Results 51 to 60 of about 11,945 (263)

Control of active B and L cathepsins in tissues of colorectal cancer using cystatins isolated from chicken egg proteins: <i>in vitro</i> studies

Folia Histochemica et Cytobiologica, 2012
The activity of cysteine peptidases (cathepsins B and L) was estimated in homogenates of tissues sampled during surgery from 60 patients operated due to colorectal tumors.
Julia Rudno-Rudzinska, Robert Tarnawa, Jerzy Rudnicki, Maciej Siewinski, Zygmunt Grzebieniak, Wojciech Kielan, Andrzej Hap, Anil Kumar Agrawal   +7 more
doaj   +1 more source

Cystatins and cancer

Frontiers in Bioscience, 2009
Cystatins are natural cysteine protease inhibitors which belong to a superfamily of proteins with wide occurrence in tissues. The cystatins have been shown to play multiple roles in normal and disease processes. In many different cancers the cathepsins, enzymes inhibited by cystatins, are elevated and participate in tumor growth and invasion.
openaire   +2 more sources

Cystatin 11: A New Member of the Cystatin Type 2 Family [PDF]

Endocrinology, 2002
Cystatin (CST)11, a novel member of the CST type 2 family of cysteine protease inhibitors, was identified in Macaca mulatta epididymis by subtractive hybridization cloning. The human CST11 gene on chromosome 20p11.2 is located near three other CST genes expressed predominantly in the male reproductive tract.
Katherine G, Hamil, Qiang, Liu, P, Sivashanmugam, Suresh, Yenugu, Rama, Soundararajan, Gail, Grossman, Richard T, Richardson, Yong-Lian, Zhang, Michael G, O'Rand, Peter, Petrusz, Frank S, French, Susan H, Hall   +11 more
openaire   +2 more sources

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Extent and Incidence of Pseudo‐Worsening of Kidney Function Due to Oral Antitumor Therapeutics in the AMBORA Cohort: An Analysis of Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
A considerable number of oral antitumor therapeutics (OAT) has the potential for causing pseudo‐worsening of kidney function (PW) due to inhibition of renal creatinine secretion, i.e., kidney function is unaffected, while creatinine‐based calculation of glomerular filtration rate (eGFR) erroneously indicates an impaired kidney function.
Michael I. Sponfeldner, Pauline Dürr, Phyllis Lensker, Katja Gessner, Lisa Cuba, Rainer Fietkau, Markus F. Neurath, Bernd Wullich, Marianne Pavel, Carola Berking, Matthias W. Beckmann, Andreas Mackensen, Frank Dörje, Martin F. Fromm   +13 more
wiley   +1 more source

An IQ Consortium Perspective on the FDA Guidance for Assessment of Pharmacokinetics in Participants With Impaired Renal Function

Clinical Pharmacology &Therapeutics, EarlyView.
The FDA published guidance on assessing pharmacokinetics (PK) in participants with impaired renal function in 2024. The IQ CPLG Organ Impairment Working Group summarized the industry’s perspective on this guidance by highlighting a few key updates in the 2024 guidance, including: (1) the recommendation of using estimated glomerular filtration rate ...
Yan Jin, Ashish Sharma, Mariam A. Ahmed, Sravanthi Cheeti, Ying Ou, Damayanthi Devineni, Yizhe Chen, Jitendra S. Kanodia, Yasmeen Abouelhassan, Nadia Noormohamed, Jin Zhou, Patrick Marroum, Vaishali Sahasrabudhe, Islam R. Younis   +13 more
wiley   +1 more source

Cystatin C and Uncontrolled Hypertension

The Anatolian Journal of Cardiology, 2020
Increased serum level of cystatin C, a sensitive biomarker for renal function, seems to predict adverse cardiovascular events. We investigated the predictive value of serum cystatin C for controlling hypertension in an observational study.We screened 1037 adults residing in both rural and urban communities.
Omaygenç, Mehmet Onur, Özcan, Özgür Ulaş, Çakal, Beytullah, Karaca, Oğuz   +3 more
openaire   +5 more sources

Analysis of the usefulness and benefits of ultrafiltration in cardiorenal syndrome: A systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 1194-1202, April 2025.
Abstract Aims Cardiac decompensation in cardiorenal syndrome (CRS) results in systemic congestion usually treated with diuretics. When despite high doses of diuretics, response is poor, ultrafiltration (UF) appears to be a useful and safe technique.
Borja Guerrero Cervera, Raquel López‐Vilella, Víctor Donoso Trenado, María Peris‐Fernández, Paula Carmona, Amparo Soldevila, Sergi Tormo, Ramón Devesa, María Jesús Montero Hernández, Luis Martínez Dolz, Julio Hernández Jaras, Pilar Sánchez‐Pérez, Luis Almenar‐Bonet   +12 more
wiley   +1 more source

Search for Nodulation and Nodule Development-related cystatin genes in the genome of Soybean (Glycine max)

Frontiers in Plant Science, 2016
Nodulation, nodule development and senescence directly affects nitrogen fixation efficiency, and previous studies have shown that inhibition of some cysteine proteases delay nodule senescence, so their nature inhibitors, cystatin genes, are very ...
Songli Yuan, Rong Li, Lei Wang, Haifeng Chen, Chanjuan Zhang, Limiao Chen, Qingnan Hao, Zhihui Shan, Xiaojuan Zhang, Shuilian Chen, Zhonglu Yang, Diezhen Qiu, Xinan Zhou   +12 more
doaj   +1 more source

Exploring the role of apolipoprotein ε4 in progressive myoclonic epilepsy type 1

Epileptic Disorders, EarlyView.
Abstract Objective Progressive myoclonic epilepsy type 1 (EPM1) is a neurodegenerative disease caused by biallelic variants in the cystatin B (CSTB) gene. Despite a progressive course, phenotype severity varies among patients, even within families. We studied the potential role of APOE ε4 in modifying phenotypic diversity in EPM1, given its established
Janina Gunnar, Yawu Liu, Henri Eronen, Tarja Joensuu, Marja Äikiä, Jelena Hyppönen, Katri Silvennoinen, Esa Mervaala, Juhana Hakumäki, Anna‐Elina Lehesjoki, Reetta Kälviäinen   +10 more
wiley   +1 more source