Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells [PDF]
Immune Network, 2015 Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of
Kim, Ji Sung +6 more
openaire +2 more sources
Memory NK cell features exploitable in anticancer immunotherapy [PDF]
, 2019 Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone +5 more
core +2 more sources
Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]
, 2019 Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi +3 more
core +2 more sources
Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma.
Gastroenterology, 2015 BACKGROUND & AIMS No adjuvant therapy has been shown to extend the survival of patients with hepatocellular carcinoma (HCC) receiving curative treatment.
Joon Hyeok Lee +10 more
semanticscholar +1 more source
Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. [PDF]
, 2019 Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming.
Canter, Robert J +2 more
core +2 more sources
A dynamic transcriptomic atlas of cytokine-induced killer cells. [PDF]
J Biol Chem, 2018 Several clinical immunotherapy trials with cytokine-induced killer (CIK) cells have been reported. However, molecular evidence of cell expansion, acquisition of tumor cytotoxicity, and safety of CIK cells is required before putting them to clinical use.
Meng M +17 more
europepmc +4 more sources
Stem cell research & therapeutics, 2020 Autologous cellular immunotherapy or immune enhancement therapy has demonstrated some promising benefits for prostate cancer. T cell-based immunotherapy or sipuleucel-T therapy has yielded certain beneficial responses and a slight improvement on the ...
Zhu Wang +8 more
semanticscholar +1 more source
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]
, 1994 Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM +4 more
core +1 more source
Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells [PDF]
Clinical Cancer Research, 2017 Abstract Purpose: The MHC-unrestricted activity of cytokine-induced killer (CIK) cells against chemo-surviving melanoma cancer stem cells (mCSC) was explored, as CSCs are considered responsible for chemoresistance and relapses. Experimental Design: Putative mCSCs were visualized by engineering patient-derived ...
Gammaitoni L +21 more
openaire +2 more sources
Killers at the crossroads: The use of innate immune cells in adoptive cellular therapy of cancer
Stem Cells Translational Medicine, 2020 Adoptive cell therapy (ACT) is an approach to cancer treatment that involves the use of antitumor immune cells to target residual disease in patients after completion of chemo/radiotherapy.
May Sabry, Mark W. Lowdell
doaj +1 more source