Results 41 to 50 of about 2,444 (195)
The Role of Cytoglobin in Cancer
Jurnal Biomedika dan Kesehatan, 2023 Cytoglobin (Cygb) is a new member of the globin protein family, following the discovery of other globin proteins such as hemoglobin (Hb), myoglobin (Mb), and neuroglobin (Ngb). In 2001, Kawada et al. identified Cygb in hepatic stellate cells (HSCs) that play an important role in the repair of damaged liver cell tissue, hence the name stellate cell ...
Deasyka Yastani +2 more
openaire +1 more source
ROS production is essential for the apoptotic function of E2F1 in pheochromocytoma and neuroblastoma cell lines [PDF]
, 2012 In this study we demonstrate that accumulation of reactive oxygen species (ROS) is essential for E2F1 mediated apoptosis in ER-E2F1 PC12 pheochromocytoma, and SH-SY5Y and SK-N-JD neuroblastoma stable cell lines. In these cells, the ER-E2F1 fusion protein
Ambrosio Viale, Santiago +6 more
core +12 more sources
Pharmaceuticals, 2022 Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders.
Emad H. M. Hassanein +9 more
doaj +1 more source
Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating [PDF]
, 2019 Neuroglobin (Ngb) is predominantly expressed in neurons of the central and peripheral nervous systems and it clearly seems to be involved in neuroprotection.
Anselmi, Massimiliano +10 more
core +4 more sources
Hayati Journal of Biosciences, 2023 Hypobaric hypoxia is situation that might occur to helicopter pilots in Indonesia who must fly at an altitude of more than 3,048 m such as in Papua. It can be dangerous because hypoxic condition can affect person's performance.
Wardaya Wardaya +3 more
doaj +1 more source
Redox and Peroxidase Activities of the Hemoglobin Superfamily: Relevance to Health and Disease [PDF]
, 2016 Significance: Erythrocyte hemoglobin (Hb) and myocyte myoglobin, although primarily oxygen-carrying proteins, have the capacity to do redox chemistry. Such redox activity in the wider family of globins now appears to have important associations with the ...
Brandon J. Reeder +5 more
core +1 more source
A Systematic Approach to Identifying Protein-Ligand Binding Profiles on a Proteome Scale [PDF]
, 2008 Identification of protein-ligand interaction networks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics.
Lei Xie +3 more
core +2 more sources
Cell cycle‐dependent regulation of cytoglobin by Skp2 [PDF]
FEBS Letters, 2017 Cytoglobin (Cygb) is a cellular haemoprotein belonging to the globin family with ambiguous biological functions. Downregulation of Cygb in many cancers is indicative of its tumour‐suppressive role. This is the first report showing the cell cycle regulation of Cygb, which was found to peak at G1 and rapidly decline in S phase. Importantly, Skp2‐mediated
Rince, John +5 more
openaire +2 more sources
Cytoglobin expression in rat kidney during exposure to systemic chronic hypoxia
Acta Biochimica Indonesiana, 2020 Background: The kidneys in physiological conditions are always in a state of relative hypoxia. Cytoglobin (Cygb) is the newest globin protein found of the globin family. One of the functions of Cygb is in oxygen supply.
Ika Superti Daruningrum +4 more
doaj +1 more source
CpG island methylation phenotype (CIMP) in oral cancer: associated with a marked inflammatory response and less aggressive tumour biology. [PDF]
, 2007 Studies in several tumour sites highlight the significance of the CpG island methylation phenotype (CIMP), with distinct features of histology, biological aggression and outcome.
Bowers, Naomi L +7 more
core +1 more source