Neuropharmacological and Antipyretic Potentials of Streblus asper Leaves: Integrated In Vivo and In Silico Approaches. [PDF]
ScientificWorldJournalStreblus asper (Moraceae) is traditionally used for neurological and febrile disorders, but its pharmacological basis remains unclear. This study evaluated the S. asper leaf methanolic extract (SAL‐ME) for anxiolytic, antidepressant, sedative, and antipyretic activities using Swiss albino mice and in silico docking analyses.
Rasel MH +5 more
europepmc +2 more sources
D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks [PDF]
Pharmaceutical Science AdvancesNaturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs ...
Md. Elit Rahman +15 more
doaj +2 more sources
The regulation of MFG‐E8 on the mitophagy in diabetic sarcopenia via the HSPA1L‐Parkin pathway and the effect of D‐pinitol [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Diabetic sarcopenia is a disease‐related skeletal muscle disorder that causes progressive symptoms. The complete understanding of its pathogenesis is yet to be unravelled, which makes it difficult to develop effective therapeutic strategies ...
Wenqian Zhao +12 more
doaj +2 more sources
D-Pinitol Mitigates Renal Senescence via Targeting the SARM1-cGAS-STING Signaling Axis to Restore Mitochondrial Function and Dampen Inflammatory Responses [PDF]
BiomedicinesBackground: Renal aging represents a pivotal contributor to the pathogenesis and progression of age-related kidney disorders. D-Pinitol (DP), a bioactive cyclitol naturally present in food plants, exhibits multiple beneficial biological activities ...
Xiaofan Yin +4 more
doaj +2 more sources
Pinitol Improves Lipopolysaccharide-Induced Cellular Damage in Human Dermal Microvascular Endothelial Cells [PDF]
Molecules3-O-Methyl-D-chiro-inositol (pinitol) has been reported to possess insulin-like effects and is known as one of the anti-diabetic agents for improving muscle and liver function.
Min Young Go +4 more
doaj +2 more sources
Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers [PDF]
Nutrients, 2022 Juan A Navarro +2 more
exaly +2 more sources
Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats
Asian Pacific Journal of Tropical Biomedicine, 2023 Objective: To assess the effect of D-pinitol on pulmonary fibrosis induced by bleomycin. Methods: Sprague-Dawley rats received intratracheal bleomycin (6 IU/kg) to induce pulmonary fibrosis, followed by administration of either D-pinitol (5, 10, or 20 mg/
Yu-Ling Duan +6 more
doaj +1 more source
D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice [PDF]
Anais da Academia Brasileira de Ciências, 2020 D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic and hypolipidemic actions in diabetic rodents. Here, we investigated the actions of D-pinitol on adiposity, and in lipid and glycemic homeostasis in ...
JOEL A. DA SILVA JÚNIOR +7 more
doaj +1 more source
Effects of d-pinitol on diabetes mellitus: an updated review
Bulletin of the National Research Centre, 2022 Background The awareness in the consumption of plant-based food has gained attention in the recent years. Phytochemicals are thought to play a critical role in health promotion and in the prevention and management of chronic diseases.
Anandakumar Pandi +2 more
doaj +1 more source
Turkish Journal of Agriculture: Food Science and Technology, 2020 Bu çalışmada keçiboynuzu ekstraktında bulunan D-pinitolün 1-5 kDa ayırma sınırı aralığında nanofiltreler kullanılarak zenginleştirilmesi amaçlanmıştır.
Ahmet Hacıoğlu +5 more
doaj +1 more source