Results 11 to 20 of about 7,369 (184)

Cystathionine Gamma-Lyase Regulate Psilocybin Biosynthesis in Gymnopilus dilepis Mushroom via Amino Acid Metabolism Pathways [PDF]

Journal of Fungi, 2022
As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to ...
Sen Yao, Chuanzheng Wei, Hui Lin, Peng Zhang, Yuanyuan Liu, Youjin Deng, Qianhui Huang, Baogui Xie   +7 more
doaj   +2 more sources

Cystathionine gamma lyase overexpression enhances neovascularization through NAD-dependent mechanisms

, 2022
ABSTRACTObjectiveHydrogen sulfide (H2S) is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-gamma-lyase (CGL). CGL-dependant H2S production is required for neovasculariation in models of peripheral arterial disease.
Kiesworo K, MacArthur MR, Kip P, Agius T, Macabrey D, Lambelet M, Hamard L, Ozaki C, Mitchell JR, Déglise S, Mitchell SJ, Allagnat F, Longchamp A.   +12 more
europepmc   +2 more sources

NRF2 Regulates Cystathionine Gamma-Lyase Expression and Activity in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus [PDF]

Antioxidants, 2022
Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (H2S) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis.
Mohammad Jamaluddin, Aline Haas de Mello, Nisha Tapryal, Tapas K. Hazra, Roberto P. Garofalo, Antonella Casola   +5 more
doaj   +2 more sources

Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids [PDF]

Antioxidants
Cystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, but the
Francisco Arroyo Almenas, Gábor Törő, Peter Szaniszlo, Manjit Maskey, Ketan K. Thanki, Walter A. Koltun, Gregory S. Yochum, Irina V. Pinchuk, Celia Chao, Mark R. Hellmich, Katalin Módis   +10 more
doaj   +2 more sources

Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene. [PDF]

PLoS ONE, 2014
Hydrogen sulfide (H2S) is an important gaseous signaling molecule that functions in physiological and pathological conditions, such as atherosclerosis. H2S dilates vessels and therefore has been suggested as an anti-atherogenic molecule.
Sau Ha Cheung, Wai Kei Kwok, Ka Fai To, James Yun Wong Lau   +3 more
doaj   +2 more sources

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. [PDF]

Exp Eye Res, 2019
Chronic exposure of the retina to light and high concentrations of polyunsaturated fatty acid in photoreceptor cells make this tissue susceptible to oxidative damage. As retinal degenerative diseases are associated with photoreceptor degeneration, the antioxidant activity of both hydrogen sulfide (H2S) and glutathione (GSH) may play an important role ...
Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD.   +4 more
europepmc   +4 more sources

Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms. [PDF]

Antioxid Redox Signal, 2016
To investigate the regulation of hepatic glucose production by cystathionine γ-lyase (CSE)-generated hydrogen sulfide (H2S) in hepatic glucose production under physiological conditions.We found that CSE knockout (KO) mice had a reduced rate of gluconeogenesis, which was reversed by administration of NaHS (an H2S donor) (i.p.).
Untereiner AA, Wang R, Ju Y, Wu L.
europepmc   +4 more sources

Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]

PLoS ONE, 2016
Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis.
Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia   +7 more
doaj   +2 more sources

Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]

PLoS ONE, 2017
[This corrects the article DOI: 10.1371/journal.pone.0160521.].
Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia   +7 more
doaj   +2 more sources

Association of Kidney Graft Long-term Outcome With Recipient Cystathionine Gamma-lyase Polymorphisms and Hydrogen Sulfide Levels: A Cohort Study [PDF]

Transplantation Direct
Background. Hydrogen sulfide (H2S) produced endogenously by the CTH gene-encoded cystathionine gamma-lyase protects from renal ischemia–reperfusion injury in preclinical models.
Matthieu Halfon, MD, Raffaella Emsley, Thomas Agius, PhD, Arnaud Lyon, Sébastien Déglise, MD, Manuel Pascual, MD, Korkut Uygun, PhD, Heidi Yeh, MD, Leonardo V. Riella, MD, PhD, James F. Markmann, MD, PhD, Pierre-Yves Bochud, MD, Dela Golshayan, MD, PhD, Alban Longchamp, MD, PhD, the Swiss Transplant Cohort Study   +13 more
doaj   +2 more sources