Results 151 to 160 of about 49,005 (303)

Polymorphic drug metabolising enzymes:Assessment of activities by phenotyping and genotyping in clinical pharmacology [PDF]

, 2001
Drug effects (pharmacodynamics) are determined by drug concentration at target site and the affinity of the drug for a target. Pharmacogenetics describes inherited differences in drug metabolising enzyme activities and differences in drug transporters ...
Tamminga, Willem Jan
core   +2 more sources

Life-Threatening Serotonin Syndrome in a Patient With Chronic Heart Failure and CYP2D6*1/*5 [PDF]

, 2004
Akinori Sato, Yuji Okura, Shiroh Minagawa, Yukiko Ohno, Satoru Fujita, Daisuke Kondo, Manabu Hayashi, Satoru Komura, Kiminori Kato, Haruo Hanawa, Makoto Kodama, Yoshifusa Aizawa   +11 more
openalex   +1 more source

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 89-100, January 2026.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers

Фармакокинетика и Фармакодинамика, 2014
Peculiarities of functioning and polymorphism of cytochrome P450 isoenzyme CYP2D6. Existing methods for determining its activity using endogenous markers.
A. D. Abdrashitov, G. N. Gildeeva, G. V. Ramenskaya, V. V. Smirnov   +3 more
doaj  

Scatter plot showing the mean allelic ratios for samples with 2, 3, and 4 <i>CYP2D6</i> gene copy numbers.

, 2015
Langaee Taimour, Hamadeh Issam, B. Chapman Arlene, George John, A. Johnson Julie   +4 more
openalex   +2 more sources

Faculty Opinions recommendation of Clinical epidemiology and pharmacology of CYP2D6 inhibition related to breast cancer outcomes.

, 2011
Magnus Ingelman‐Sundberg
openalex   +2 more sources

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ASSAY OF SUBSTRATES-MARKERS OF MAIN CYTOCHROME P450 ISOFORMS AND THEIR METABOLITES USING HPLC-MS/MS

Разработка и регистрация лекарственных средств, 2019
Simultaneous quantification method of assaying main CYP isoforms substrates-markers and their metabolites in urine using HPLC-MS/MS was developed to determine activity of following isoforms: caffeine/paraxanthine for CYP1A2, losartane/E-3174 for CYP2C9 ...
E. A. Egorenkov, V. V. Smirnov
doaj  

CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tumors [PDF]

, 2005
Several polymorphisms of drug-metabolizing enzymes have been implicated in the susceptibility to tumor development. The role of the CYP2D6, GSTM1 and GSTT1 genes has been extensively studied, with alleles conferring different metabolic efficiencies and ...
Carvalheiro, M, Gomes, L, Lemos, MC, Paiva, I, Regateiro, FJ, Ribeiro, C   +5 more
core  

Artificial Intelligence‐Based In Silico Evaluation of the Pharmacological Potential and In Vitro Anti‐Malignancy Effect in the Human Glioblastoma Cell Line of the Hydrate of the Coumarin Compound Meranzin Originating From the Edible Macroalga (Bangia fuscopurpurea)

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
In U87 cells, meranzin hydrate showed cytotoxicity (MIC = 50 μM) and anti‐invasion activity (IC50 = 33.12 μM) but had no inhibitory effect on colony formation. It also suppressed the cancer stem cell property of sphere formation (IC50 = 21.43 μM). In silico analysis indicated that meranzin hydrate may downregulate the protein expression of ALDH1A1 and ...
Shi‐Ying Huang, Yi‐Chen Chang, Charles Chien‐Chih Chiu, Chang‐Wei Hsieh, Chien‐Wei Feng, Zhi‐Cheng Chen, Nan‐Fu Chen, Yung‐Kuo Lee, Tian‐Huei Chu, Cheng‐Chieh Fang, Nan‐Chieh Huang   +10 more
wiley   +1 more source