Results 31 to 40 of about 193,929 (276)

Rituximab induced cytokine release syndrome in an MS patient: A case report

Clinical Case Reports, 2021
Cytokine release syndrome with rituximab has been reported in certain diseases, however, it is rarely reported in MS patients treated with rituximab. The treating physician should suspect the syndrome when typical signs and symptoms appear.
Masoud Etemadifar, Mehri Salari, Mahdieh Saeri, Amirhossein Akhavan Sigari, Sara Ebrahimi Pelarti   +4 more
doaj   +1 more source

Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the Storm

Frontiers in Immunology, 2020
SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic. It causes severe acute respiratory syndrome (COVID-19), which is fatal in many cases, and is characterized by a cytokine release syndrome (CRS).
Jesus Gonzalez-Rubio, Carmen Navarro-Lopez, Elena Lopez-Najera, Ana Lopez-Najera, Lydia Jimenez-Diaz, Juan D. Navarro-Lopez, Alberto Najera   +6 more
doaj   +1 more source

High Ferritin in a Critically ill COVID-19 Patient: The Calm before Cytokine Storm [PDF]

Journal of Clinical and Diagnostic Research, 2020
Corona Virus Disease of 2019 (COVID-19) is spreading throughout the world and the United States with confirmed cases in all 50 states. Cytokine Release Syndrome (CRS), or cytokine storm, is being increasingly reported with severe cases of COVID-19 ...
Safa Saki , Mustafa Salam Mawih
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

DeltaRex-G, tumor targeted retrovector encoding a CCNG1 inhibitor, for CAR-T cell therapy induced cytokine release syndrome

Frontiers in Molecular Medicine
Cytokine release syndrome is a serious complication of chimeric antigen receptor-T cell therapy and is triggered by excessive secretion of inflammatory cytokines by chimeric T cells which could be fatal. Following an inquiry into the molecular mechanisms
Grace Haroun, Erlinda M. Gordon
doaj   +1 more source

An interesting case of life-threatening COVID-19 pneumonia

Apollo Medicine, 2020
COVID-19 pneumonia requires intensive care unit admission in approximately 5% of patients. The treatment options are all experimental. We report a case of life-threatening COVID-19 pneumonia with cytokine release syndrome who had successful outcome with ...
Sudha Kansal, Aakanksha Chawla Jain, M S Kanwar, Avdhesh Bansal, Nikhil Modi, Athar Parvez Ansari, Roseleen Kaur Bali, Viny Kantroo, Rajesh Chawla   +8 more
doaj   +1 more source

Special case of a patient in the blast phase of chronic myeloid leukemia successfully treated with tocilizumab during critical SARS-CoV-2 infection

Journal of International Medical Research, 2022
The medical care of patients with hematological malignancies who develop coronavirus disease 2019 (COVID-19) has been a major challenge during the current pandemic.
Amine Bouchlarhem, Ounci Es-saad, Leila Haddar, Oussama Lamzouri, Ghizlane Elaidouni, Hamza Mimouni, Houssam Bkiyar, Brahim Housni   +7 more
doaj   +1 more source

A systematic review on the effects of Echinacea supplementation on cytokine levels: Is there a role in COVID-19?

Metabolism Open, 2021
COVID-19 is the respiratory illness caused by the novel coronavirus, SARS-CoV-2. Cytokine storm appears to be a factor in COVID-19 mortality. Echinacea species have been used historically for immune modulation.
Monique Aucoin, Valentina Cardozo, Meagan D. McLaren, Anna Garber, Daniella Remy, Joy Baker, Adam Gratton, Mohammed Ali Kala, Sasha Monteiro, Cara Warder, Alessandra Perciballi, Kieran Cooley   +11 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Does Vitamin D Supplementation Reduce Cytokine Storm and Mortality in Geriatric Intensive Care Patients Diagnosed with COVID-19

Journal of Contemporary Medicine, 2022
Introduction: Coronavirus disease progresses from an asymptomatic stage to a fatal stage characterized by a cytokine storm. Therefore, treatment should focus on enhancing the patients’immune function and preventing cytokine release syndrome.
Yeliz Bilir, Fulya Çiyiltepe, Akın Bilir, Ayten Saracoğlu, Elif Bombacı, Kemal Tolga Saraçoğlu, Recep Demirhan   +6 more
doaj   +1 more source