Results 201 to 210 of about 108,578 (332)

Aprotinin and its target enzymes in vitro and in vivo [PDF]

, 1990
Birnbaum, B., Fritz, Hans, Hoffmeister, H., Jochum, Marianne   +3 more
core   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Insights into the complexity of SARS-CoV-2 M^pro inhibition: Ebselen and its derivatives impair dimerisation of the enzyme. [PDF]

J Enzyme Inhib Med Chem
Fabbian S, Fabi S, Schwarz L, Preto G, Schiavinato C, Salata C, Crocetti L, Battistutta R, Gatto B, Sosic A.   +9 more
europepmc   +1 more source

Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of STXBP1‐Related Epileptic Encephalopathy

Annals of Neurology, EarlyView.
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar1, Alexey I. Nesvizhskii, Michael D. Uhler, Jack M. Parent, Yu Wang   +7 more
wiley   +1 more source

Moringa oleifera potential for the treatment and prevention of COVID-19 involving molecular interaction, antioxidant properties and kinetic mechanism. [PDF]

PLoS One
Hamadou M, Bakwo Bassogog CB, Obadias FV, Assaly AD, Mune Mune MA.   +4 more
europepmc   +1 more source

Proteinaceous Toxins in the Mucus and Proboscis of the Ribbon Worm Cephalothrix cf. simula (Palaeonemertea: Nemertea). [PDF]

Toxins (Basel)
Kuznetsov VG, Melnikova DI, Shabelnikov SV, Magarlamov TY.   +3 more
europepmc   +1 more source

Purification and structure of novel cysteine proteinase inhibitors staccopins P1 and P2, from Staphylococcus tanabeensis

, 1987
M. Saito, N. Kawaguchi, M. Hashimoto, T. Kodama, N. Higuchi, Takaharu Tanaka, K. Nomoto, T. Murachi   +7 more
semanticscholar   +1 more source

Advances of Peptides for Plant Immunity. [PDF]

Plants (Basel)
Liu M, Zhang G, Wang S, Wang Q.
europepmc   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

Angewandte Chemie International Edition, EarlyView.
Charged aryl‐ethynyl phosphonamidic and phosphonic acids are introduced as low‐reactivity electrophiles for peptide‐based activity probes that enable selective, target‐specific profiling of protein tyrosine phosphatases. The probes show no off‐target cysteine reactivity and engage only the interacting phosphatase in global proteomic analysis.
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source

Machine Learning-Guided Repositioning of a SARS-CoV-2-Targeting Molecular Series as Cruzain Inhibitors. [PDF]

ChemMedChem
Lameiro RF, Barbosa LF, Cardoso ER, Ho BS, Martins FCP, de Melo BC, Rosini F, Shamim A, Souza PM, de Souza WF, Montanari CA.   +10 more
europepmc   +1 more source