Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants
Frontiers in Pharmacology, 2010 Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and
Andrea Gaedigk +6 more
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Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis. [PDF]
PLoS ONE, 2011 CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20-25% of clinically used drugs including antidepressants.
Rula Y Qumsieh +5 more
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Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain [PDF]
, 2012 The development of clinica lpractice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in
Abad Santos, Francisco +18 more
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A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication. [PDF]
PLoS ONE, 2015 BACKGROUND:Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients.
Taimour Langaee +4 more
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CYP2D6 genotyping in the daily routine of a psychiatric hospital – pharmacoeconomic evaluation
Фармакоэкономика, 2018 Today, pharmacogenetic tests are commonly used to improve the efficacy and safety of antipsychotic (AP) treatment. However, the economic aspects of their implementation in the psychiatry clinic routine are not well studied.Aim.To evaluate the ...
A. A. Kurylev +3 more
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No association of a set of candidate genes on haloperidol side effects. [PDF]
, 2012 We previously investigated a sample of patients during an active phase of psychosis in the search for genetic predictors of haloperidol induced side effects.
De Ronchi, Diana +8 more
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Sex Differences in Associations Between CYP2D6 Phenotypes and Response to Opioid Analgesics
Pharmacogenomics and Personalized Medicine, 2020 Guilherme S Lopes,1,2 Suzette J Bielinski,2 Ann M Moyer,3 John Logan Black III,3 Debra J Jacobson,1 Ruoxiang Jiang,1 Nicholas B Larson,1 Jennifer L St Sauver2 1Division of Biomedical Statistics and Informatics, Department of Health Sciences Research ...
Lopes GS +7 more
doaj
Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes
Pharmaceutical Biology, 2020 Context Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine.
Mingwei Wang +4 more
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Current medical treatment of estrogen receptor-positive breast cancer [PDF]
, 2015 Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients.
Basso, S. M. M. +2 more
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Metoclopramide Neurological Side Effects Screening; A Pharmacovigilence Study in Romanian Community Pharmacies [PDF]
, 2015 Background. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics.
Junghină, Adrian +4 more
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