D-chiro-inositol effectively counteracts endometriosis in a mouse model. [PDF]
Mol MedAbstract Background Endometriosis, a common condition affecting 5–10% of women of reproductive age, is the growth of endometrial-like tissue outside the uterus, leading to pain and infertility. Current treatments, such as surgery and hormonal therapy, offer limited long-term benefits.
Placidi M +10 more
europepmc +6 more sources
D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence. [PDF]
J Clin Med, 2020 The use of inositols in endocrinological clinical practice is increasingly widespread. Most of the existing evidence concerns myoinositol (MYO), the most abundant form in nature, especially in women with polycystic ovarian syndrome. We have previously shown that MYO increases sperm motility in patients with asthenozoospermia by the increase of sperm ...
Condorelli RA +5 more
europepmc +4 more sources
The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes [PDF]
International Journal of Endocrinology, 2016 Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance.
Basilio Pintaudi +2 more
doaj +2 more sources
Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data [PDF]
International Journal of Endocrinology, 2016 Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome.
Mario Mancini +5 more
doaj +2 more sources
The effect of myo-inositol on assisted reproductive technology outcomes in women with polycystic ovarian syndrome: A systematic review and meta-analysis of randomized clinical trial studies [PDF]
International Journal of Reproductive BioMedicineBackground: Conflicting evidence from clinical trials on the effects of myo-inositol and D-chiro-inositol on assisted reproductive technology (ART) outcomes in women with polycystic ovarian syndrome (PCOS) necessitates a systematic review and meta ...
Azadeh Akbari Sene +6 more
doaj +2 more sources
D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells. [PDF]
Mol Cell Endocrinol, 2014 Insulin has been shown to act on pancreatic β cells to regulate its own secretion. Currently the mechanism underlying this effect is unclear. INS-2, a novel inositol glycan pseudo-disaccharide containing D-chiro-inositol and galactosamine, has been shown to function as an insulin mimetic and a putative insulin mediator.
Lazarenko R +4 more
europepmc +4 more sources
Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials [PDF]
Frontiers in EndocrinologyObjectivesThis umbrella review aimed to synthesize and appraise the evidence regarding the efficacy of inositol for Polycystic Ovary Syndrome (PCOS) by integrating meta-analyses of randomized controlled trials(RCTs), thereby assessing the robustness of ...
Mengxue Duan +11 more
doaj +2 more sources
Role of inositol and its isomers in glucose metabolism
Репродуктивная эндокринология, 2021 Despite the chemical similarities between myo-inositol and D-chiro-inositol and their synergistic effects on insulin sensitivity, they serve different functions.
O.A. Nochvinа, E.V. Slyvka
doaj +1 more source
Inositol Treatment for PCOS Should Be Science-Based and Not Arbitrary
International Journal of Endocrinology, 2020 The aim of this paper is to critically analyze the composition of many inositol-based products currently used to treat Polycystic Ovary Syndrome (PCOS).
Scott Roseff, Marta Montenegro
doaj +2 more sources
A double-edge sword: the role of D-chiro-inositol in oocyte and embryo quality [PDF]
International Journal of Medical Device and Adjuvant Treatments, 2019 D-chiro-inositol is one of the nine stereoisomers of inositol, a water-soluble cyclic carbohydrate with six hydroxyl groups. Inositol has an essential function in the activation of crucial enzymes in glucose metabolism. In fact, D-chiro-inositol shortage
M. Minini, G. Monastra, S. Dinicola
doaj +1 more source