Results 121 to 130 of about 654,528 (315)
Advanced ScienceChemoselective modification of specific residues within a given protein poses a significant challenge, as the microenvironment of amino acid residues in proteins is variable.
Xiaojie Ren +18 more
doaj +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley +1 more source
Synthesis of a Novel Cysteine-Incorporated Anthraquinone Derivative and Its Structural Properties
Molecules, 2015 A novel cysteine-incorporated anthraquinone derivative was synthesized, and its molecular structure was determined by X-ray crystal analysis. Each mercapto group was located separately and did not form a disulfide bond, and hydrogen bondings and π-π ...
Akihiro Nomoto +6 more
doaj +1 more source
A Bioinspired Sensory‐CAPode With Dual Functionality: Logic Gate and Real‐Time Biosensing
Advanced Functional Materials, EarlyView.An electrochemical capacitor diode (CAPode) redefines the frontier of iontronics by seamlessly unifying logic computing and biosensing within a single biocompatible platform. Inspired by nature's own ion‐channel circuitry, this elegant ionic system transforms complex chemical signals into precise electrical responses, paving the way for next‐generation
Hanfeng Zhou +10 more
wiley +1 more source
Effect of Cadmium and/or Removal of Kernels or Shoots on the Levels of Cysteine, y-Glutamyl-cysteine, Glutathione, and TCA-soluble Thiols in Maize Seedlings [PDF]
, 1992 Six day old maize seedlings (Zea mays L.) were exposed as intact plants (A), after the removal of kernels (B) or shoots (C) or after the removal of kernels and transfer into the dark (D) to 0 or 50 micromolar cadmium for 2 days.
Brunold, Christian, Rüegsegger, Adrian
core
Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines
Advanced Functional Materials, EarlyView.Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang +13 more
wiley +1 more source
Design of Non-Cysteine-Containing Antimicrobial β-Hairpins: Structure−Activity Relationship Studies with Linear Protegrin-1 Analogues† [PDF]
, 2016 Protegrins are short, cationic peptides that display potent, broad-spectrum antimicrobial activity. PG-1, the first of the five natural analogues discovered, forms a rigid antiparallel two-stranded β-sheet that is stabilized by two disulfide bonds.
Samuel H. Gellman (621247) +3 more
core +1 more source
Chemically Fueled Systems Chemistry Across Length Scales
Advanced Functional Materials, EarlyView.Chemically fueled reaction cycles regulate processes through single and multiple catalytic sites on the molecular and assembly scale. This gives rise to unique kinetically controlled properties/functions like spatio‐temporal catalysis, oscillations, optical properties, and perform work.
Brigitte A. K. Kriebisch, Job Boekhoven
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn +7 more
wiley +1 more source