Results 31 to 40 of about 49,282 (280)

CYP2D6 gene polymorphism effect on central hemodynamic parameters in patients with portal hypertension taking propranolol

Медицинский совет, 2022
Introduction. Despite the huge number of modern recommendations for the treatment of patients with liver cirrhosis, there is still no clear scheme for prescribing non-selective beta-blockers.Aim. To evaluate effect of polymorphic markers CYP2D6*3, CYP2D6*
A. I. Parusov, I. D. Loranskaya, K. A. Akmalova, Zh. A. Sozaeva, O. L. Turkina, M. S. Zastrozhin, D. A. Sychev   +6 more
doaj   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System—Results From the ADRED Study

Frontiers in Pharmacology, 2021
Cytochrome P450 (CYP) 2D6 is a polymorphic enzyme expressed in the central nervous system (CNS), important in drug metabolism and with a potentially constitutive role in CNS function such as vigilance.
Katja S. Just, Harald Dormann, Mathias Freitag, Marlen Schurig, Miriam Böhme, Michael Steffens, Catharina Scholl, Thomas Seufferlein, Ingo Graeff, Matthias Schwab, Matthias Schwab, Matthias Schwab, Julia C. Stingl   +12 more
doaj   +1 more source

The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncomplicated Acute Calculous Cholecystitis Who Underwent Cholecystectomy

Неотложная медицинская помощь, 2020
Relevance. One of the key components of the accelerated recovery protocols (ARP), in addition to minimizing the surgical approach, is an adequate postoperative analgesia.
A. A. Muradyan, D. A. Blagovestnov, D. A. Sychev, P. A. Yartsev, M. L. Rogal, L. N. Kerimova, V. T. Koroshvili, I. A. Yepifanova   +7 more
doaj   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

CYP2D6 Gene Polymorphisms and Variable Metabolic Activity in Schizophrenia Patients of Han and Tibetan Populations

Neuropsychiatric Disease and Treatment, 2022
Yong-Hang Li,1,* Wei Huang,1,* Man-Yu Xiao,2 Shi-Qing Huang,1 Hui Chen,1 Zai-Fang Li,1 Xue-Song Li,1 Yong Cheng1,2 1The Third People’s Hospital of Foshan, Foshan, Guangdong, People’s Republic of China; 2Center on Translational Neuroscience ...
Li YH, Huang W, Xiao MY, Huang SQ, Chen H, Li ZF, Li XS, Cheng Y   +7 more
doaj  

Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays [PDF]

, 2010
Copy number variations (CNVs) in the CYP2D6 gene contribute to interindividual variation in drug metabolism. As the most common duplicated allele in Asian populations is the nonfunctional CYP2D6*36 allele, the goal of this study was to identify CNV ...
Flockhart, David A., Hosono, Naoya, Kubo, Michiaki, Nakamura, Yusuke, Ramamoorthy, Anuradha, Skaar, Todd C.   +5 more
core   +1 more source

Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]

, 2011
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core   +1 more source

CYP2D6 gene polymorphic markers role in determining the optimal treatment tactics for portal hypertension in patients with liver cirrhosis

Терапевтический архив, 2022
Aim. To study the polymorphic markers CYP2D6*4 (G1846A, rs3892097), CYP2D6*6 (T1707del, rs5030655), CYP2D6*10 (C100T, rs1065852), CYP2D6*41 (G2988A, rs28371725) and CYP2D6*3 (A2549del, rs4986774) role in treatment optimization of portal hypertension with
Dmitry A. Sychev, Andrei I. Parusov, Irina D. Loranskaya, Natalia P. Denisenko, Kristina A. Akmalova, Zhannet A. Sozaeva, Olga L. Turkina, Michael S. Zastrozhin   +7 more
doaj   +1 more source

CYP2D6 genetic polymorphisms and phenotypes in different ethnicities of Malaysian breast cancer patients [PDF]

, 2016
The cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) is an enzyme that is predominantly involved in the metabolism of tamoxifen. Genetic polymorphisms of the CYP2D6 gene may contribute to inter-individual variability in tamoxifen metabolism,
, Sharifah Noor Akmal, Abdul Rahman, Sabariah, Fee, Wai Chin, Rosli, Rozita, Soon, Choy Chan   +4 more
core   +1 more source