Results 151 to 160 of about 100,040 (330)

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms

Cancer Science, EarlyView.
In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
wiley   +1 more source

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core  

Regulation of cytidine aminohydrolase [PDF]

Biochemical Journal, 1969
N V, McFerran, M, Smyth, B A, Orsi
openaire   +2 more sources

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Cell, 2000
M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, T. Honjo   +5 more
semanticscholar   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Natural Variation of a PPR Coding Gene SST1 Confers Salt Tolerance During Soybean Domestication

Plant Biotechnology Journal, EarlyView.
ABSTRACT Soil salinity is one of the constraints that adversely affect seedling growth and limit soybean yield. Identifying salt tolerance genes and profiling their allele variants are crucial for elucidating the mechanisms underlying salt tolerance in soybean and enabling the genetic improvement of salt‐tolerant cultivars.
Hui Wang, Huifang Yuan, Yadi Wang, Weikang Xi, Xiaodi Wang, Ruiheng Tang, Qi Xu, Jiaying Li, Dongxu Liu, Qingyong Yang, Xutong Wang, Fanjiang Kong, Baohui Liu, Xia Li, Zhijuan Wang   +14 more
wiley   +1 more source

Artificial Mutations in the Nuclear Gene Encoding Mitochondrial RNA Polymerase Restore Pollen Fertility in Cytoplasmic Male Sterile Tomato

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cytoplasmic male sterility (CMS) and restorer of fertility (Rf) are important traits in F1 hybrid breeding. However, the CMS/Rf system has not been used in tomatoes because of the limited resources of Rf lines. In this study, we performed mutagenesis in tomato CMS seeds and successfully obtained 13 suppressor mutants with pollen fertility ...
Kosuke Kuwabara, Rika Nakajima, Van Bosstraeten Alexis Gaetan, Kentaro Ezura, Kinya Toriyama, Tohru Ariizumi, Kenta Shirasawa   +6 more
wiley   +1 more source

Acetylation of Cytidine in mRNA Promotes Translation Efficiency

Cell, 2018
Daniel Arango, David Sturgill, Najwa Alhusaini, Allissa Dillman, Thomas J. Sweet, Gavin Hanson, Masaki Hosogane, Wilson R. Sinclair, Kyster K. Nanan, Mariana D. Mandler, S. Fox, Thomas T. Zengeya, T. Andresson, J. Meier, Jeff Coller, Shalini Oberdoerffer   +15 more
semanticscholar   +1 more source