Results 21 to 30 of about 1,468 (246)

PCOS and Assisted Reproduction Technique: Role and Relevance of Inositols

Endocrines, 2021
Polycystic ovary syndrome is an endocrine disorder often characterized by insulin resistance and hyperinsulinemia, especially in overweight/obese women. Among insulin sensitizers, the positive role of inositols has been increasingly established in recent
Paolo Giovanni Artini, Elisa Malacarne, Vito Cela   +2 more
doaj   +1 more source

Putative Complementary Compounds to Counteract Insulin-Resistance in PCOS Patients

Biomedicines, 2022
Polycystic ovary syndrome (PCOS) is the most frequent endocrine-metabolic disorder among women at reproductive age. The diagnosis is based on the presence of at least two out of three criteria of the Rotterdam criteria (2003).
Tabatha Petrillo, Elisa Semprini, Veronica Tomatis, Melania Arnesano, Fedora Ambrosetti, Christian Battipaglia, Alessandra Sponzilli, Francesco Ricciardiello, Andrea R. Genazzani, Alessandro D. Genazzani   +9 more
doaj   +1 more source

Novel Chemical and Biological Insights of Inositol Derivatives in Mediterranean Plants

Molecules, 2022
Inositols (Ins) are natural compounds largely widespread in plants and animals. Bio-sinthetically they derive from sugars, possessing a molecular structure very similar to the simple sugars, and this aspect concurs to define them as primary metabolites ...
Laura Siracusa, Edoardo Napoli, Giuseppe Ruberto   +2 more
doaj   +1 more source

INOSITOLS: BIOLOGICAL ROLE AND APPLICATION, METHODS OF EXTRACTION FROM PLANT RAW MATERIALS AND DETERMINATION, BIOTECHNOLOGICAL SYNTHESIS [PDF]

Biotechnologia Acta
The aim of the work was to review modern extraction, detection and quantification analytical methods of inositols and their derivatives. Methods. Inositols are extracted from vegetable raw materials by methods of liquid extraction, under pressure ...
V. A. RAKS, O. A. VASYLCHENKO , O. V. MYRONIUK, A. O. BILOUSOVA, О. M. LYSENKO, N. V. KURDIL   +5 more
doaj   +1 more source

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]

Proceedings of the National Academy of Sciences, 2001
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
A, Saiardi, E, Nagata, H R, Luo, A, Sawa, X, Luo, A M, Snowman, S H, Snyder   +6 more
openaire   +2 more sources

Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate

International Journal of Endocrinology, 2016
Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathological settings. Deregulated inositol metabolism has been recorded in a number of diseases, including cancer, where inositol ...
Mariano Bizzarri, Simona Dinicola, Arturo Bevilacqua, Alessandra Cucina   +3 more
doaj   +1 more source

Inositols in reproductive medicine

Репродуктивная эндокринология, 2020
The article presents literature data on the role of inositol and its derivatives in human body, results of the myo-inositol (MI) use in gynecological diseases, treatment of female and male infertility, including in cycles of assisted reproductive ...
O. M. Nosenko, O. V. Novikova
doaj   +1 more source

Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome

The EuroBiotech Journal, 2018
It has been known that inositols function as insulin second messengers and mediate different insulin-dependent processes and are a valid natural, non-pharmaceutical alternative to contrast insulin-resistance as well as associated metabolic syndrome in ...
Malvasi Antonio, Tinelli Andrea, Baldini Domenico, Iannitti Rossana G., Fioretti Bernard   +4 more
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Inhibitors of Inositol Monophosphatase [PDF]

Journal of Enzyme Inhibition, 1999
Inositol monophosphatase (IMPase) catalyses the hydrolysis of myo-inositol monophosphates to myo-inositol, which is required in the phosphatidyl inositol cell signalling pathway. Here the enzyme structure, mechanism and inhibition of IMPase are reviewed. Lithium, an effective therapy for manic depression, is an uncompetitive inhibitor.
Fauroux, Christine M J, Freeman, Sally
openaire   +3 more sources

Inositols and metabolic disorders: From farm to bedside

Journal of Traditional and Complementary Medicine, 2020
Inositol and its derivates are catching interest in metabolism since taking part in several physiological processes, including endocrine modulation. Through several mechanisms mostly mediated by insulin signaling, these compounds regulate the activities ...
M. Caputo, E. Bona, I. Leone, M.T. Samà, A. Nuzzo, A. Ferrero, G. Aimaretti, P. Marzullo, F. Prodam   +8 more
doaj   +1 more source