Results 131 to 140 of about 101,216 (235)
Advanced Science, Volume 13, Issue 13, 3 March 2026.This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He +7 more
wiley +1 more source
The Roles of Septins in Regulating Fission Yeast Cytokinesis
Journal of FungiCytokinesis is required to separate two daughter cells at the end of mitosis, and septins play crucial roles in many aspects of cytokinesis. While septins have been intensively studied in many model organisms, including the budding yeast Saccharomyces ...
Shengnan Zheng, Biyu Zheng, Chuanhai Fu
doaj +1 more source
Emergent Homeostasis and Degeneracy From Multi‐Dimensional Attractors
BioEssays, Volume 48, Issue 3, March 2026.Biological systems maintain homeostasis—stability to perturbations. Control theory (right) describes this as designed regulatory circuits that maintain set points. We propose that homeostasis can emerge from collective dynamics that generate stable attracting manifolds (left).
Kuheli Biswas +2 more
wiley +1 more source
PLoS Genetics, 2014 The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors.
Stefano Sechi +7 more
doaj +1 more source
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
Rho Family GTPases in Fission Yeast Cytokinesis
Communicative & Integrative Biology, 2019 During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho GTPases drive this process through the positioning and assembly of the actomyosin ring, and through extracellular matrix remodeling within the furrow.
Brian Hercyk, Maitreyi Das
doaj +1 more source
CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity
Glia, Volume 74, Issue 3, March 2026.CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert +14 more
wiley +1 more source
Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound vesicles released by any cell type under both physiological and pathological conditions. They carry a wide array of bioactive molecules, including microRNAs (miRNAs), lipids, proteins and other small biomolecules, and therefore play a key role in intercellular communication by ...
Tamer Esmail +20 more
wiley +1 more source