Results 191 to 200 of about 778,835 (257)
Toxicology Letters, 1982 The N- and ring-hydroxylation of 2-acetylaminofluorene (AAF) are examined with a reconstituted cytochrome P-450 enzyme system from liver microsomal fractions from both control and 3-methylcholanthrene (MC)-pretreated mice. Partial purification of cytochrome P-450 fraction is achieved by bacterial protease treatment of microsomes followed by Triton X ...
Prabhakar D. Lotlikar, Tsing-Fu Wang
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, 1980 Publisher Summary This chapter focuses on characterization of a reconstituted cytochrome P-450 enzyme system mediating tertiary amine N-oxidation. Evidence is presented for the ability of a reconstituted system containing highly purified cytochrome P-448, NADPH-cytochrome c reductase, and lipid factor to mediate N-oxidation of N,N-dimethylaniline. In
Peter Hlavica, S. Hülsmann
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Mechanisms of Ageing and Development, 1989 The effects of long-term caloric restriction on the hepatic cytochrome P-450 dependent monooxygenase system were investigated in the 22-month-old Fischer 344 rat. Caloric restriction decreased the age-related changes in hepatic testosterone metabolism, which are associated with demasculinization of the liver.
Julian E.A. Leakey +6 more
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Journal of Endocrinology, 1983 The concentration of cytochrome P-450 in microsomes prepared from the livers of mature female Wistar-derived rats was significantly lower than in mature males. This sex difference was abolished after hypophysectomy, when the concentration of the cytochrome in males and females was not significantly different from that in the intact male.
Brian Gillham +2 more
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, 1979 Stopped flow studies were undertaken to examine the kinetics of reduction of 5,6-benzoflavone-inducible P-450 LM4 by NADPH in the presence of NADPH-cytochrome P-450 reductase and phospholipid under anaerobic CO at 25 degrees C. The reaction exhibited biphasic kinetics irrespective of NADPH concentration or of the molar ratio of reductase to P-450 LM4 ...
K . P Vatsis, D . D Oprian, M. J Coon
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Digestion, 1980 Effect of pretreatment (150 mumol/kg i.p. twice daily for 5 days) wtih six barbiturates (barbital, butobarbital, pentobarbital, amobarbital, phenobarbital and thiopental) on the hepatic microsomal drug methabolizing enzyme system and biliary excretion of bromcresol green and bromsulphthalein-glutathione conjugate has been investigated in rats.
E Fischer, Zoltán Gregus, F Varga
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Reaction Kinetics and Catalysis Letters, 1977 Hydroperoxide-dependent naphthalene hydroxylation involving rat liver microsomes has been studied. The direct interaction between cytochrome p-450 and cumyl hydroperoxide (CHP) has been demonstrated. Km values with respect to both the substrate and CHP have been determined using intact and induced enzyme systems.
A. A. Akhrem +3 more
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The Cytochrome P-450 Drug Metabolizing Enzyme System
Journal of Head Trauma Rehabilitation, 2002 Bruno Wroblewski, Mel B. Glenn
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Selective damage of ethanol to cytochrome P-450 enzyme system in alcoholics
Journal of Hepatology, 1989 D. von Knebel +4 more
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