Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation [PDF]
Haematologica, 2010 Background Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
Selim Kuçi +12 more
doaj +3 more sources
Current status of cytokine-induced killer cells and combination regimens in breast cancer [PDF]
Frontiers in ImmunologyBreast cancer remains a significant health challenge worldwide, with substantial efforts aimed at understanding its pathogenesis, biological characteristics, and clinical triggers.
Yuancong Jiang +3 more
doaj +2 more sources
How can Cytokine-induced killer cells overcome CAR-T cell limits [PDF]
Frontiers in Immunology, 2023 The successful treatment of patients affected by B-cell malignancies with Chimeric Antigen Receptor (CAR)-T cells represented a breakthrough in the field of adoptive cell therapy (ACT).
Elisa Cappuzzello +7 more
doaj +2 more sources
Revving up natural killer cells and cytokine-induced killer cells against hematological malignancies [PDF]
Frontiers in Immunology, 2015 Natural killer (NK) cells belong to innate immunity and exhibit cytolytic activity against infectious pathogens and tumor cells. NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin ...
Gianfranco ePittari +4 more
doaj +3 more sources
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 [PDF]
Nature Communications, 2018 Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ...
Meng Zhao +10 more
doaj +5 more sources
Combined immunotherapy with dendritic cells and cytokine-induced killer cells for solid tumors: a systematic review and meta-analysis of randomized controlled trials [PDF]
Journal of Translational MedicineBackground Immunotherapy utilizing dendritic cells (DCs) and cytokine-induced killer (CIK) cells is a promising treatment approach for solid tumors.
Wendi Jiang +11 more
doaj +2 more sources
Cytokine-induced killer cells mediated pathways in the treatment of colorectal cancer [PDF]
Cell Communication and Signaling, 2022 Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors.
Farimah Fayyaz +2 more
doaj +2 more sources
Cytokine-induced killer cells: new insights for therapy of hematologic malignancies [PDF]
Stem Cell Research & TherapyBackground Cytokine-induced killer (CIK) cells are a novel subgroup of immune effectors, classified as one of the modified T cell-mediated arms for immunotherapy.
Faezeh Ghanbari Sevari +4 more
doaj +2 more sources
One Single Site Clinical Study: To Evaluate the Safety and Efficacy of Immunotherapy With Autologous Dendritic Cells, Cytokine-Induced Killer Cells in Primary Hepatocellular Carcinoma Patients [PDF]
Frontiers in Oncology, 2020 Dendritic cells (DCs) and cytokine-induced killer (CIK) cells play an important role in the anti-tumor immune response. In this study, we evaluated the clinical effectiveness of DC/CIK-CD24 immunotherapies to primary hepatocellular carcinoma patients who
Kaiyue Xu +5 more
doaj +2 more sources
Translational Oncology, 2022 Dendritic cells (DCs) are the most potent antigen-presenting cells, and have thus been used in clinical cancer vaccines. However, the effects of DC vaccines are still limited, leading researchers to explore novel ways to make them effective.
Tan-Huy Chu +10 more
doaj +1 more source