Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies [PDF]
Frontiers in ChemistryIntroduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in a chick model.
Mohammed Alfaifi +2 more
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D-Pinitol Improved Glucose Metabolism and Inhibited Bone Loss in Mice with Diabetic Osteoporosis [PDF]
Molecules, 2023 Diabetic osteoporosis (DO) has been increasingly recognized as an important complication of diabetes. D-pinitol, a natural compound found in various legumes, is known for its anti-diabetic function, but its effect on DO has not been investigated.
Xinxin Liu, Tomoyuki Koyama
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D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five Bougainvillea spectabilis Willd. Cultivars [PDF]
Pharmaceuticals, 2023 Diabetes mellitus is a major challenge for global health, and Bougainvillea spectabilis Willd. (B. spectabilis) is a widely used herbal remedy with diverse cultivars traditionally used for diabetes treatment.
Fatma Abo-Elghiet +7 more
doaj +2 more sources
initol protects against endoplasmic reticulum stress and apoptosis in hepatic ischemia-reperfusion injury via modulation of AFT4-CHOP/GRP78 and caspase-3 signaling pathways [PDF]
International Journal of Immunopathology and Pharmacology, 2021 Hepatic ischemia-reperfusion injury (IRI) is a major unavoidable clinical problem often accompanying various liver surgery and transplantation. d-P initol, a cyclic polyol, exhibits hepatoprotective efficacy.
Lei Yan +3 more
doaj +2 more sources
Neuroprotective Effect of D-Pinitol Against MPTP-Induced Parkinsonism in C57BL/6J Mice [PDF]
AntioxidantsParkinson’s disease is the second most common neurodegenerative disease in the world. Natural products can offer a possible option of neuroprotective agents for preventing neurodegenerative diseases.
María del Carmen Juárez-Vázquez +9 more
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Integrated proteomics and metabolomics analysis of D-pinitol function during hippocampal damage in streptozocin-induced aging-accelerated mice [PDF]
Frontiers in Molecular Neuroscience, 2023 PurposeDiabetes can cause hippocampal damage and lead to cognitive impairment. Diabetic cognitive impairment (DCI) is a chronic complication of diabetes associated with a high disability rate; however, its pathogenesis and therapeutic targets are unclear.
Xiaoxia Li +27 more
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Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery [PDF]
Frontiers in Pharmacology, 2018 D-pinitol is a cyclitol present in several edible plant species and extensively investigated for the treatment of metabolic diseases in humans, as food supplement, and demonstrated protective effects in the cardiovascular system.
Luciana N. Moreira +4 more
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D-Pinitol improves cognitive dysfunction and neuronal damage induced by isoproterenol via modulation of NF-κB/BDNF/GFAP signaling in Swiss albino mice [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Neurological disorders are the world’s most distressing problem. The adverse effects of current medications continue to compel scientists to seek safer, more effective, and economically affordable alternatives. In this vein, we explored the
Aamir Khan +5 more
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NMR Identification and Quantification of Galactinol in Green Coffea arabica: Implications for Traceability and Adulteration. [PDF]
J Food SciABSTRACT Among coffee low‐molecular‐weight carbohydrates, galactinol plays an important role in coffee physiology and quality, having received attention also for its potential use as a marker of geographical origin. Nevertheless, data on the occurrence of this sugar in green coffee beans remain limited.
De Angelis E +7 more
europepmc +2 more sources
Isolation and quantification of pinitol in Argyrolobium roseum plant, by 1H-NMR
Journal of Saudi Chemical Society, 2016 Chemical investigations on ethanolic extract of Argyrolobium roseum led to the isolation of Pinitol as the major constituent of the plant. Pinitol is chemically known as 3-O-methyl-D-Chiro-inositol and has been found to possess anti-diabetic activity. It
Neha Sharma +2 more
exaly +3 more sources