Results 181 to 190 of about 19,855,151 (220)

Nuclear Functional Divergence and Genetic Basis of Cap Colour Variation Revealed by T2T Genomes of Two Compatible Monokaryons in Pholiota adiposa

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
T2T genomes of two compatible monokaryons reveal nuclear functional specialization and identify two candidate loci on chromosomes 6 and 12 associated with red cap colour in the edible mushroom Pholiota adiposa. ABSTRACT Basidiomycete fungi maintain a dikaryotic state throughout their life cycle, in which two genetically distinct haploid nuclei coexist ...
TianYu Liu, Yangyang Fan, Yuanyuan Liu, Dong Yan, Yu Liu, Shuang Song, Caige Lu, Yuan Guo, Dianpeng Zhang, Shujing Sun, Shouxian Wang, Qi Gao   +11 more
wiley   +1 more source

Heart Donation After Controlled Circulatory Death in Noncardiac Surgery Hospitals With a Mobile Heart Team: A Case Series From an Italian Regional Program and Integrated Review of the Literature

Artificial Organs, Volume 50, Issue 11, Page 1657-1667, November 2026.
In this series of 19 DCD donors using TA‐NRP, 89.5% of hearts were successfully transplanted with no PGD, no postoperative ECMO, and no 30‐day mortality, demonstrating the feasibility and safety of this approach. ABSTRACT Controlled donation after circulatory death (cDCD) with thoracoabdominal normothermic regional perfusion (TA‐NRP) has emerged ...
Maria Benedetto, Valentina Roncarati, Arianna Campana, Erika Cordella, Domenico Nocera, Sofia Martin‐Suarez, Luca Botta, Davide Pacini, Letizia Perinati, Massimo Baiocchi, Tommaso Tonetti, Fabrizio Monaco   +11 more
wiley   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, Volume 117, Issue 11, Page 2924-2937, November 2026.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Liquid Compared to Solid Oral Formulations of the Thyroid Hormone Receptor Agonist Elunetirom Under Fasted and Fed Conditions in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Elunetirom (ABX‐002) is a brain‐targeted, oral prodrug being developed for the adjunctive treatment of major depressive disorder and bipolar depression. The active moiety, LL‐340001, is a thyroid hormone receptor agonist with modest selectivity for beta over alpha thyroid hormone receptors. Upon entering the brain, the intended site of action,
Jason R. Harris, Aernout D. van Haarst, Jill Baccei, Bridgette Franey, Jason Everett, Kory George, Sabina Paglialunga, Kenneth Webster, Michelle Hillstrand, Chris Banfield, Thomas S. Scanlan, Gudarz Davar   +11 more
wiley   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, Volume 111, Issue 11, Page 5236-5249, 1 November 2026.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Francesca Rizzo, Morena Miciaccia, Maria Grazia Perrone, Antonio Scilimati, Paola Loguercio Polosa, Francesco Bruni   +5 more
wiley   +1 more source

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Abstract 3392 Cytochrome c biogenesis in Bacteroides thetaiotaomicron

Journal of Biological Chemistry
Molly Sutherland, Raymond Tsao
openaire   +1 more source

Aspects of the biogenesis of cytochrome c oxidase in human cells

openaire   +1 more source

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Biogenesis of Cytochrome c Oxidase

Mitochondrion, 2005
Cytochrome c oxidase (COX), the terminal enzyme of electron transport chains in some prokaryotes and in mitochondria, has been characterized in detail over many years. Recently, a number of new data on structural and functional aspects as well as on COX biogenesis emerged.
Oleh Khalimonchuk, Gerhard Rödel
exaly   +3 more sources