Results 181 to 190 of about 47,525 (299)

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6

, 2000
Jae Wook Ko, Zeruesenay Desta, Nadia Soukhova, Timothy S. Tracy, David A. Flockhart   +4 more
openalex   +1 more source

The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine [PDF]

, 2002
Sally Usdin Yasuda, Peter Zannikos, Andrea E. Young, Karen Fried, Irving W. Wainer, Raymond L. Woosley   +5 more
openalex   +1 more source

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1598-1615, October 2025.
ABSTRACT Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations.
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
wiley   +1 more source

Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs [PDF]

, 2002
Leif Bertilsson, Marja­‐Liisa Dahl, Per Dalén, Ayman Al‐Shurbaji   +3 more
openalex   +1 more source

CYP2D6 deficiency, a factor in ecstasy related deaths? [PDF]

, 2002
Tara Gilhooly, Ann K. Daly
openalex   +1 more source

Real‐World Characterization of Psychiatric Pharmacogenomic Test Ordering and Clinical Relevance in Adults and Children

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Pharmacogenomic (PGx) testing is increasingly utilized to guide psychiatric medication selection and dosing, yet real‐world characterizations of test ordering and clinical implications remain understudied. Additionally, the extent to which psychiatry‐focused PGx results inform prescribing beyond mental health medications is unclear. This study
Lusi Zhang, Anthony J. Tholkes, Kaliya C. Jones, Laylia J. Yang, Gretchen K. Sieger, Kathryn R. Cullen, Meredith L. Gunlicks‐Stoessel, Pawel Mroz, Joel F. Farley, Steven G. Johnson, Jeffrey R. Bishop   +10 more
wiley   +1 more source

The Study on CYP2D6*10 In Vivo and In Vitro.

, 2000
Tsuyoshi Fukuda, Junichi Azuma
openalex   +2 more sources

High-throughput analysis of informative CYP2D6 compound haplotypes [PDF]

, 2003
Benjamin Fletcher, David B. Goldstein, Amanda L.R Bradman, Michael E. Weale, Neil Bradman, Mark Thomas   +5 more
openalex   +1 more source

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova, Yu‐Li Chen, Anna Hostalkova, Jakub Chlebek, Chung‐Fan Hsieh, Bing‐Hung Chen, Lucie Cahlikova, Stefan Kosturko, Anders Backlund, Jim‐Tong Horng, Tsong‐Long Hwang, Michal Korinek   +11 more
wiley   +1 more source

A Complete Picture of the <i>CYP2D6</i> Heterogeneity in Northeastern Italian Genetic Isolates. [PDF]

Int J Mol Sci
Tesolin P, Nardone GG, Santin A, Pecori A, Ruberto R, Concas MP, Zampieri S, Girotto G.   +7 more
europepmc   +1 more source