Effects of d-pinitol on diabetes mellitus: an updated review
Bulletin of the National Research Centre, 2022 Background The awareness in the consumption of plant-based food has gained attention in the recent years. Phytochemicals are thought to play a critical role in health promotion and in the prevention and management of chronic diseases.
Anandakumar Pandi +2 more
doaj +2 more sources
Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats
Asian Pacific Journal of Tropical Biomedicine, 2023 Objective: To assess the effect of D-pinitol on pulmonary fibrosis induced by bleomycin. Methods: Sprague-Dawley rats received intratracheal bleomycin (6 IU/kg) to induce pulmonary fibrosis, followed by administration of either D-pinitol (5, 10, or 20 mg/
Yu-Ling Duan +6 more
doaj +2 more sources
Neuropharmacological and Antipyretic Potentials of Streblus asper Leaves: Integrated In Vivo and In Silico Approaches. [PDF]
ScientificWorldJournalStreblus asper (Moraceae) is traditionally used for neurological and febrile disorders, but its pharmacological basis remains unclear. This study evaluated the S. asper leaf methanolic extract (SAL‐ME) for anxiolytic, antidepressant, sedative, and antipyretic activities using Swiss albino mice and in silico docking analyses.
Rasel MH +5 more
europepmc +2 more sources
The regulation of MFG‐E8 on the mitophagy in diabetic sarcopenia via the HSPA1L‐Parkin pathway and the effect of D‐pinitol [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Diabetic sarcopenia is a disease‐related skeletal muscle disorder that causes progressive symptoms. The complete understanding of its pathogenesis is yet to be unravelled, which makes it difficult to develop effective therapeutic strategies ...
Wenqian Zhao +12 more
doaj +2 more sources
D-Pinitol Mitigates Renal Senescence via Targeting the SARM1-cGAS-STING Signaling Axis to Restore Mitochondrial Function and Dampen Inflammatory Responses [PDF]
BiomedicinesBackground: Renal aging represents a pivotal contributor to the pathogenesis and progression of age-related kidney disorders. D-Pinitol (DP), a bioactive cyclitol naturally present in food plants, exhibits multiple beneficial biological activities ...
Xiaofan Yin +4 more
doaj +2 more sources
Pinitol Improves Lipopolysaccharide-Induced Cellular Damage in Human Dermal Microvascular Endothelial Cells [PDF]
Molecules3-O-Methyl-D-chiro-inositol (pinitol) has been reported to possess insulin-like effects and is known as one of the anti-diabetic agents for improving muscle and liver function.
Min Young Go +4 more
doaj +2 more sources
Isolation and quantification of pinitol in Argyrolobium roseum plant, by 1H-NMR
Journal of Saudi Chemical Society, 2016 Chemical investigations on ethanolic extract of Argyrolobium roseum led to the isolation of Pinitol as the major constituent of the plant. Pinitol is chemically known as 3-O-methyl-D-Chiro-inositol and has been found to possess anti-diabetic activity. It
Neha Sharma, M K Verma, Naresh K Satti
exaly +3 more sources
PHYSICOCHEMICAL PROPERTIES OF CAROB SYRUP REVEAL D-PINITOL AS AN INDEX OF SUCROSE SUPPLEMENTATION
Food and Environment Safety, 2021 The carob syrup has been attracted the interest of consumers as an alternative sweetener due to its superiority against refined ones. Bioactive phytochemicals and polyols, vitamins and minerals are present in carob syrup; whereas sucrose, fructose and ...
Vlasios GOULAS, Polina ARESTI
doaj +3 more sources
D-Pinitol-Active Natural Product from Carob with Notable Insulin Regulation. [PDF]
Nutrients, 2022 Carob is one of the major food trees for peoples of the Mediterranean basin, but it has also been traditionally used for medicinal purposes. Carob contains many nutrients and active natural products, and D-Pinitol is clearly one of the most important of these.
Azab A.
europepmc +3 more sources
Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers. [PDF]
Nutrients, 2022 The present study characterizes the oral pharmacokinetics of D-Pinitol, a natural insulin mimetic inositol, in human healthy volunteers (14 males and 11 females). D-Pinitol absorption was studied in (a) subjects receiving a single oral dose of 15 mg/kg (n = 10), or (b) 5 mg/kg pure D-Pinitol (n = 6), and (c) subjects receiving D-Pinitol as part of ...
Navarro JA +15 more
europepmc +5 more sources