Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on Cytochromes Metabolizing Hypoglycemic and Hypolipidemic Drugs

Molecules, 2016
Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of increasing concern.
Oelfah Patel, Christo Muller, Elizabeth Joubert, Johan Louw, Bernd Rosenkranz, Charles Awortwe   +5 more
doaj   +1 more source

Pharmacogenetics of non-steroidal anti-inflammatory drugs: existing problems for clinical practice

Медицинский совет, 2019
NSAIDs are the most commonly used drugs in clinical practice for pain relief in various diseases. To date, considerable scientific material has been accumulated on the pharmacogenetics of NSAIDs and the role of genetic factors that can influence the ...
M. V. Leonova, E. E. Alimova
doaj   +1 more source

Influence ofCYP2C8*13andCYP2C8*14Alleles on AmiodaroneN‐Deethylation [PDF]

Basic & Clinical Pharmacology & Toxicology, 2011
Nobumitsu, Hanioka, Kimiaki, Matsumoto, Yoshiro, Saito, Shizuo, Narimatsu   +3 more
openaire   +2 more sources

CYP2C8-Mediated Drug–Drug Interactions and the Factors Influencing the Interaction Magnitude

Drug Design, Development and Therapy
Ling-Ling Zhu,1,* Ling-Yan Yu,2,* Yan-Hong Wang,2 Quan Zhou2 1VIP Care and Geriatric Ward, Division of Nursing, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of ...
Zhu LL, Yu LY, Wang YH, Zhou Q
doaj  

Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9

Journal of Pain Research, 2017
Adriana Maria Calvo, Paulo Zupelari-Gonçalves, Thiago José Dionísio, Daniel Thomas Brozoski, Flávio Augusto Faria, Carlos Ferreira Santos Department of Biological Sciences, Bauru School of Dentistry ...
Calvo AM, Zupelari-Gonçalves P, Dionísio TJ, Brozoski DT, Faria FA, Santos CF   +5 more
doaj  

Genetic Variability of CYP2C8, CYP2C9, and CYP3A4 Across European Populations: Implications for Pharmacogenetics

Quality in Sport
 Cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins responsible for the metabolism of numerous important compounds. In humans, they are responsible for nearly 80% of oxidative reactions and approximately 50% of  total drug elimination, mainly
Karolina Borówka, Paulina Tymińska, Julia Frączek, Natlia Kawka, Grzegorz Machnik   +4 more
doaj   +1 more source