Results 21 to 30 of about 133,584 (204)

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy [PDF]

, 2017
The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and ...
Fremont, Daved H, Ghasemi, Reza, Hein, Sarah M, Krupnick, Alexander Sasha, Lazear, Eric, Watkins, Dan, Westwick, John   +6 more
core   +2 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Altered CD94/NKG2A and perforin expression reduce the cytotoxic activity in malignant pleural effusions [PDF]

, 2011
CD94/NKG2A is an inhibitory receptor expressed by NK cells and cytotoxic lymphocytes and, upon activation by HLA-E, downregulates the cytolytic activities of these cells thus representing a tumour immune escape mechanism.
Bellia, V., Di Sano, C., Ferraro, M., Gjomarkaj, M., Olivieri, D., Pace, E., Santagata, R., Spatafora, M., Tipa, A.   +8 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins [PDF]

, 1993
The human serine proteases granzymes A and B are expressed in cytotoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. Recombinant granzyme A and granzyme B proteins were produced in bacteria, purified and then used to raise ...
Borst, Jannie, Brakenhoff, Just P.J., Hack, C. Erik, Kamp, Angela M., Kummer, J. Alain, Radosevic, K., Radosevic, Katarina, van Katwijk, Marcel, van Leeuwen, Anne Marie, Verweij, Cornelis L.   +9 more
core   +9 more sources

The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I [PDF]

, 2006
The major histocompatibility complex (MHC) class I region in mammals contains both classical and non-classical MHC class I genes. Classical MHC class I molecules present antigenic peptides to cytotoxic T lymphocytes, whereas non-classical MHC class I ...
Anderson, Araibi, Ashrafi, Ashrafi, Ashrafi, B. Marchetti, Borrego, Cohen, Davies, Di Palma, E.H. Araibi, E.S. Dornan, Ellis, Ellis, Ellis, Frazer, G.H. Ashrafi, Geraghty, Hofmeister, M. Dobromylskyj, M.S. Campo, Marchetti, Marchetti, McQueen, O'Brien, Pennie, Piguet, Pizzato, Riteau, Roeth, S.A. Ellis, Storset, Storset, Tindle, Tomasec, Toye, Wang, Williams   +37 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Natural Killer cells responsiveness to physical esercise: a brief review [PDF]

, 2013
Natural killer cells (NK) are a group of peripheral blood lymphocytes which display cytotoxic ac- tivity against a wide range of tumour cells. They are a consistent part of the inflammatory re- sponse that is activated when either internal or external ...
Concu A., CRISAFULLI, ANTONIO, Melis F, MILIA, RAFFAELE, TOCCO, FILIPPO   +4 more
core   +1 more source

Cytotoxic T lymphocytes for leukemia and lymphoma [PDF]

Hematology, 2014
Abstract This chapter focuses on the recent advances in adoptive T-cell immunotherapies, not only for patients after hematopoietic stem cell transplantation, but also in the autologous setting using T cells early in the disease process for the treatment of the highest-risk patients with leukemias and lymphomas. The particular emphasis is
A. John Barrett, Catherine M. Bollard
openaire   +3 more sources