Results 141 to 150 of about 47,525 (299)

Personalized care of paediatric drug‐resistant epilepsy in Africa: A single‐centre pilot study utilizing mobile health and genetic testing

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To evaluate personalized care or precision medicine initiatives, including mobile health (mHealth) technology and genetic screening, in a South African paediatric epilepsy clinic. Method This exploratory prospective observational pilot study included 39 children aged 4 years or older with drug‐resistant epilepsy (ongoing seizures despite ...
Ian S. Olivier, Karen Fieggen, Sandra Komarzynski, Elin H. Davies, Irene Muchada, Caitlin McIntosh, Alina Esterhuizen, Richard J. Burman, Jo M. Wilmshurst, And the University of Cape Town (UCT) Human Genetics Precision Medicine Epilepsy Group, Nicholas Loxton, Shrinav R Dawlatt, Akshay Vanmali   +12 more
wiley   +1 more source

Phenotypic Activities of CYP2D6 and N-Acetyltransferase in Hyperthyroidism [PDF]

, 1997
Jae Joon Koh, Bo Yeon Cho, Kyunghoon Lee, In‐Jin Jang, Sang-Goo Shin   +4 more
openalex   +1 more source

Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen, Junkai Xiong, Xunmi Ma, Heng Wang, Panyu Cheng, Xinyu Chen, Ge Shuai, Yi Chen, Xinyue Zhang, Chen Sun, Chunhui Li, Rui Shi   +11 more
wiley   +1 more source

Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O‐demethylation in different CYP2D6 genotypes [PDF]

, 2000
Takeshi Kubota, Yoshiyuki Yamaura, Natsuki Ohkawa, Hisanori Hara, Kazuhiro Chiba   +4 more
openalex   +1 more source

Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People

Journal of the American Geriatrics Society, EarlyView.
This graphical abstract illustrates the annual prevalence of exposure to CPIC Level A drugs among older adults, categorized by type of pharmacogenetic recommendation. Data are presented per 1000 older individuals (A) and per 1000 prescriptions (B).
Zinan Zhao, Yuxuan Zhao, Xiaowen Hu, Xue Wang, Gengchen Wang, Xinyi Zhang, Wenliang Dong, Luwen Shi, Xiaodong Guan, Christine Y. Lu, Pengfei Jin, Xiaoyan Nie   +11 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, double‐blind, randomized, active‐controlled noninferiority trial with a 1:1 randomization between clonidine ...
Maddlie Bardol, Yucheng Sheng, Manuel Baarslag, Adriana Ceci, Frank Dörje, Mari‐Liis Ilmoja, Peter Larsson, Per‐Arne Lönnqvist, Tuuli Methsvat, Pavla Pokorna, Wolfgang Rascher, Joost van Rosmalen, Michael Schroth, Alessandra Simonetti, Dick Tibboel, Irmgard Toni, Catherine Tuleu, Thomas M. K. Völkl, Brian J. Anderson, Stefan Wimmer, Joseph F. Standing, Antje Neubert, CloSed Consortium   +22 more
wiley   +1 more source

Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia [version 3; peer review: 2 approved]

F1000Research
Background Cytochrome P450 2D6 (CYP2D6) is an important enzyme that metabolizes commonly used drugs, such as tramadol hydrochloride. Genetic polymorphisms of CYP2D6 have been shown to influence the pharmacodynamic properties of administered drugs.
Nuruliawaty Utami, Bagus Dermawan, Asrul Muhammad Fuad, Aufa Rizqia Haz, Rinal Effendi, . Desriani   +5 more
doaj   +1 more source

CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system [PDF]

, 2000
Gary A. Ford, Susan M. Wood, Ann K. Daly
openalex   +1 more source

Multidimensional Evaluation of Lisdexamfetamine: Pharmacology, Therapeutic Use, Toxicity and Forensic Implications

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
Structure of lisdexamfetamine dimesylate, its active metabolite d‐amphetamine and the essential amino acid l‐lysine, along with the mechanism of action and primary pharmacological and adverse effects associated with lisdexamfetamine dimesylate. TAAR1, trace amine‐associated receptor; VMAT, vesicular monoamine transporter; DAT, dopamine transporter; NAT,
Mariana Silva‐Carvalho, Daniel José Barbosa, Diana Dias da Silva, Ricardo Jorge Dinis‐Oliveira   +3 more
wiley   +1 more source

Variantes alélicas de CYP2D6: *4, *6 y *10 en una muestra de residentes del estado Aragua, Venezuela

Revista Peruana de Medicina Experimental y Salud Pública
El objetivo del estudio fue determinar la frecuencia de las variantes del gen CYP2D6: *4, *6 y *10 y predecir el fenotipo metabolizador en una muestra de 145 individuos no consanguíneos, aparentemente sanos, residentes del estado Aragua, Venezuela.
Carlos Flores-Angulo, Cecilia Villegas, Yuselin Mora, José Antonio Martínez, Teresa Oropeza, Nancy Moreno   +5 more
doaj   +2 more sources