Deep generative selection models of T and B cell receptor repertoires with soNNia [PDF]
, 2020 Subclasses of lymphocytes carry different functional roles to work together to produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens.
arxiv +1 more source
Transition between immune and disease states in a cellular automaton model of clonal immune response [PDF]
, 1997 In this paper we extend the Celada-Seiden (CS) model of the humoral immune response to include infectious virus and cytotoxic T lymphocytes (cellular response). The response of the system to virus involves a competition between the ability of the virus to kill the host cells and the host's ability to eliminate the virus.
arxiv +1 more source
Dynamic model of HIV infection with immune system response of T-lymphocytes, B-cells and dendritic cells: a review [PDF]
arXiv, 2020 A dynamic model of non-lineal time-dependent ordinary differential equations (ODE) has been applied to the interactions of a HIV infection with the immune system cells. This model has been simplified into two compartments: lymph node and peripheral blood.
arxiv
Macroscopic limit of a kinetic model describing the switch in T cell migration modes via binary interactions [PDF]
arXiv, 2020 Experimental results on the immune response to cancer indicate that activation of cytotoxic T lymphocytes (CTLs) through interactions with dendritic cells (DCs) can trigger a change in CTL migration patterns. In particular, while CTLs in the pre-activation state move in a non-local search pattern, the search pattern of activated CTLs is more localised.
arxiv
The Coalescence of Intrahost HIV Lineages Under Symmetric CTL Attack [PDF]
arXiv, 2011 Cytotoxic T lymphocytes (CTLs) are immune system cells that are thought to play an important role in controlling HIV infection. We develop a stochastic ODE model of HIV-CTL interaction that extends current deterministic ODE models. Based on this stochastic model, we consider the effect of CTL attack on intrahost HIV lineages assuming CTLs attack ...
arxiv
Global Properties of Nested Network Model with Application to Multi-Epitope HIV/CTL Dynamics [PDF]
arXiv, 2016 Mathematical modeling and analysis can provide insight on the dynamics of ecosystems which maintain biodiversity in the face of competitive and prey-predator interactions. Of primary interests are the underlying structure and features which stabilize diverse ecological networks.
arxiv
Dynamical Behaviors of the Tumor-immune System in a Stochastic Environment [PDF]
arXiv, 2019 This paper investigates dynamic behaviors of the tumor-immune system perturbed by environmental noise. The model describes the response of the cytotoxic T lymphocyte (CTL) to the growth of an immunogenic tumour. The main methods are stochastic Lyapunov analysis, comparison theorem for stochastic differential equations (SDEs) and strong ergodicity ...
arxiv
Killing of targets by effector CD8$^+$T cells in the mouse spleen follows the law of mass action [PDF]
arXiv, 2009 It has been difficult to measure efficacy of T cell-based vaccines and to correlate efficacy of CD8$^+$T cell responses with protection against viral infections. In part, this difficulty is due to our poor understanding of the in vivo efficacy of CD8$^+$T cells.
arxiv
A Nonconventional Analysis of CD$4^{+}$ and CD$8^{+}$ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection [PDF]
arXiv, 2017 A mathematical model from a previous work was re-fitted and analyzed for experimental data regarding the cellular immune response to the lymphocytic choriomeningitis virus. Specifically, the $CD8^{+}$ T cell response to six MHC class I-restricted epitopes (GP* and NP*) and $CD4^{+}$ T cell responses to two MHC class II-restricted epitopes\cite ...
arxiv
Competition driven cancer immunoediting [PDF]
arXiv, 2014 It is a well-established fact that tumors up-regulate glucose consumption to meet increasing demands for rapidly available energy by switching to purely glycolytic mode of glucose metabolism. What is often neglected is that cytotoxic cells of the immune system also have increased energy demands and also switch to pure glycolysis when they are in an ...
arxiv