Results 31 to 40 of about 2,444 (195)

Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Advanced Science, Volume 10, Issue 30, October 26, 2023., 2023
This review explores nitric oxide's (NO) roles in physiology and pathology while considering its advantages and limitations. Progress in designing versatile materials as NO donors and carriers for bioavailability and function at target sites is discussed. It summarizes therapeutic potential, challenges, and prospects in biomedicine.
Syed Muntazir Andrabi, Navatha Shree Sharma, Anik Karan, S. M. Shatil Shahriar, Brent Cordon, Bing Ma, Jingwei Xie   +6 more
wiley   +1 more source

Changes of globins expression in tongue sole, Cynoglossus semilaevis (Actinopterygii: Pleuronectiformes: Cynoglossidae) in response to short-term hypoxia [PDF]

Acta Ichthyologica et Piscatoria, 2011
Background. Fishes live in the aquatic systems which are first affected by low or temporally changing O2 availability. Under hypoxia, the fish possess varieties of mechanism to ensure the uptake of an adequate amount of O2.
S. Wang Z., T. Qi Z., M. Qiu, H. Zhao W., M. Wang A., T. Huang J., J. Guo X.   +6 more
doaj   +3 more sources

Nitric Oxide Production and Regulation in the Teleost Cardiovascular System

Antioxidants, 2022
Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular ...
Daniela Giordano, Cinzia Verde, Paola Corti   +2 more
doaj   +1 more source

Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance

Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023
Programmed cell death mainly include ferroptosis (A), necroptosis (B), and pyroptosis (C), which are morphologically similar and can induce severe inflammatory responses. Notably, ferroptosis, necroptosis, and pyroptosis also participate in the occurrence and development of cancers.
Xudong Zhu, Shenglong Li
wiley   +1 more source

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. [PDF]

, 2018
Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis.
Arcidiacono, P, Blaydon, DC, Brooke, MA, Chikh, A, Delaney, PJ, Kelsell, DP, Ng, K-E, Tinker, A, Webb, CM, Zhou, H   +9 more
core   +2 more sources

Calcineurin Activates Cytoglobin Transcription in Hypoxic Myocytes [PDF]

Journal of Biological Chemistry, 2009
Cardiac hypertrophy develops in response to a variety of cardiovascular stresses and results in activation of numerous signaling cascades and proteins. In the present study, we demonstrate that cytoglobin is a stress-responsive hemoprotein in the hypoxia-induced hypertrophic myocardium and it is transcriptionally regulated by calcineurin-dependent ...
Sarvjeet, Singh, Shilpa M, Manda, Devanjan, Sikder, Michael J, Birrer, Beverly A, Rothermel, Daniel J, Garry, Pradeep P A, Mammen   +6 more
openaire   +2 more sources

Multisite and multitimepoint proteomics reveal that patent foramen ovale closure improves migraine and epilepsy by reducing right‐to‐left shunt‐induced hypoxia

MedComm, Volume 4, Issue 4, August 2023., 2023
Patent foramen ovale (PFO), a congenital heart disease causing right‐to‐left shunt, is considered as one etiological factor of neurological chronic diseases with episodic manifestations (NCDEMs). PFO closure can improve NCDEMs and relieve hypoxic state.
Bosi Dong, Ying Lu, Siyu He, Baichuan Li, Yajiao Li, Qi Lai, Wanling Li, Shuming Ji, Yucheng Chen, Lunzhi Dai, Lei Chen   +10 more
wiley   +1 more source

Neuroglobin and cytoglobin [PDF]

EMBO reports, 2002
Neuroglobin and cytoglobin are two recently discovered members of the vertebrate globin family. Both are intracellular proteins endowed with hexacoordinated heme‐Fe atoms, in their ferrous and ferric forms, and display O2 affinities comparable with that of myoglobin.
PESCE, ALESSANDRA, BOLOGNESI, MARTINO, BOCEDI A., ASCENZI P., DEWILDE S., MOENS L., HANKELN T., BURMESTER T.   +7 more
openaire   +4 more sources

Stellate cell in hepatic inflammation and acute injury

Journal of Cellular Physiology, Volume 238, Issue 6, Page 1226-1236, June 2023., 2023
Abstract The perisinusoidal hepatic stellate cells (HSCs) have been investigated extensively for their role as the major fibrogenic cells during chronic liver injury. HSCs also produce numerous cytokines, chemokines, and growth mediators, and express cell adhesion molecules constitutively and in response to stimulants such as endotoxin ...
Richa Rani, Chandrashekhar R. Gandhi
wiley   +1 more source

In vitro modeling of liver fibrosis with 3D co‐culture system using a novel human hepatic stellate cell line

Biotechnology and Bioengineering, Volume 120, Issue 5, Page 1241-1253, May 2023., 2023
Abstract Hepatic stellate cells (HSCs) play an important role in liver fibrosis; however, owing to the heterogeneity and limited supply of primary HSCs, the development of in vitro liver fibrosis models has been impeded. In this study, we established and characterized a novel human HSC line (LSC‐1), and applied it to various types of three‐dimensional (
Ho‐Joon Lee, Seon Ju Mun, Cho‐Rok Jung, Hyun‐Mi Kang, Jae‐Eun Kwon, Jae‐Sung Ryu, Hyo‐Suk Ahn, Ok‐Seon Kwon, Jiwon Ahn, Kyung‐Sik Moon, Myung Jin Son, Kyung‐Sook Chung   +11 more
wiley   +1 more source