Results 81 to 90 of about 31,874 (246)

Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes

Journal of Extracellular Vesicles, 2018
Newts can regenerate amputated limbs and cardiac tissue, unlike mammals which lack broad regenerative capacity. Several signaling pathways involved in cell proliferation, differentiation and survival during newt tissue regeneration have been elucidated ...
Ryan C. Middleton, Russell G. Rogers, Geoffrey De Couto, Eleni Tseliou, Kristin Luther, Ronald Holewinski, Daniel Soetkamp, Jennifer E. Van Eyk, Travis J. Antes, Eduardo Marbán   +9 more
doaj   +1 more source

Efficacy and safety of the use of rebamipide in the scheme of triple eradication therapy of Helicobacter pylori infection: a prospective randomized comparative study [PDF]

Терапевтический архив, 2018
Purpose of the study. To evaluate the effectiveness and safety of the use of rebamipide as part of the triple eradication therapy (ET) scheme of Helicobacter pylori infection. Materials and methods. A prospective, randomized comparative study included 94
D N Andreev, I V Maev, D T Dicheva, A A Samsonov, E V Partzvania-Vinogradova   +4 more
doaj   +1 more source

Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress [PDF]

, 2017
Background: Sulforaphane (SFN), a phytochemical found in abundance in broccoli sprouts, potently induces a variety of antioxidant enzymes, and thereby protects cells from injury induced by various kinds of oxidative stresses.
Yanaka Akinori, 谷中 昭典
core   +2 more sources

The role of fluvoxamine in the treatment of endotoxin‐induced acute heart injury

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cardiovascular diseases are among the most common health problems worldwide. Inflammation plays a critical role in the pathogenesis of various heart diseases. Lipopolysaccharides (LPS) trigger inflammatory mechanisms, leading to an inflammatory response.
Ilter Ilhan, Halil Aşcı, Muhammet Yusuf Tepebasi, Nursel Hasseyid, Melih Arlıoğlu, Özlem Özmen   +5 more
wiley   +1 more source

ISCHEMIC SYNDROMES AND CYTOPROTECTION (TRIMETAZIDINE)

Российский кардиологический журнал, 2001
Ischemic syndromes and cytoprotection (trimetazidine).
A. A. Gorbachenkov, V. V. Hobot
doaj  

Is sunlight good for our heart? [PDF]

, 2010
Humans evolved being exposed for about half of the day to the light of the sun. Nowadays, exposure to sunlight is actively discouraged for fear of skin cancer, and contemporary lifestyles are associated with long hours spent under artificial light ...
Feelisch, Martin, Kolb-Bachofen, Victoria, Liu, Donald, Lundberg, Jon O., Revelo, Lucia P., Suschek, Christoph V., Weller, Richard B.   +6 more
core   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

(-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms

Pharmaceuticals
Background: (-)-Fenchone is a bicyclic monoterpene present in the plant species Foeniculum vulgare Mill, Thuja occidentalis L. (tuja), and Lavandula stoechas (lavender). These plants have therapeutic value in the treatment of intestinal disorders.
Maria Elaine Cristina Araruna, Edvaldo Balbino Alves Júnior, Catarina Alves de Lima Serafim, Matheus Marley Bezerra Pessoa, Michelle Liz de Souza Pessôa, Vitória Pereira Alves, Marianna Vieira Sobral, Marcelo Sobral da Silva, Adriano Francisco Alves, Maria Carolina de Paiva Sousa, Aurigena Antunes Araújo, Leônia Maria Batista   +11 more
doaj   +1 more source

Pyrazinamide may possess cardioprotective properties [PDF]

, 2019
Pyrazinamide is an anti-tubercular agent, used as a part of a three-drug regime (any three of the following: rifampicin, isoniazid, pyrazinamide, streptomycin or ethambutol) for the initial phase of treatment.
Du, Qingyou, Jovanovic, Sofija, Jovanović, Aleksandar, Sinha, Sharabh, Sukhodub, Andriy   +4 more
core   +2 more sources

Role of the UHRF1–KLHL6–CORO2B axis in obesity‐related insulin resistance

Journal of Diabetes Investigation, EarlyView.
In high‐fat diet (HFD)‐induced obese mice with insulin resistance, overexpression of UHRF1 may recruit DNMT1 to promote DNA methylation of KLHL6, leading to its downregulation. Subsequently, suppression of KLHL6 may decrease the ubiquitination of CORO2B, resulting in elevated CORO2B protein levels.
Xu Deng, Xiaoping Li, Jialuo Cai, Xinyu Chen, Zelin Xu, Yuntao Luo   +5 more
wiley   +1 more source