How can Cytokine-induced killer cells overcome CAR-T cell limits. [PDF]
Front Immunol, 2023 The successful treatment of patients affected by B-cell malignancies with Chimeric Antigen Receptor (CAR)-T cells represented a breakthrough in the field of adoptive cell therapy (ACT).
Cappuzzello E +5 more
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Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer: A meta-analysis. [PDF]
Medicine (Baltimore), 2021 Objectives: This meta-analysis was designed to systematically evaluate whether autologous cytokine-induced killer cells (CIK) or dendritic cells and cytokine-induced killer cells (DC-CIK) immunotherapy combined with chemotherapy can improve the ...
Yuan X +11 more
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Current status of cytokine-induced killer cells and combination regimens in breast cancer. [PDF]
Front ImmunolBreast cancer remains a significant health challenge worldwide, with substantial efforts aimed at understanding its pathogenesis, biological characteristics, and clinical triggers.
Jiang Y, Qiu J, Ye N, Xu Y.
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Cytokine-induced killer cells: new insights for therapy of hematologic malignancies. [PDF]
Stem Cell Res TherBackground Cytokine-induced killer (CIK) cells are a novel subgroup of immune effectors, classified as one of the modified T cell-mediated arms for immunotherapy.
Ghanbari Sevari F +4 more
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Cytokine-induced killer cells mediated pathways in the treatment of colorectal cancer. [PDF]
Cell Commun Signal, 2022 Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors.
Fayyaz F, Yazdanpanah N, Rezaei N.
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Revving up natural killer cells and cytokine-induced killer cells against hematological malignancies [PDF]
Frontiers in Immunology, 2015 Natural killer (NK) cells belong to innate immunity and exhibit cytolytic activity against infectious pathogens and tumor cells. NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin ...
Gianfranco ePittari +4 more
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Cytokine-induced memory-like natural killer cells for cancer immunotherapy [PDF]
Stem Cell Research & Therapy, 2021 Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without needing prior antigen priming.
Mubin Tarannum, Rizwan Romee
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Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2017 Cytokine-induced killer (CIK) cells are a heterogeneous population of effector CD3+CD56+ natural killer T cells, which can be easily expanded in vitro from peripheral blood mononuclear cells.
Xingchun Gao +11 more
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NKG2D Engagement Alone Is Sufficient to Activate Cytokine-Induced Killer Cells While 2B4 Only Provides Limited Coactivation. [PDF]
Front Immunol, 2021 Cytokine-induced killer (CIK) cells are an ex vivo expanded heterogeneous cell population with an enriched NK-T phenotype (CD3+CD56+). Due to the convenient and relatively inexpensive expansion capability, together with low incidence of graft versus host
Wu X +6 more
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Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells. [PDF]
Oncoimmunology, 2020 Cytokine-Induced Killer (CIK) cells share several functional and phenotypical properties of both T and natural killer (NK) cells. They represent an attractive approach for cell-based immunotherapy, as they do not require antigen-specific priming for ...
Sommaggio R +7 more
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