Results 31 to 40 of about 17,216 (256)

Damage‐associated molecular patterns (DAMPs) and mesenchymal stem cells: A matter of attraction and excitement [PDF]

European Journal of Immunology, 2011
AbstractNecrotic cell death is a typical feature of solid tumors leading to the release of necrotic products, also known as damage‐associated molecular patterns (DAMPs), that enhance angiogenesis and prime the immune response. Among the DAMPs, particular attention has been focused on the DNA‐binding molecule high‐mobility group box 1 (HMGB‐1) that can ...
Vito, Pistoia, Lizzia, Raffaghello
openaire   +2 more sources

Recognition of Elicitors in Grapevine: From MAMP and DAMP Perception to Induced Resistance

Frontiers in Plant Science, 2019
In a context of a sustainable viticulture, the implementation of innovative eco-friendly strategies, such as elicitor-triggered immunity, requires a deep knowledge of the molecular mechanisms underlying grapevine defense activation, from pathogen ...
Marie-Claire Héloir, Marielle Adrian, Daphnée Brulé, Justine Claverie, Sylvain Cordelier, Xavier Daire, Stéphan Dorey, Adrien Gauthier, Adrien Gauthier, Christelle Lemaître-Guillier, Jonathan Negrel, Lucie Trdá, Lucie Trdá, Sophie Trouvelot, Elodie Vandelle, Elodie Vandelle, Benoit Poinssot   +16 more
doaj   +1 more source

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

Journal of Inflammation, 2012
Background Toll-like receptor 4 (TLR4) is activated by bacterial endotoxin, a prototypical pathogen-associated molecular pattern (PAMP). It has been suggested that TLR4 can also be activated by damage-associated molecular pattern (DAMP) proteins such as ...
Luong Michael, Zhang Yanyu, Chamberlain Tim, Zhou Tianhui, Wright Jill F, Dower Ken, Hall J Perry   +6 more
doaj   +1 more source

Damage-associated molecular patterns (DAMPs) in vascular diseases

Journal of Biological Chemistry
Research into the role of chronic sterile inflammation (i.e., a prolonged inflammatory state not caused by an infectious agent) in vascular disease progression has continued to grow over the last few decades. DAMPs have a critical role in this research due to their ability to link stress-causing cardiovascular risk factors to inflammatory phenotypes ...
Jacob Antonello, Partha Roy
openaire   +2 more sources

Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid.

PLoS Pathogens, 2016
Damage-associated molecular pattern molecules (DAMPs) signal the presence of tissue damage to induce immune responses in plants and animals. Here, we report that High Mobility Group Box 3 (HMGB3) is a novel plant DAMP.
Hyong Woo Choi, Murli Manohar, Patricia Manosalva, Miaoying Tian, Magali Moreau, Daniel F Klessig   +5 more
doaj   +1 more source

DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway.

PLoS Pathogens, 2014
Pathogen-associated molecular patterns (PAMPs) trigger host immune response by activating pattern recognition receptors like toll-like receptors (TLRs).
Su-Yu Tsai, Jesus A Segovia, Te-Hung Chang, Ian R Morris, Michael T Berton, Philippe A Tessier, Mélanie R Tardif, Annabelle Cesaro, Santanu Bose   +8 more
doaj   +1 more source

Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

Disease Models & Mechanisms, 2015
Increased urinary albumin excretion is not simply an aftermath of glomerular injury, but is also involved in the progression of diabetic nephropathy (DN).
Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A. Lai, Junne-Ming Sung, Yau-Sheng Tsai   +11 more
doaj   +1 more source

Toll-Like Receptors 1/2/4/6 and Nucleotide-Binding Oligomerization Domain-Like Receptor 2 Are Key Damage-Associated Molecular Patterns Sensors on Periodontal Resident Cells

Applied Sciences, 2021
Background: Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are innate, damage-associated molecular patterns (DAMP) sensors.
Yu Chen, Xiao Xiao Wang, Corrie H. C. Ng, Sai Wah Tsao, Wai Keung Leung   +4 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source