Results 71 to 80 of about 49,282 (280)

CYP2D6 genotype and adjuvant tamoxifen:meta-analysis of heterogeneous study populations [PDF]

, 2014
The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated
Altman, R. B., Altman, Russ B., Ambrosone, C. B., Ambrosone, Christine A., Ambrosone, Christine B., Ames, M. M., Beckmann, M. W., Beckmann, Matthias W., Boländer, Julia, Brauch, H., Brauch, Hiltrud, Choi, J. Y., Choi, Ji Yeob, Dieudonné, A. S., Dieudonné, Anne Sophie, Eichelbaum, M., Eichelbaum, Michel, Fasching, P. A., Fasching, Peter A., Ferraldeschi, R., Ferraldeschi, Roberta, Fischer-Bosch, Margarete, Flockhart, D. A., Flockhart, David A., Fritz, Peter, Goetz, M. P., Goetz, Matthew P., Gong, L., Gong, Li, H, Elad Ziv, Hamann, U., Hamann, Ute, Haschke-Becher, E., Haschke-Becher, Elisabeth, Hebert, J. M., Hebert, Joan M., Howell, Anthony, Ingle, J. N., Ingle, James N., Jordan, L. B., Jordan, Lee B., Jordan, V. C., Kiyotani, K., Kiyotani, Kazuma, Klein, T. E., Klein, Teri E., Koelbl, Heinz, Krippl, P., Lambrechts, D., Lambrechts, Diether, Langsenlehner, U., Latif, A., Latif, Ayse, Lee, M. T M, Lorizio, W., Lorizio, Wendy, Mushiroda, T., Mushiroda, Taisei, Nakamura, Y., Neven, P., Neven, Patrick, Newman, W. G., Newman, William G., Nguyen, A. T., Nguyen, Anne T., Park, B. W., Park, Byeong Woo, Province, M. A., Province, Michael A., Purdie, C. A., Purdie, Colin A., Quinlan, P., Quinlan, Philip, Renner, W., Schmidt, M., Schmidt, Marcus, Schroth, W., Schroth, Werner, Schwab, M., Schwab, Matthias, Shin, J. G., Shin, Jae Gook, Simon, Wolfgang, Stingl, J. C., Stingl, Julia C., Strick, Reiner, Suman, V. J., Suman, Vera J., Thompson, A. M., Thompson, Alastair M., Ulmer, Hans Ulrich, Wegman, P., Wegman, Pia, Weinshilboum, R. M., Weinshilboum, Richard M., Whaley, R., Whaley, Ryan, Wingren, S., Wingren, Sten, Winter, S., Winter, Stefan, Wu, A. H B, Wu, Alan H B, Zembutsu, H., Zembutsu, Hitoshi, Zirpoli, G., Ziv, E., Ziv, Elad   +107 more
core   +3 more sources

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran [PDF]

, 2016
Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion.
Farazmandfar, T., Fazelnia, S., Hashemi-Soteh, S.M.B.   +2 more
core   +1 more source

Antidiabetic Potential of Ligands from NEIST_PMIB_06, Bacterium Associated with Hawaijar (Fermented Soy Food): Insight from in Vitro and in Silico Studies

ChemFoodChem, EarlyView.
ABSTRACT In this study, a bacterium (NEIST_PMIB_06) was isolated from Hawaijar, a fermented soy food from Manipur, Northeast India. The bacterium was inoculated and incubated to isolate bioactive compounds. Liquid‐liquid extraction was performed to obtain extracts (cell‐free and cell‐based), and their efficacy was evaluated.
A Ibeyaima, Hiranmoy Barman, Prasenjit Manna   +2 more
wiley   +1 more source

Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]

, 2016
Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core   +1 more source

Lower Dose‐Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss‐of‐Function Allele Carriers: A Longitudinal Retrospective Real‐World Study in Kidney Transplant Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non‐European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11–19%) but virtually absent in Europeans (MAF: 0.15%)
Amar D. Levens, Dirk Jan A. R. Moes, Yanick Boer, Aiko P. J. de Vries, Dorottya K. de Vries, Danny van der Helm, Soufian Meziyerh, Dave L. Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J. Swen   +10 more
wiley   +1 more source

A Review on the Potential of Application of CRISPR/Cas9 Technology in CYP3A4 and CYP2D6 Genes: A Way to Move Forward in Identifying New Drug Targets

ASM Science Journal, 2022
The cytochrome P450 (CYP) enzymes are of a ubiquitous heme–thiolate proteins family that plays an important role within the biotransformation of endogenous molecules and xenobiotics as today’s market is bio-transformed through CYP-mediated metabolism ...
Fazleen Haslinda Mohd Hatta, Ahmad Azani Othman, Rosmadi Mohd Yusoff, Siti Norsyuhada Nor Azam, Aliah Zuhairah Ali Hassan   +4 more
doaj   +1 more source

Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes [PDF]

, 2016
Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s.
Cai, Jiqun, Guo, Feng, Ma, Zhongnv, Shan, Lina, Shi, Xianbao, Zhang, Gang   +5 more
core   +5 more sources

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network

Pharmacogenomics and Personalized Medicine, 2020
Benjamin Q Duong,1 Meghan J Arwood,2 J Kevin Hicks,3 Amber L Beitelshees,4 Francesco Franchi,5 John T Houder,2 Nita A Limdi,6 Kelsey J Cook,7,8 Aniwaa Owusu Obeng,9 Natasha Petry,10 Sony Tuteja,11 Amanda R Elsey,2 Larisa H Cavallari,2 Kristin Wiisanen2 ...
Duong BQ, Arwood MJ, Hicks JK, Beitelshees AL, Franchi F, Houder JT, Limdi NA, Cook KJ, Owusu Obeng A, Petry N, Tuteja S, Elsey AR, Cavallari LH, Wiisanen K   +13 more
doaj