Results 31 to 40 of about 7,183,853 (276)

Cytotoxic capacity of IL-15-stimulated cytokine-induced killer cells against human acute myeloid leukemia and rhabdomyosarcoma in humanized preclinical mouse models [PDF]

, 2012
Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high-risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas.
Wels, Winfried, Simone eFulda, Bader, Peter, Eva eRettinger, Koscielniak, Ewa, Winfried eWels, Meyer, Vida, Hermann eKreyenberg, Andreas eVolk, Selim Kuçi, Volk, Andreas, Simone Fulda, Thomas eKlingebiel, Willasch, Andre Manfred, Andreas Volk, Halvard Boenig, Klingebiel, Thomas, Kuçi, Selim, Peter Bader, Eva Rettinger, Thomas Klingebiel, Vida Meyer, Ewa eKoscielniak, Fulda, Simone, Andre eWillasch, Kreyenberg, Hermann, Halvard eBoenig, Bönig, Halvard-Björn, Rettinger, Eva, Vida eMeyer, Hermann Kreyenberg, Peter eBader, Selim eKuci, Ewa Koscielniak, Andre Willasch, Winfried S. Wels   +35 more
core   +1 more source

Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors

Haematologica, 2010
Background Cytokine-induced killer cells are ex vivo-expanded cells with potent antitumor activity. The infusion of cytokine-induced killer cells in patients with acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplant is ...
Virna Marin, Irene Pizzitola, Valentina Agostoni, Greta Maria Paola Giordano Attianese, Helene Finney, Alastair Lawson, Martin Pule, Raphael Rousseau, Andrea Biondi, Ettore Biagi   +9 more
doaj   +1 more source

Activation of human natural killer cells by Plasmodium falciparum [PDF]

, 2003
The purpose of work described in this thesis was to (i) determine the contribution of innate immune responses to the early pro-inflammatory cytokine response to Plasmodium falciparum, (ii) describe the kinetics and ...
Artavanis-Tsakonas, Katerina
core   +1 more source

Influence of Cytokines and Autologous Lymphokine-Activated Killer Cells on Leukemic Bone Marrow Cells and Colonies in AML [PDF]

, 2001
We have already shown that cytokine cocktails (IL-1 beta, IL-3, IL-6, SCF, GM-CSF) and/or lymphokine-activated killer (LAK) cells can reduce the amounts of clonal, CD34-positive mononuclear bone marrow cells (BM-MNC) in acute myeloid leukemia (AML).
Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, Susanne Walburg   +2 more
core   +1 more source

Activation of natural killer cells during microbial infections. [PDF]

, 2011
Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines.
Riley, Eleanor M, Eleanor M Riley, Amir eHorowitz, Horowitz, Amir, Stegmann, Kerstin A, Kerstin eStegmann, Amir Horowitz, Eleanor M. Riley, Kerstin A. Stegmann   +8 more
core   +1 more source

Cytokine Induced Killer (CIK) Cells Based Adoptive Immunotherapy

Journal of Gandaki Medical College, 2018
Cytokine induced killer (CIK) cells has been increasingly used in adoptive immunotherapy against various cancers and viral infections. This review summarizes the basic overview of CIK cells as a therapeutic immunocyte.
S Timalsena, P P Lamichhane
doaj   +1 more source

Cytokine-induced memory-like natural killer cells for cancer immunotherapy

Stem Cell Research & Therapy, 2021
Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without needing prior antigen priming.
Mubin Tarannum, Rizwan Romee
doaj   +1 more source

Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection [PDF]

, 2010
NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death ligand TRAIL in patients with chronic hepatitis B virus infection (CHB), allowing them to kill ...
Richard J. Gilson, Dusheiko, G., Gilson, R.J., Dunn Claire, Gilson Richard J., Peppa, D, Patrick T F Kennedy, Ellis, G., Claire Dunn, Celeste Pallant, Dunn, C., Geoffrey Dusheiko, Lorenzo Micco, Dusheiko Geoffrey, Maini Mala K., Micco, L, Ellis, G, Pooja Khanna, Maini, MK, Pallant, C., Micco Lorenzo, Khanna, P, Javaid, A., Gilson, RJ, Micco, L., Mala K Maini, Schurich, A.; id_orcid, Javaid Alia, Khanna Pooja, Schurich, A, Kennedy, P.T.F., Anna Schurich, Pallant, C, Kennedy Patrick T. F., Mala K. Maini, Khanna, P., Peppa Dimitra, Gidon Ellis, Dusheiko, G, Javaid, A, Ellis Gidon, Dimitra Peppa, Dunn, C, Patrick T. F. Kennedy, Pallant Celeste, Maini, M.K., Kennedy, PTF, Alia Javaid, Peppa, D., Schurich Anna, Richard J Gilson   +50 more
core   +1 more source

MicroRNA profiling of CD3+CD56+ cytokine-induced killer cells [PDF]

Scientific Reports, 2015
AbstractStudies have proven that IL-2 and IL-15 showed contrasting roles during CIK cells preparation. By employing microarray, we analyzed miRNA expression profiles of PBMC, CIKIL-2 and CIKIL-15. Advanced bioinformatic analyses were performed to explore the key miRNAs which may regulate cell proliferation and anti-tumor activity of CIK.
Wenju Wang, Ruhong Li, Mingyao Meng, Chuanyu Wei, Yanhua Xie, Yayong Zhang, Lihong Jiang, Ruiyi Dong, Chunhui Wang, Yiming Zhong, Fang Yang, Weiwei Tang, Xingfang Jin, Baohua Liu, Zongliu Hou   +14 more
openaire   +2 more sources

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +2 more sources