Results 71 to 80 of about 2,444 (195)

Fibulin Family Members: New Players in Liver Fibrosis and Potential Biomarkers in Chronic Liver Diseases

Hepatology Research, Volume 55, Issue 11, Page 1425-1436, November 2025.
ABSTRACT Chronic liver diseases (CLD) arising from various etiologies including viral hepatitis, excessive alcohol intake, alcoholic associated liver disease (ALD) and metabolic dysfunction‐associated steatotic liver disease (MASLD), are associated with persistent hepatic injury ultimately resulting in fibrosis.
Fidaa Bouezzedine, Célia Thomas, Nathalie Théret   +2 more
wiley   +1 more source

Hypoxia Disrupts Sex‐Specific Physiology and Gene Expression Leading to Decreased Fitness in the Estuarine Sea Anemone Nematostella vectensis

Molecular Ecology, Volume 34, Issue 9, May 2025.
ABSTRACT Coastal seawater hypoxia is increasing in temperate estuaries under global climate change, yet it is unknown how low oxygen conditions affect most estuarine species. We found that hypoxia has increased since the 1990s in an estuary hosting the sea anemone Nematostella vectensis (Jacques Cousteau National Estuarine Research Reserve, New Jersey,
Benjamin H. Glass, Angela C. Ye, Cassidy N. Hemphill, Katelyn G. Jones, Anna G. Dworetzky, Katie L. Barott   +5 more
wiley   +1 more source

Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species

Oncogenesis, 2022
Pancreatic cancer is a highly challenging malignancy with extremely poor prognosis. Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is expressed in pericytes of all organs.
Dinh Viet Hoang, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Kenjiro Kimura, Daisuke Oikawa, Yoshihiro Ikura, Ninh Quoc Dat, Truong Huu Hoang, Misako Sato-Matsubara, Minh Phuong Dong, Ngo Vinh Hanh, Sawako Uchida-Kobayashi, Fuminori Tokunaga, Shoji Kubo, Naoko Ohtani, Katsutoshi Yoshizato, Norifumi Kawada   +17 more
doaj   +1 more source

Nitrite in Organ Protection [PDF]

, 2014
In the last decade, the nitrate-nitrite-nitric oxide (NO) pathway has emerged to therapeutical importance. Modulation of endogenous nitrate and nitrite levels with the subsequent S-nitros(yl)ation of the downstream signalling cascade open the way for ...
Aamand, Bachofer, Baker, Basireddy, Benjamin, Block, Bolanos, Brown, Bryan, Bryan, Bryan, Bryan, Calvert, Calvert, Calvert, Carlstrom, Cauwels, Cauwels, Cleeter, Csonka, Csonka, Csont, Csont, Dejam, Dezfulian, Dezfulian, Duranski, Elrod, Erzurum, Faassen, Fathi, Feelisch, Feelisch, Ferdinandy, Ferdinandy, Ferdinandy, Ferdinandy, Fujiwara, Gautier, Ghosh, Giricz, Gladwin, Godber, Godecke, Gracia, Harrison, Heiss, Heiss, Hendgen-Cotta, Hendgen-Cotta, Hendgen-Cotta, Hendgen-Cotta, Heusch, Higashino, Hord, Huang, Huang, Jansson, Johnson, Jung, Jung, Jung, Kapil, Kapil, Kehmeier, Kozlov, Kupai, Lai, Lang, Larsen, Larsen, Lauer, Li, Li, Liese, Loon, Lundberg, Lundberg, Lundberg, Lundberg, Lundberg, Milsom, Miyoshi, Moncada, Murata, Nguyen, Okamoto, Onody, Pacher, Pannala, Petersen, Philipp, Pickerodt, Pluta, Rassaf, Rassaf, Rassaf, Rassaf, Rassaf, Rassaf, Rassaf, Rodriguez, Samouilov, Schatlo, Schulz, Shiva, Shiva, Shiva, Sinha, Spiegelhalder, Suschek, Suschek, Tang, Terry, Tiravanti, Tiso, Tiso, Tota, Totzeck, Totzeck, Tripatara, Vanin, Velzen, Wang, Webb, Webb, Weitzberg, Wickman, Willett, Yasmin, Zuckerbraun, Zuckerbraun, Zweier, Zweier   +133 more
core   +1 more source

Iron‐Histidine Coordination in Cytochrome b5: A Local Vibrational Mode Study

ChemPhysChem, Volume 26, Issue 7, April 1, 2025.
Distal/proximal FeN bond strength and axial NFeN angle stiffness in a series of cytochrome b5s, isolated from different species such as bacteria, animals, and human were investigated with our local vibrational mode analysis combined with QM/MM calculations.
Marek Freindorf, Kevin Fleming, Elfi Kraka   +2 more
wiley   +1 more source

The different expressed serum proteins in rhCygb treated rat model of liver fibrosis by the optimized two-dimensional gel electrophoresis.

PLoS ONE, 2017
Liver fibrosis, a common pathological process of chronic liver diseases, is the final stage of liver dysfunction that has severely deleterious impact on human health. Cytoglobin was first discovered in 2001 by proteomic analysis in rat stellate cells and
Gaotai Cai, Bohong Chen, Zhen Li, Wei Wei, Ping Wang, Wenqi Dong   +5 more
doaj   +1 more source

A gene-environment study of cytoglobin in the human and rat hippocampus. [PDF]

PLoS ONE, 2013
BACKGROUND: Cytoglobin (Cygb) was discovered a decade ago as the fourth vertebrate heme-globin. The function of Cygb is still unknown, but accumulating evidence from in vitro studies point to a putative role in scavenging of reactive oxygen species and ...
Christian Ansgar Hundahl, Betina Elfving, Heidi Kaastrup Müller, Anders Hay-Schmidt, Gregers Wegener   +4 more
doaj   +1 more source

Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular Crosstalk

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Aims Since its discovery, the patatin‐like phospholipase domain containing 3 (PNPLA3) (rs738409 C>G p.I148M) variant has been studied extensively to unravel its molecular function. Although several studies proved a causal relationship between the PNPLA3 I148M variant and MASLD development and particularly fibrosis, the pathological mechanisms ...
Maria Castanho Martins, Emmanuel Dauda Dixon, Giulia Lupo, Thierry Claudel, Michael Trauner, Krista Rombouts   +5 more
wiley   +1 more source

Hypoxia/Ischemia and the Regulation of Neuroglobin and Cytoglobin Expression [PDF]

IUBMB Life, 2004
AbstractIn analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery. The Cygb gene harbours both conserved HREs and mRNA stabilization sites, strongly suggestive of an oxygen‐dependent regulation.
Fordel, Elke, Geuens, Eva, Dewilde, Sylvia, de Coen, Wim, Moens, Luc   +4 more
openaire   +3 more sources

Molecularly Imprinted Nanoparticle‐Based Polymer (Acrylamide‐N‐Vinyl imidazole)/Nafion Film Modified Screen‐Printed Electrode System for Rapid Determination of Hemoglobin

Electroanalysis, Volume 36, Issue 12, December 2024.
Abstract In medical diagnostics, variations in hemoglobin levels can reveal a variety of prevalent health conditions. Abnormal hemoglobin is known to be connected with diseases like anemia, diabetes, hematemesis, hematuria, and hemoglobinuria. Consequently, there is a significant demand for advanced detection technologies and precise methodologies to ...
Hilal Özçelik, Esra Yaşar, Timuçin Güner, Emre Dokuzparmak, Koray Şarkaya, Sinan Akgöl   +5 more
wiley   +1 more source