Results 41 to 50 of about 778,835 (257)

Prognostic factor identification by screening changes in differentially expressed genes in oral squamous cell carcinoma

Oral Diseases, Volume 29, Issue 1, Page 116-127, January 2023., 2023
Abstract Objective This study was designed to identify changes in the expression of proteins occurring during the progression of oral squamous cell carcinoma (OSCC) and to validate their impact on patient prognosis. Materials and Methods The human OSCC cell line UPCI‐SCC‐040 was treated in vitro with TGF‐β1, and transcriptome analysis of differentially
Boris Schminke, Orr Shomroni, Gabriela Salinas, Felix Bremmer, Philipp Kauffmann, Henning Schliephake, Felix Oyelami, Michal A. Rahat, Phillipp Brockmeyer   +8 more
wiley   +1 more source

Optimization of collective enzyme activity via spatial localization [PDF]

J. Chem. Phys. 139, 135101 (2013), 2013
The spatial organization of enzymes often plays a crucial role in the functionality and efficiency of enzymatic pathways. To fully understand the design and operation of enzymatic pathways, it is therefore crucial to understand how the relative arrangement of enzymes affects pathway function. Here we investigate the effect of enzyme localization on the
arxiv   +1 more source

In-Tip Nanoreactors for Simultaneous Proteolysis and Enrichment of Phosphorylated Peptides. [PDF]

Anal Sci Adv
ABSTRACT Protein phosphorylation introduces negative charges on the hydroxyl groups of serine, threonine, and tyrosine residues, reducing the ionization efficiency of phosphorylated peptides. The low abundance of phosphorylated peptides often diminishes their detection using mass spectrometry. To enhance the identification of the low‐abundance peptides,
Yan L.
europepmc   +2 more sources

Clustering and optimal arrangement of enzymes in reaction-diffusion systems [PDF]

Phys. Rev. Lett. 110, 208104 (2013), 2013
Enzymes within biochemical pathways are often colocalized, yet the consequences of specific spatial enzyme arrangements remain poorly understood. We study the impact of enzyme arrangement on reaction efficiency within a reaction-diffusion model. The optimal arrangement transitions from a cluster to a distributed profile as a single parameter, which ...
arxiv   +1 more source

The role of food-drug-cytochrome P450 interactions in breast cancer [PDF]

, 2018
Cytochrome P450 enzymes use a variety of molecules as substrates in enzymatic reactions, mostly catalysing oxidation of these substrates. Some of the enzymes activate carcinogenesis, including breast cancer development.
Jenzer, Helena, Relats, Claudia, Sadeghi-Reeves, Leila, Zbären, Eveline   +3 more
core   +1 more source

Neutral genetic drift can aid functional protein evolution [PDF]

Biology Direct 2:17 (2007), 2007
BACKGROUND: Many of the mutations accumulated by naturally evolving proteins are neutral in the sense that they do not significantly alter a protein's ability to perform its primary biological function. However, new protein functions evolve when selection begins to favor other, "promiscuous" functions that are incidental to a protein's biological role.
arxiv   +1 more source

Studies on cholesterol 7α-Hydroxylase [PDF]

, 1976
Attempts were made to solubilize the enzyme cholesterol 7α-hydroxylase from native rat liver microsomes and from rat liver microsomal acetone and butanol powders.
Hattersley, Neil G.
core  

Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria [PDF]

, 1971
Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation.
Allmann D. W., Ashwell M., Beattie D. S., Beattie D. S., Brunner G., Burstone M. S., Davis K. A., Delbruck A., Fiske C. H., Folch J., Gear A. R. L., Gear A. R. L., Gear A. R. L., Gelder B. F., Gotterer G. S., Hasegawa E., Hawley E. S., Johnson A. B., Klingenberg M., Kuntzel H., Labbe R. F., Lentz P. E., Neupert W., Neupert W., Novikoff A. B., Ohnishi K., Omura T., Parsons D. F., Parsons D. F., Pette D., Pollak J. K., Pullmann M. E., Raw J., Raw J., Reith A., Schneider W. C., Schuel H., Schumacher H.-H., Sebald W., Sebald W., Seligman A. M., Sies H., Sottocasa G. L., Stoffel W., Strecker H. J., Swick R. W., Szarkowska L., Tabor C. W., Tol A., Vazquez J. J., Yonetani T.   +50 more
core   +1 more source

A toy quantum analog of enzymes [PDF]

Biosystems, 162, 157-167 (2017), 2015
We present a quantum system incorporating qualitative aspects of enzyme action in which the possibility of quantum superposition of several conformations of the enzyme-substrate complex is investigated. We present numerical results showing quantum effects that transcend the case of a statistical mixture of conformations.
arxiv   +1 more source

Enzymatic formation of protopines by a microsomal cytochrome P-450 system of Corydalis vaginans [PDF]

, 1987
A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)- -N- methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing ...
Rüffer, Martina, Zenk, Meinhart H.
core   +1 more source