Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis [PDF]
Redox Biology, 2023 Identifying novel regulators of vascular smooth muscle cell function is necessary to further understand cardiovascular diseases. We previously identified cytoglobin, a hemoglobin homolog, with myogenic and cytoprotective roles in the vasculature.
Clinton Mathai +17 more
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Cytoglobin regulates NO-dependent cilia motility and organ laterality during development [PDF]
Nature Communications, 2023 Cytoglobin is a heme protein with unresolved physiological function. Genetic deletion of zebrafish cytoglobin (cygb2) causes developmental defects in left-right cardiac determination, which in humans is associated with defects in ciliary function and low
Elizabeth R. Rochon +12 more
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Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations [PDF]
Antioxidants, 2022 Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress under hypoxic ...
John Ukeri +2 more
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Effect of the distal histidine on the peroxidatic activity of monomeric cytoglobin [v1; ref status: indexed, http://f1000r.es/4xg] [PDF]
F1000Research, 2015 The reaction of hydrogen peroxide with ferric human cytoglobin and a number of distal histidine variants were studied. The peroxidase activity of the monomeric wildtype protein with an internal disulfide bond, likely to be the form of the protein in vivo,
Penny Beckerson +2 more
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Neuronal Cytoglobin in the Auditory Brainstem of Rat and Mouse: Distribution, Cochlear Projection, and Nitric Oxide Production [PDF]
Brain Sciences, 2023 Cytoglobin (Cygb), a hemoprotein of the globin family, is expressed in the supportive tissue cells of the fibroblast lineage and in distinct neuronal cell populations. The expression pattern and regulatory parameters of fibroblasts and related cells were
Stefan Reuss +3 more
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Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature [PDF]
Redox BiologyThe oxidant hydrogen peroxide (H2O2) serves as a signaling molecule that alters many aspects of cardiovascular functions and contributes to cardiovascular diseases.
Frances Jourd’heuil +9 more
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Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions [PDF]
Brain SciencesGlobins are a class of globular proteins that function in the transportation or storage of oxygen. They are critical for cellular metabolism. Notable examples include hemoglobin, which is found in red blood cells, and myoglobin, which is present in ...
Stefan Reuss
doaj +2 more sources
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin [PDF]
Scientific Reports, 2021 Cytoglobin is important in the progression of oral squamous cell carcinoma but the molecular and cellular basis remain to be elucidated. In the current study, we develop a new cell model to study the function of cytoglobin in oral squamous carcinoma and ...
Lorna S. Thorne +6 more
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The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms [PDF]
Journal of Hematology & Oncology, 2016 Background Neuroblastoma is a relatively common and highly belligerent childhood tumor with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2-pyridylketone thiosemicarbazone series, namely di-2-pyridylketone 4,4 ...
Zhu-Ling Guo +5 more
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Role of Nrf2/HO-1 and cytoglobin signaling in the protective effect of indole-3-acetic acid and chenodeoxycholic acid against kidney injury induced by valproate [PDF]
HeliyonBackground: Purpose: Valproate (VPA) is an antiepileptic drug widely used to treat various psychiatric and neurological disorders. Although its use is generally considered safe, chronic administration may lead to kidney injury.
Ahlam M. Alhusaini +9 more
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