Results 11 to 20 of about 11,945 (263)
Biomolecular Concepts, 2011 Cystatins are small proteins, typically composed of 100–120 amino acids, which together with similar proteins devoid of inhibitory properties, belong to a cystatin ‘superfamily’.
Esposito Veronica, Temussi Piero A.
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Cystatins in Immune System [PDF]
Journal of Cancer, 2013 Cystatins comprise a large superfamily of related proteins with diverse biological activities. They were initially characterised as inhibitors of lysosomal cysteine proteases, however, in recent years some alternative functions for cystatins have been ...
Špela Magister, Janko Kos
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Journal of Health Care for the Poor and Underserved, 2010 Cystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied and reviewed in the literature. Over the last 20 years, however, proteins containing cystatin domains but lacking protease inhibitory activities have been identified, and most likely more will be described in the near future.
Josiah, Ochieng, Gautam, Chaudhuri
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Hepatology, EarlyView., 2022 Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino +14 more
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Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes. [PDF]
PLoS ONE, 2016 Cystatin superfamily is a large group of evolutionarily related proteins involved in numerous physiological activities through their inhibitory activity towards cysteine proteases. Despite sharing the same cystatin fold, and inhibiting cysteine proteases
Suman Kumar Nandy, Alpana Seal
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How Different Snacks Produce a Distinct Effect in Salivary Protein Composition
Molecules, 2021 Saliva secretion changes in response to different stimulation. Studies performed in animals and humans suggest that dietary constituents may influence saliva composition, although the dynamics of these changes, and how they are specific for each type of ...
Carla Simões +4 more
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Microorganisms, 2023 Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MDR or
Manoj Mandal +4 more
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Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates.
PLoS ONE, 2014 Cystatins are a family of inhibitors of cysteine peptidases that comprises the salivary cystatins (D and S-type cystatins) and cystatin C. These cystatins are encoded by a multigene family (CST3, CST5, CST4, CST1 and CST2) organized in tandem in the ...
Patrícia de Sousa-Pereira +5 more
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Evolutionary Analysis of the Cystatin Family in Three Schistosoma Species
Frontiers in Genetics, 2014 The cystatin family comprises cysteine protease inhibitors distributed in 3 subfamilies (I25A-C). Family members lacking cystatin activity are currently unclassified. Little is known about the evolution of Schistosoma cystatins, their physiological roles,
Yesid eCuesta-Astroz +4 more
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Parasites & Vectors, 2015 Background Cystatins are a group of cysteine protease inhibitors responsible for physiological proteolysis regulation and present in a wide range of organisms. Studies about this class of inhibitors in parasites have contributed to clarify their roles in
Luís Fernando Parizi +8 more
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