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Faculty Opinions recommendation of Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.

, 2012
Michael R. Lieber
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Cytidine Deaminases are Regulators of Estrogen Receptor Activity in Breast Cancer Cells

, 2011
Manikandan Periyasamy
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ウイルス感染とcytidine deaminase

ウイルス感染とcytidine deaminase
我々はこれまで、活性化B細胞に特異的に発現する遺伝子Activation-induced cytidine deaminase (AID)を単離し、次にAIDが抗体遺伝子の2つの遺伝子改編（クラススイッチ組換えとsomatic hypermutation）のトリガーとなる事を示してきた。すなわち、生体が抗原刺激を受けた際、B細胞が活性化されAIDを新規に発現誘導し、AIDが抗体遺伝子にDNA切断を誘導する。S領域のDNA切断はクラススイッチ組換えにつながり、AIDが可変領域に作用するとsomatic hypermutationが起こる。実際、変異によりAIDの機能不全が起こると常染色体劣性遺伝の液性免疫不全症である高IgM症候群となる事がわかっている。その後の解析より ...
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A Critical Re-Evaluation of "Activation-Induced Cytidine Deaminase: The Missing Piece of Many Puzzles" by Carvalho et al., Cell 2025;188(24):6691-6695. doi:10.1016/j.cell.2025.10.031

Wang, Ruihuang, Zhu, Qinglan, Xu, Ying, Zhou, Shu-Feng   +3 more
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Cytidine deaminase in rheumatoid arthritis

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Cytidine Deaminase in Human Lymphocytes

Nature New Biology, 1973
PERIPHERAL blood lymphocytes in culture undergo cell division in the presence of the mitogenic stimulant phyto-haemagglutinin (PHA)1. Some of the metabolic processes that occur shortly after stimulation include phosphorylation of membrane bound phosphatidyl inositol2, acetylation of histones3, changes in cyclic GMP levels4, a pronounced elevation of ...
C W, Abell, N W, Marchand
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An Overview of Cytidine Deaminases

International Journal of Hematology, 2006
Enzymes that deaminate cytidine to uridine play an important role in a variety of pathways from bacteria to man. Ancestral members of this family were able to deaminate cytidine only in a mononucleotide or nucleoside context. Recently, a family of enzymes has been discovered with the ability to deaminate cytidines on RNA or DNA.
Naveenan, Navaratnam, Rizwan, Sarwar
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Intersubunit Interactions in Human Cytidine Deaminase

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
VINCENZETTI, Silvia, COSTANZI S, CRISTALLI, Gloria, MARIANI P, QUADRINI B, CAMMERTONI N, VITA, Alberto   +6 more
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Cytidine Deaminase from Human Spleen

1989
No abstract ...
VITA, Alberto, Cacciamani, Tiziana, NATALINI, Paolo, RUGGIERI, Silverio, Magni, Giulio   +4 more
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Cytidine deaminase activity in abnormal pregnancy

International Journal of Gynecology & Obstetrics, 1993
AbstractOBJECTIVE: To determine the usefulness of cytidine deaminase (CTD) activity in the prediction of abnormal pregnancy and the prognosis of fetal outcome. METHOD: The CTD activities in 367 pregnant women and 17 placentas and their cord sera were determined.
T, Okamura, K, Kigasawa, T, Takeuchi, C, Ohta   +3 more
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