Results 21 to 30 of about 4,251 (182)
Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
eLife, 2019 Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey +3 more
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Cytoplasmic Dynein Promotes HIV-1 Uncoating [PDF]
Viruses, 2014 Retroviral capsid (CA) cores undergo uncoating during their retrograde transport (toward the nucleus), and/or after reaching the nuclear membrane. However, whether HIV-1 CA core uncoating is dependent upon its transport is not understood. There is some evidence that HIV-1 cores retrograde transport involves cytoplasmic dynein complexes translocating on
Pawlica, Paulina, Berthoux, Lionel
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CNS myelination requires cytoplasmic dynein function [PDF]
Developmental Dynamics, 2015 Background: Cytoplasmic dynein provides the main motor force for minus‐end‐directed transport of cargo on microtubules. Within the vertebrate central nervous system (CNS), proliferation, neuronal migration, and retrograde axon transport are among the cellular functions known to require dynein.
Michele L, Yang +6 more
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PLoS Genetics, 2017 Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated.
Ryosuke Yamamoto +12 more
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Mechanism and Regulation of Cytoplasmic Dynein [PDF]
Annual Review of Cell and Developmental Biology, 2015 Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth of new structural, mechanistic, and cell biological data is shedding light on how this complicated minus-end-directed, microtubule-based motor works. Cytoplasmic dynein-1 performs a wide array of functions in most eukaryotes, both in interphase, in which it ...
Michael A, Cianfrocco +3 more
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Kinesin and dynein use distinct mechanisms to bypass obstacles
eLife, 2019 Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S Ferro +4 more
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Subunit organization in cytoplasmic dynein subcomplexes [PDF]
Protein Science, 2002 AbstractBecause cytoplasmic dynein plays numerous critical roles in eukaryotic cells, determining the subunit composition and the organization and functions of the subunits within dynein are important goals. This has been difficult partly because of accessory polypeptide heterogeneity of dynein populations.
Stephen J, King +3 more
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Unbinding Force of Cytoplasmic Dynein [PDF]
Biophysical Journal, 2011 Dynein is a molecular motor that moves toward the minus-end of microtubules using the chemical energy of ATP hydrolysis. Cytoplasmic dynein play roles in positioning the Golgi complex and other organelles in cells, movement of chromosomes, and positioning the mitotic spindles during mitosis.
Kambara, Taketoshi +2 more
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Lissencephaly-1 is a context-dependent regulator of the human dynein complex
eLife, 2017 The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach +6 more
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HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.
PLoS Genetics, 2014 Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis.
Christine P Diggle +23 more
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