Stereoselective Voltammetric Biosensor for Myo-Inositol and D-Chiro-Inositol Recognition [PDF]
Sensors, 2023 This paper describes the development of a simple voltammetric biosensor for the stereoselective discrimination of myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) by means of bovine serum albumin (BSA) adsorption onto a multi-walled carbon ...
Cristina Tortolini +6 more
doaj +5 more sources
D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes [PDF]
Frontiers in Endocrinology, 2021 D-Chiro-Inositol (D-Chiro-Ins) is a secondary messenger in the insulin signaling pathway. D-Chiro-Ins modulates insulin secretion, the mitochondrial respiratory chain, and glycogen storage.
Maria Magdalena Montt-Guevara +6 more
doaj +6 more sources
New Insights into the Activities of D-Chiro-Inositol: A Narrative Review [PDF]
Biomedicines, 2021 D-chiro-inositol (DCI) is a natural compound detectable in cell membranes, which is highly conserved as a biological signaling molecule. In mammals, its function is primarily characterized in the intracellular transduction cascade of insulin.
Riccardo Gambioli +5 more
doaj +5 more sources
Does ovary need D-chiro-inositol? [PDF]
Journal of Ovarian Research, 2012 Backgroud Polycystic Ovary Syndrome (PCOS) is a multifactorial pathology that affects 10% of the women in reproductive age being the main cause of infertility due to menstrual dysfunction.
Isabella Rosalbino, Raffone Emanuela
doaj +6 more sources
D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study. [PDF]
Int J Mol Sci, 2023 Endometrial hyperplasia is a threatening pathology driven by unopposed estrogen stimulus. Moreover, insulin may act on the endometrium, prompting further growth. We aimed at assessing whether D-chiro-Inositol, an insulin sensitizer with estrogen-lowering properties, might improve the condition of patients with simple endometrial hyperplasia without ...
Porcaro G +4 more
europepmc +3 more sources
D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: a pilot study [PDF]
Basic and Clinical Andrology, 2021 Résumé Contexte L’insuffisance en androgènes affecte les hommes à l’âge adulte, causant plusieurs effets nocifs aux niveaux reproductif et comportemental. Puisque l’aromatase est.
Giovanni Monastra +5 more
doaj +2 more sources
The effect of D-chiro-inositol on renal protection in diabetic mice. [PDF]
Aging (Albany NY), 2022 D-Chiro-inositol (DCI) exerts a hypoglycaemic effect, participates in lipid metabolism and reduces kidney damage. In this study, we preliminarily explored the protective effect of DCI on renal injury in diabetic mice. Male db/db mice were used in this study. After treatment with DCI (35 and 70 mg/kg/d) for 6 consecutive weeks, random blood glucose (RBG)
Fan C +6 more
europepmc +3 more sources
Expression of Concern to: Does ovary need D-chiro-inositol? [PDF]
Journal of Ovarian Research, 2018 Rosalbino Isabella, Emanuela Raffone
doaj +10 more sources
D-Chiro-Inositol and LPS Induce a PCOS-Like Hyperandrogenic Response in Human KGN Granulosa Cells. [PDF]
J Cell Mol MedABSTRACT Hyperandrogenism is a key hallmark of polycystic ovary syndrome, a prevalent endocrine disorder affecting women of reproductive age and often leading to infertility. We previously observed that high doses of D‐chiro‐inositol in mice reduce ovarian aromatase expression, contributing to a hyperandrogenic state.
Giuliani C +4 more
europepmc +2 more sources
Long-Lasting Therapies with High Doses of D-chiro-inositol: The Downside. [PDF]
J Clin Med, 2023 Background: Recent studies reported possible concerns following long-lasting treatments with high doses of D-chiro-inositol in women. However, to date, no clinical trial has investigated or validated these concerns. We addressed this issue both retrospectively and with a prospective pilot study.
Nordio M +4 more
europepmc +3 more sources