Results 181 to 190 of about 49,005 (303)

Phenanthrene Alkaloids From Guatteria Olivacea as Topoisomerase II Inhibitors: Theoretical Insights and Cytotoxic Evaluation

ChemistrySelect, Volume 11, Issue 2, 15 January 2026.
Three phenanthrene alkaloids from Guatteria olivacea were studied by DFT, docking, MD, and cytotoxicity assays. All compounds showed stable binding to DNA–topoisomerase II and human serum albumin. Atherosperminine exhibited cytotoxic activity against four cancer cell lines, supporting its potential as a topoisomerase II inhibitor and anticancer ...
Renyer A. Costa, Victor L. Tananta, Ianni de O. Corrêa, Jamelah S. Al‐Otaibi, Y. Sheena Mary, Milena Botelho P. Soares, Daniel P. Bezzera, Morgana de S. Araújo, Emmanoel V. Costa   +8 more
wiley   +1 more source

CYP2D6*17 Allele [PDF]

, 2020
openaire   +1 more source

Characterization of complex structural variation in the CYP2D6-CYP2D7-CYP2D8 gene loci using single-molecule long-read sequencing [PDF]

, 2023
Amy Turner, Ashley D. Derezinski, Andrea Gaedigk, Mark E. Berres, David Gregornik, Keith Brown, Ulrich Broeckel, Gunter Scharer   +7 more
openalex   +1 more source

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source

Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity. [PDF]

PLoS One
Obara C, Iizaka Y, Mine A, Anzai Y, Tada M, Yamaguchi S.   +5 more
europepmc   +1 more source

Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score

, 2012
Alan H.B. Wu, Wendy Lorizio, Simone Tchu, Kara L. Lynch, Roy Gerona, Wuyang Ji, Weiming Ruan, Kathryn J. Ruddy, Stephen DeSantis, Harold J. Burstein, Elad Ziv   +10 more
openalex   +1 more source

Rolapitant Is a Reversible Inhibitor of CYP2D6 [PDF]

, 2019
Sarah M. Glass, Sabrina M. Leddy, Michael Orwin, Garret P. Miller, Kyle A. Furge, Laura Lowe Furge   +5 more
openalex   +1 more source

Hyperfiltration and Metabolism Before and After a Low‐Calorie, Pre‐Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Psychotropic drug concentrations increase/decrease with hydrophilicity/lipophilicity after a low‐calorie pre‐bariatric surgery diet. To investigate underlying mechanisms, body weight and serum creatinine/cystatin C changes over the diet period were characterized and suggested to reflect changes in glomerular filtration and metabolic capacity ...
Magnus A. B. Axelsson, Susanna M. Wallerstedt   +1 more
wiley   +1 more source

CYP2D6*40 Allele [PDF]

, 2020
openaire   +1 more source

CYP2D6*12 Allele [PDF]

, 2020
openaire   +1 more source