Results 31 to 40 of about 49,005 (303)

Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis. [PDF]

PLoS ONE, 2011
CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20-25% of clinically used drugs including antidepressants.
Rula Y Qumsieh, Bassam R Ali, Yousef M Abdulrazzaq, Ossama Osman, Nadia A Akawi, Salim M A Bastaki   +5 more
doaj   +1 more source

Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants

Frontiers in Pharmacology, 2010
Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and
Andrea Gaedigk, Lazara K M Jaime, Joseph S Bertino, Jr, Anick Bérard, Victoria Pratt, L D Bradford, J S Leeder   +6 more
doaj   +1 more source

A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication. [PDF]

PLoS ONE, 2015
BACKGROUND:Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients.
Taimour Langaee, Issam Hamadeh, Arlene B Chapman, John G Gums, Julie A Johnson   +4 more
doaj   +1 more source

Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial [PDF]

, 2012
Licensed under a Creative Commons Attribution Non-Commercial Share Alike ...
A Howell, B Bonanni, H Brauch, HS Lim, I Sestak, I Sestak, J Cuzick, J Cuzick, J Cuzick, J Cuzick, J F Forbes, J Tyrer, JE Mortimer, JM Rae, K Kiyotani, L Azoulay, M Fontecha, M Nikoloff, MJ Higgins, MM Regan, MP Goetz, MP Goetz, NL Henry, P Wegman, R Kealy, S Borges, SA Nowell, U Veronesi, U Veronesi, W Schroth, Y Xu, Z Desta   +31 more
core   +1 more source

Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain [PDF]

, 2012
The development of clinica lpractice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in
Abad Santos, Francisco, Aldea, Ana, Alonso-Navarro, Hortensia, Bernal, María Luisa, Borobia, Alberto M., Borràs, Emma, Carballo, Miguel, Carvajal, Alfonso, García-Agúndez, José Augusto, García-Martín, Elena, García-Muñiz, José D., Gervasini, Guillermo, Jiménez-Jiménez, Félix Javier, Lucena, María Isabel, Martínez, Carmen, Sacristán, José A., Salado, Inés, Sinués, Blanca, Vicente, Jorge   +18 more
core   +4 more sources

Sex Differences in Associations Between CYP2D6 Phenotypes and Response to Opioid Analgesics

Pharmacogenomics and Personalized Medicine, 2020
Guilherme S Lopes,1,2 Suzette J Bielinski,2 Ann M Moyer,3 John Logan Black III,3 Debra J Jacobson,1 Ruoxiang Jiang,1 Nicholas B Larson,1 Jennifer L St Sauver2 1Division of Biomedical Statistics and Informatics, Department of Health Sciences Research ...
Lopes GS, Bielinski SJ, Moyer AM, Black III JL, Jacobson DJ, Jiang R, Larson NB, St Sauver JL   +7 more
doaj  

CYP2D6 genotyping in the daily routine of a psychiatric hospital – pharmacoeconomic evaluation

Фармакоэкономика, 2018
Today, pharmacogenetic tests are commonly used to improve the efficacy and safety of antipsychotic (AP) treatment. However, the economic aspects of their implementation in the psychiatry clinic routine are not well studied.Aim.To evaluate the ...
A. A. Kurylev, B. V. Andreev, A. S. Kolbin, O. V. Limankin   +3 more
doaj   +1 more source

CYP2D6 Substrate Dispensing Among Patients Dispensed Mirabegron: An Administrative Claims Analysis

Drugs - Real World Outcomes, 2022
Background Overactive bladder (OAB) is characterized by the presence of bothersome urinary symptoms. Pharmacologic treatment options for OAB include anticholinergics and β3-adrenergic agonists.
Mary E. Ritchey, Jingjun Wang, Jessica C. Young, Rajat Chandra, Adam Carrera, Noelia Goti, John R. Horn, Cynthia J. Girman   +7 more
doaj   +1 more source

Development and Validation of a Multigene Panel for Pharmacogenomics Testing Using Next-Generation Sequencing for Routine Clinical Practice. [PDF]

Clin Transl Sci
ABSTRACT Pharmacogenomics (PGx) is a rapidly evolving field that aims to personalize medicine by identifying genetic variations that influence drug response. While next‐generation sequencing (NGS)–based applications are not yet widely adopted in clinical routine, this study aimed to validate 9 genes of the NGS‐based Ion AmpliSeq Pharmacogenomics Panel ...
Hongkaew Y, Kunadirek P, Sangtian M, Pateetin P, Bunlungsup S, Panmontha W, Kawprasertsri S, Khunlertkit T.   +7 more
europepmc   +2 more sources

Current medical treatment of estrogen receptor-positive breast cancer [PDF]

, 2015
Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients.
Basso, S. M. M., Lumachi, Franco, Santeufemia, D. A.   +2 more
core   +1 more source