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Cytokine release syndrome [PDF]
Journal for ImmunoTherapy of Cancer, 2018 During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific T-cell engaging (BiTE) single-chain antibody ...
Alexander Shimabukuro-Vornhagen +8 more
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Cytokine release syndrome in severe COVID-19 [PDF]
Science, 2020 Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease In December 2019, a new strain of coronavirus, severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China ...
J. B. Moore, C. June
semanticscholar +3 more sources
Rituximab and Cytokine Release Syndrome [PDF]
Case Reports in Oncology, 2012 Rituximab is a biologic agent that is usually well tolerated. With its increasing use for a myriad of rheumatologic and immunologic conditions, post-marketing surveillance has revealed more side effects. Systemic inflammatory response syndrome associated
Hrishikesh S. Kulkarni +1 more
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Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy [PDF]
Nature Reviews Immunology, 2021 A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting specific signalling pathways, have been joined by cellular immunotherapies ...
E. Morris +3 more
semanticscholar +4 more sources
Cytokine release syndrome after bronchoalveolar lavage
BMC Pulmonary Medicine, 2023 Background Immunosuppressed bone marrow transplant patients with pulmonary infiltrates routinely undergo bronchoscopy with bronchoalveolar lavage (BAL) to investigate potential etiologies.
Margaret Guerriero +3 more
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Cytokine Release Syndrome: Current Perspectives
ImmunoTargets and Therapy, 2019 Hemant Murthy,1 Madiha Iqbal,1 Julio C Chavez,2 Mohamed A Kharfan-Dabaja1 1Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL, USA; 2Department of Malignant Hematology, Moffitt Cancer Center, Tampa,
Murthy H +3 more
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Journal of Pediatric Critical CareCytokine release syndrome (CRS) is a severe, potentially life-threatening immune-mediated condition characterized by excessive cytokine secretion leading to systemic inflammation and multiorgan dysfunction.
Rachit Mehta, Indira Jayakumar
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Cytokine release syndrome: grading, modeling, and new therapy [PDF]
Journal of Hematology & Oncology, 2018 Genetically modified T cells that express a chimeric antigen receptor (CAR) are opening a new frontier in cancer immunotherapy. CAR T cells currently are in clinical trials for many cancer types.
Delong Liu, Juanjuan Zhao
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Cytokine release syndrome in solid tumors. [PDF]
CancerAbstractCytokine release syndrome (CRS) is a common and potentially severe complication of cancer immunotherapy, including CAR T‐cell therapies, bispecific T‐cell engagers, and less commonly immune checkpoint inhibitors. Although extensive research has established guidelines for managing CRS in hematological malignancies, there is a growing need to ...
Synnott D +3 more
europepmc +3 more sources
The Many Faces of Cytokine Release Syndrome-Related Coagulopathy [PDF]
Clinical Hematology International, 2021 Cytokine release syndrome (CRS) has been increasingly recognized in various conditions including the coronavirus disease 2019 (COVID-19). It is not only associated with systemic inflammatory symptoms, but also hematological complications such as ...
Jiasheng Wang, John Doran
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