Molecules, 2020 (1) Background: Myoinositol (MI) and D-chiro-inositol (DCI) are involved in a number of biochemical pathways within oocytes having a role in oocyte maturation, fertilization, implantation, and post-implantation development.
Zdravko A Kamenov, Antoaneta Gateva
exaly +5 more sources
The Role of Inositols in Endocrine and Neuroendocrine Tumors [PDF]
BiomoleculesInositols have demonstrated a role in cancer prevention and treatment in many kinds of neoplasms. Their molecular mechanisms vary from the regulation of survival and proliferative pathways to the modulation of immunity and oxidative stress.
Giulia Puliani +2 more
exaly +4 more sources
Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials [PDF]
Reproductive Biology and Endocrinology, 2023 Background Metformin is the gold standard insulin sensitizer, which is widely used to treat insulin resistance in polycystic ovary syndrome (PCOS). However, metformin may induce gastrointestinal side effects. Objective Inositols have long been debated as
Dorina Greff +11 more
doaj +2 more sources
Journal of Mid-Life Health, 2018 This review describes the mechanistic, animal, and clinical data related to the use of inositols in midlife. It covers studies related to the mechanism of action of myo-inositol and D-chiro-inositol and randomized controlled trials conducted in ...
Sanjay Kalra, Bharti Kalra
doaj +3 more sources
Physiological, Biochemical, and Structural Bioinformatic Analysis of the Multiple Inositol Dehydrogenases from Corynebacterium glutamicum [PDF]
Microbiology Spectrum, 2022 Inositols (cyclohexanehexols) comprise nine isomeric cyclic sugar alcohols, several of which occur in all domains of life with various functions. Many bacteria can utilize inositols as carbon and energy sources via a specific pathway involving inositol ...
Paul Ramp +5 more
doaj +2 more sources
Role of Inositols and Inositol Phosphates in Energy Metabolism [PDF]
Molecules, 2020 Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects.
Saimai Chatree +4 more
doaj +3 more sources
Metabolism of inositol derivatives by the gut microbiome [PDF]
Gut MicrobesThe gut microbiome harbors immense metabolic capacity, much of which is still being uncovered. Recent discoveries have highlighted the ability of gut microbes to metabolize inositol-derived compounds, including free inositols and their phosphorylated ...
Henning Jessen, Thi Phuong Nam Bui
doaj +2 more sources
Impact of Hydrogel-to-Oleogel Ratio and Presence of Carob Fruit Extracts on Formulated Bigels: Rheological, Thermal, Physicochemical and Microstructural Properties [PDF]
FoodsThis study explores the development of bigels (BGs) combining a hydrophilic hydrogel (HG) and a lipophilic oleogel (OG) for co-delivery of two carob fruit extracts (CFEs): I-CFE (inositols) and P-CFE (phenolics).
María Dolores Álvarez +2 more
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Preventing epileptogenesis by interaction between inositol isomers and proteins [PDF]
Epilepsia OpenObjective Inositols play significant roles in biological systems. Myo‐inositol (MI), the most prevalent isomer, functions as an osmolyte and mediates cell signal transduction. Other notable isomers include Scyllo‐inositol (SCI) and D‐Chiro‐inositol (DCHI)
Lia Tsverava +7 more
doaj +2 more sources
Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance [PDF]
Neural Regeneration ResearchAlzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease. The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau ...
Dina Medina-Vera +6 more
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