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Supplementation with d-chiro-inositol in women
2023The world of natural compounds has been investigated with the aim of discovering possible medical applications ever since the origin of medicine. Recently, the field of gynecology has developed a growing interest regarding inositols. Inositols are cyclic polyols with a key role in many metabolic pathways.
Laganà AS, Aragona C, Prapas N
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Gynecological Endocrinology, 2014 Myo-inositol and d-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients. The aim of this work is to compare the effects of myo-inositol and d-chiro-inositol in PCOS.
Antonio Simone Laganà
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Synthesis of galactosaminyl d-chiro-inositols
Carbohydrate Research, 2006All six isomeric D-galactosaminopyranosyl-D-chiro-inositols have been prepared by glycosylation of appropriate penta-O-benzyl-D-chiro-inositols. The three requisite protected D-chiro-inositols were prepared by SmI2-promoted pinacol coupling of dialdehydes derived ultimately from L-arabinose.
Georgia, Marnera, Marc, d'Alarcao
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The D-chiro-inositol paradox in the ovary
Fertility and Sterility, 2011The D-chiro-inositol-to-myo-inositol ratio is regulated by an insulin-dependent epimerase. Enzyme activity varies among tissues, likely owing to the specific needs of the two different molecules. We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in ...
Gianfranco, Carlomagno +2 more
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Placental expression of d-chiro-inositol phosphoglycans in preeclampsia
Placenta, 2012Abnormalities in glucose metabolism linked to D-chiro-inostol phosphoglycans (IPGs) have been described in human placentas of preeclamptic women. In this study, a semi-quantitative approach to assess the histological assessment of IPGs revealed no significant differences between early and late onset preeclampsia and gestational age matched controls ...
M, Scioscia +3 more
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Expert Opinion on Drug Metabolism and Toxicology, 2019 Background: D-chiro-inositol (DCI) and glucose transporter inhibitors may inhibit myo-inositol (MI) transporters, and the aim is to clinically evaluate their effect on MI absorption.
Simone Garzon +2 more
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D‐Chiro‐Inositol Phosphate in a Forest Soil
Soil Science Society of America Journal, 1972Abstract The previously unidentified “D,L”‐chiro‐inositol phosphate (L'Annunziata and Fuller, 1971) of a Tucson forest soil was identified as the dextrorotatory D‐chiro‐inositol phosphate. An infrared spectrum of the inositol moiety was obtained as evidence for the chiro isomer, additional to the previously ...
Michael F. L'Annunziata +2 more
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Myoinositol or D-chiro-inositol for PCOS symptoms in adolescents: a narrative review
Journal of Pediatric Endocrinology and Metabolism, 2023Abstract Background Polycystic ovary syndrome (PCOS) treatment in adolescents currently focuses on lifestyle interventions, with pharmacological treatment options often limited to hormonal contraceptives.
Bibi Zeyah Fatemah Sairally +3 more
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Experimental Biology and Medicine, 2003 Inositol phosphoglycan molecules containing either d-chiro-inositol or myo-inositol have been isolated from various mammalian tissues and are putative mediators of insulin action. Urinary excretion of inositols appears to be altered in diabetes mellitus;
Carla G. Taylor, Roman Przybylski
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Synthesis of fagopyritols A1 and B1 from d-chiro-inositol
Carbohydrate Research, 2004Fagopyritol A1 (3-O-alpha-d-galactopyranosyl-d-chiro-inositol) and fagopyritol B1 (2-O-alpha-d-galactopyranosyl-d-chiro-inositol) have been synthesized by glycosylation of the diequatorial diol 1,4,5,6-tetra-O-benzoyl-d-chiro-inositol, readily obtained from d-chiro-inositol, with 2,3,4,6-tetra-O-benzyl-d-galactopyranosyl trichloroacetimidate.
M Belén, Cid +2 more
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