Results 21 to 30 of about 17,216 (256)
Inflammaging as the basis of age-associated diseases
Медицинская иммунология, 2020 Aging is one of the most complex biological phenomena that affects all human physiological systems, including the immune system. Immunosenescence is understood as structural and functional changes in both adaptive and innate immunity systems.
O. V. Artemyeva, L. V. Gankovskaya
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International Journal of Molecular Sciences, 2023 Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL.
María José Caballero-Herrero +4 more
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The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature [PDF]
Frontiers in Medicine, 2021 During the osteoarthritis (OA) process, activation of immune systems, whether innate or adaptive, is strongly associated with low-grade systemic inflammation. This process is initiated and driven in the synovial membrane, especially by synovium cells, themselves previously activated by damage-associated molecular patterns (DAMPs) released during ...
Cécile Lambert +6 more
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Frontiers in Cell and Developmental Biology, 2019 Chronic ER stress occurs when protein misfolding in the Endoplasmic reticulum (ER) lumen remains unresolved despite activation of the unfolded protein response.
Alexander Andersohn +8 more
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Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy?
Frontiers in Oncology, 2021 Combinatory treatments using surgery, radiotherapy and/or chemotherapy together with immunotherapy have shown encouraging results for specific subsets of tumors, but a significant proportion of tumors remains unsusceptible.
Thijs A. van Schaik +6 more
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Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH) [PDF]
International Journal of Molecular Sciences, 2018 Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes, but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical clipping and endovascular coiling can successfully obliterate the bleeding aneurysms, but ensuing complications such as cerebral vasospasm, acute and chronic hydrocephalus ...
Shafqat Rasul Chaudhry +6 more
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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
Molecular Medicine, 2013 Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), is an abundant architectural chromosomal ...
Ruochan Chen +5 more
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Immunogenic cell death as driver of autoimmunity in granulomatosis with polyangiitis
Frontiers in Immunology, 2022 Cell death and dysregulated clearance of dead cells play essential roles in the induction of chronic inflammatory processes and autoimmune diseases. Granulomatosis with polyangiitis (GPA), a neutrophil-driven autoimmune disorder, is characterized by ...
Christoph Brieske +2 more
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Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
Frontiers in Immunology, 2017 Inflammation is increasingly implicated in neurodegenerative disease pathology. As no acquired pathogen appears to drive this inflammation, the question of what does remains.
Russell H. Swerdlow +9 more
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Cell-Free Mitochondrial DNA in Acute Brain Injury
Neurotrauma Reports, 2022 Traumatic brain injury and aneurysmal subarachnoid haemorrhage are a major cause of morbidity and mortality worldwide. Treatment options remain limited and are hampered by our understanding of the cellular and molecular mechanisms, including the ...
Saeed Kayhanian +6 more
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