Results 141 to 150 of about 49,005 (303)

Prediction of The CYP2D6 Enzymatic Activity Based on Investigating of The CYP2D6 Genotypes Around The Vivax Malaria Patients in Yunnan Province, China [PDF]

, 2021
Ying Dong, Herong Huang, Yan Deng, Yanchun Xu, Mengni Chen, Yan Liu, Canglin Zhang   +6 more
openalex   +1 more source

Anti‐Inflammatory, Antioxidant, Molecular Docking and Pharmacokinetics Properties of Cycloeucalenone Isolated From Musa × paradisiaca L. Fruit Peels

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT This study isolated a compound with anti‐inflammatory properties from Musa × paradisiaca fruit peels. The methanol extract was partitioned, and the hexane fraction with the best bioactivity was subjected to column chromatography before characterization via Fourier transform infrared (FTIR), UV–visible (UV–VIS) and NMR analysis.
Ibeabuchi J. Ali, Kolawole A. Olofinsan, Goodnews O. Ikeh, Ndidiamaka H. Okorie, Cyril C. Adonu, Romanus C. Omeh, Blessing C. Idoko, Pamela E. Nnamani   +7 more
wiley   +1 more source

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients [PDF]

, 2021
Johannes Matthaei, Jürgen Brockmöller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Maria Kullmann, Ole Jensen, Typhaine Ouethy, Mladen V. Tzvetkov, Muhammad Rafehi   +9 more
openalex   +1 more source

Targeting the TRIM28–EZH2 Protein–Protein Interface With Cysteine‐Reactive Covalent Inhibitors: A Computational Blueprint for Cancer Therapy

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Graphical overview of the computational strategy employed to disrupt the oncogenic TRIM28EZH2 proteinprotein interaction. The workflow illustrates proteinprotein docking to define the interaction interface, cysteine‐focused covalent virtual screening targeting EZH2 Cys144, covalent docking, molecular dynamics simulations, and MM‐GBSA binding free ...
Ibrahim Oluwatobi Kehinde, Vuyisa Mzozoyana, Sizwe J. Zamisa, Mbuso Faya, Mahmoud E. S. Soliman   +4 more
wiley   +1 more source

9‐Deoxymuzigadial, a Sesquiterpene Isolated From Drimys brasiliensis (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The aims of this study were to investigate in vitro cytotoxic potential and the effects of daily administration during the inflammatory response induced by sponge implants in mice of the sesquiterpene 9‐deoxymuzigadial (9‐DOM), isolated from Drimys brasiliensis (Winteraceae).
Bruno Antonio Ferreira, Isabella Silva Cassimiro, Francyelle Borges Rosa de Moura, Tais de Campos Lima, Danielle Reis Napolitano, Eric Umehara, João Henrique Ghilardi Lago, Fernanda de Assis Araújo   +7 more
wiley   +1 more source

CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification [PDF]

, 2015
Andrea Gaedigk, Amanda K. Riffel, J. Steven Leeder   +2 more
openalex   +1 more source

Donepezil‐Induced Severe Anorexia and T‐Wave Inversion in Early‐Onset Alzheimer's Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Donepezil hydrochloride, used to treat Alzheimer's disease, is typically initiated at a low dose and titrated to minimize gastrointestinal side effects. Despite its favorable safety profile, the patient developed severe anorexia, dehydration, and electrocardiographic abnormalities.
Nobuyuki Takahashi, Takeshi Kuroda, Takashi Yoshioka, Hidetomo Murakami, Hironori Tanaka   +4 more
wiley   +1 more source

CYP2D6 Genetic Variation and Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis [PDF]

, 2022
Yanisa Wannasuphoprasit, Stig Ejdrup Andersen, María J. Arranz, Rosa Catalán, Gesche Jürgens, Sanne Kloosterboer, Henrik Berg Rasmussen, Anjali Bhat, Haritz Irizar, Dóra Koller, Renato Polimanti, Baihan Wang, Eirini Zartaloudi, Isabelle Austin-Zimmerman, Elvira Bramon   +14 more
openalex   +1 more source

A Human Mass Balance and Metabolism Study of [14C]‐Ubrogepant in Healthy Male Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Ubrogepant is a calcitonin gene–related peptide receptor antagonist approved for the acute treatment of migraine with or without aura in adults. The mass balance and metabolism of ubrogepant was evaluated in six healthy male adults administered a single oral dose of [14C]‐ubrogepant 50 mg (∼200 µCi).
Ramesh R. Boinpally, Joshua Rowe, Pushpa Chandrasekar, Rebecca B. White, Eugene E. Marcantonio, Nicole Trainor, Yuexia Liang, Cheri Maciolek, James H. Small, Robert Houle, Michael J. Hafey, Huizhi Xie, Jocelyn Yabut, Christine Fandozzi   +13 more
wiley   +1 more source

FROM THE EDITOR

Фармакокинетика и Фармакодинамика, 2014
В настоящем номере представлен ряд актуальных обзоров, посвящённых изучению новых лекарственных средств и межлекарственному взаимодействию. Прежде всего, продолжается серия обзоров, связанных с исследованием функционирования и полиморфизма известных ...

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