Results 41 to 50 of about 35,768 (229)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

open access: yesAdvanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu   +9 more
wiley   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang   +9 more
wiley   +1 more source

Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver

open access: yesLipids in Health and Disease
Background Micro/nanoplastics (MNPs), as emerging environmental pollutants, are widely present in environments that are essential for human survival. They exist in vast quantities and possess stable properties, making them challenging to manage.
Lijuan Chen   +9 more
doaj   +1 more source

Kinetics and Mechanism of the Reaction of Coherently Synchronized Oxidation and Dehydrogenation of Cyclohexane by Hydrogen Peroxide

open access: yesMATEC Web of Conferences, 2016
Inducing effect of hydrogen peroxide on synchronous oxidation reaction is accompanied by the occurrence of two interconnected and interacting reactions. The reaction of Н2O2 decomposition (primary) generates the leading active •OH and HO•2 free radicals ...
Aghamammadova S.   +3 more
doaj   +1 more source

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

open access: yesAdvanced Science, EarlyView.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li   +8 more
wiley   +1 more source

Carbohydrate intake attenuates post-exercise plasma levels of cytochrome P450-generated oxylipins.

open access: yesPLoS ONE, 2019
INTRODUCTION:Oxylipins are bioactive oxidation products derived from n-6 and n-3 polyunsaturated fatty acids (PUFAs) in the linoleic acid and α-linolenic desaturation pathways.
David C Nieman   +5 more
doaj   +1 more source

Graphitized Biochar Derived from Agricultural Wastes Enhances Methanogenesis via Conductivity‐Driven Direct Interspecies Electron Transfer

open access: yesAdvanced Science, EarlyView.
This work clarifies how feedstocks and their structural features promote methanogenesis, and identifies the key regulatory factors, reducing pollution to the global environment, and also helps to alleviate the energy crisis. This is the first study to systematically link feedstock lignin content, pyrolysis conditions, biochar graphitization, and DIET ...
Caiyun Yang   +18 more
wiley   +1 more source

Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy

open access: yesCell Journal, 2015
Objective: Cytochrome P450 is one of the major drug metabolizing enzyme families and its role in metabolism of cancer drugs cannot be less emphasized. The association between single nucleotide polymorphisms (SNPs) in CYP1A1 and pathogenesis of chronic
Samyuktha Lakkireddy   +5 more
doaj  

In Vivo acrylamide exposure may cause severe toxicity to mouse oocytes through its metabolite glycidamide.

open access: yesPLoS ONE, 2017
High acrylamide (ACR) content in heat-processed carbohydrate-rich foods, as well as roasted products such as coffee, almonds etc., has been found to be as a risk factor for carcinogenicity and genotoxicity by The World Health Organization.
Duru Aras   +4 more
doaj   +1 more source

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