Results 11 to 20 of about 4,251 (182)

Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor [PDF]

Cytoskeleton (Hoboken)
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
King S.
europepmc   +2 more sources

Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. [PDF]

PLoS ONE, 2009
BACKGROUND:Cytoplasmic dynein complex is a large multi-subunit microtubule (MT)-associated molecular motor involved in various cellular functions including organelle positioning, vesicle transport and cell division.
Takuya Kobayashi, Takashi Murayama
doaj   +1 more source

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

eLife, 2020
Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee, Rachael M Cox, Ophelia Papoulas, Amjad Horani, Kevin Drew, Caitlin C Devitt, Steven L Brody, Edward M Marcotte, John B Wallingford   +8 more
doaj   +1 more source

FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex.

PLoS Genetics, 2022
Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Limei Wang, Xuecheng Li, Guang Liu, Junmin Pan   +3 more
doaj   +1 more source

Cytoplasmic dynein and early endosome transport [PDF]

Cellular and Molecular Life Sciences, 2015
Microtubule-based distribution of organelles/vesicles is crucial for the function of many types of eukaryotic cells and the molecular motor cytoplasmic dynein is required for transporting a variety of cellular cargos toward the microtubule minus ends. Early endosomes represent a major cargo of dynein in filamentous fungi, and dynein regulators such as ...
Xiang, X, Qiu, R, Yao, X, Arst, HN, Pealva, MA, Zhang, J   +5 more
openaire   +4 more sources

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

eLife, 2017
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-
Jonathan B Steinman, Cristina C Santarossa, Rand M Miller, Lola S Yu, Anna S Serpinskaya, Hideki Furukawa, Sachie Morimoto, Yuta Tanaka, Mitsuyoshi Nishitani, Moriteru Asano, Ruta Zalyte, Alison E Ondrus, Alex G Johnson, Fan Ye, Maxence V Nachury, Yoshiyuki Fukase, Kazuyoshi Aso, Michael A Foley, Vladimir I Gelfand, James K Chen, Andrew P Carter, Tarun M Kapoor   +21 more
doaj   +1 more source

Spatio-temporal regulation of nuclear division by Aurora B kinase Ipl1 in Cryptococcus neoformans. [PDF]

PLoS Genetics, 2019
The nuclear division takes place in the daughter cell in the basidiomycetous budding yeast Cryptococcus neoformans. Unclustered kinetochores gradually cluster and the nucleus moves to the daughter bud as cells enter mitosis.
Neha Varshney, Subhendu Som, Saptarshi Chatterjee, Shreyas Sridhar, Dibyendu Bhattacharyya, Raja Paul, Kaustuv Sanyal   +6 more
doaj   +1 more source

Activation and Regulation of Cytoplasmic Dynein

Trends in Biochemical Sciences, 2020
Cytoplasmic dynein is an AAA+ motor that drives the transport of many intracellular cargoes towards the minus end of microtubules (MTs). Previous in vitro studies characterized isolated dynein as an exceptionally weak motor that moves slowly and diffuses on an MT. Recent studies altered this view by demonstrating that dynein remains in an autoinhibited
John T. Canty, Ahmet Yildiz
openaire   +5 more sources

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

eLife, 2018
Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi, Toshiyuki Oda, Masahide Kikkawa, Hiroyuki Takeda   +3 more
doaj   +1 more source

Regulators of the cytoplasmic dynein motor [PDF]

Nature Reviews Molecular Cell Biology, 2009
Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos. Numerous kinesins and myosins have evolved to cope with the various transport needs that have arisen during eukaryotic evolution. Surprisingly, a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse transport ...
Julia R, Kardon, Ronald D, Vale
openaire   +2 more sources