Results 11 to 20 of about 17,216 (256)

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy

Molecular Biomedicine
Damage-associated molecular patterns (DAMPs) are endogenous danger signal molecules released by damaged, stressed or dead cells that bind to pattern recognition receptors (PRRs), activating immune responses and inflammatory signaling pathways to play ...
Heya Lin, Wei Xiong, Lili Fu, Jie Yi, Jiantang Yang   +4 more
doaj   +4 more sources

Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders [PDF]

International Journal of Molecular Sciences, 2022
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma ...
Binapani Mahaling, Shermaine W. Y. Low, Molly Beck, Devesh Kumar, Simrah Ahmed, Thomas B. Connor, Baseer Ahmad, Shyam S. Chaurasia   +7 more
openaire   +2 more sources

In silico selection of damage-associated molecular patterns (DAMPS) and their receptors in humans

Research, Society and Development, 2022
Damage-associated molecular patterns (DAMPs) are intracellular molecules released into the extracellular environment after injury. These are recognized by pattern recognition receptors (PRRs) and activate the innate immune system, triggering an inflammatory response.
Erika Aparecida Oliveira, Rebeca Louise de Araujo Brabosa, Wanderley José Mantovani Bittencourt, Laura Cristina Jardim Porto Pimenta, Luciano José Pereira, Elaine Maria Seles Dorneles, Ana Paula Peconick   +6 more
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Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases [PDF]

Mitochondrion, 2018
Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues and fostering repair of damaged tissues back to homeostatic levels. In normal physiologic context, inflammatory response culminates with the resolution of infection and tissue damage response ...
Charles S. Dela Cruz, Min-Jong Kang
openaire   +2 more sources

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Rheumatology & Autoimmunity, 2022
AbstractAll organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs). In addition to well‐characterized DAMPs such as high‐mobility group box 1 and adenosine triphosphate ...
Na Kang, Xiaohang Liu, Kabeer Haneef, Wanli Liu   +3 more
openaire   +2 more sources

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

American Journal of Transplantation, 2016
Upon solid organ transplantation and during cancer immunotherapy, cellular stress responses result in the release of damage-associated molecular patterns (DAMPs). The various cellular stresses have been characterized in detail over the last decades, but a unifying classification based on clinically important aspects is lacking.
Land, W.G., Agostinis, Patrizia, Gasser, S., Garg, Abhishek, Linkermann, A.   +4 more
openaire   +3 more sources

Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases

Cells, 2022
Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)-associated molecular patterns (DAMPs/alarmins) in the pathogenesis of these diseases has been ...
Ken Fukuda, Waka Ishida, Tatsuma Kishimoto, Isana Nakajima, Yusaku Miura, Tamaki Sumi, Kenji Yamashiro   +6 more
openaire   +3 more sources

The Rice Endophyte-Derived α-Mannosidase ShAM1 Degrades Host Cell Walls To Activate DAMP-Triggered Immunity against Disease

Microbiology Spectrum, 2023
Endophytes play an important role in shaping plant growth and immunity. However, the mechanisms for endophyte-induced disease resistance in host plants remain unclear.
Zhigang Bu, Wei Li, Xiaoli Liu, Ying Liu, Yan Gao, Gang Pei, Rui Zhuo, Kunpeng Cui, Ziwei Qin, Heping Zheng, Jie Wu, Yutong Yang, Pin Su, Meiting Cao, Xianqiu Xiong, Xuanming Liu, Yonghua Zhu   +16 more
doaj   +1 more source

Danger signals - damaged-self recognition across the tree of life

Frontiers in Plant Science, 2014
Multicellular organisms suffer injury and serve as hosts for microorganisms. Therefore, they require mechanisms to detect injury and to distinguish the self from the non-self and the harmless non-self (microbial mutualists and commensals) from the ...
Martin eHeil, Walter G Land
doaj   +1 more source

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

Neurobiology of Disease, 2013
Toll-like receptor 4 (TLR4) activation in neuron and astrocytes by High Mobility Group Box 1 (HMGB1) protein is a key mechanism of seizure generation. HMGB1 also activates the Receptor for Advanced Glycation Endproducts (RAGE), but it was unknown whether
Valentina Iori, Mattia Maroso, Massimo Rizzi, Anand M. Iyer, Roberta Vertemara, Mirjana Carli, Alessandra Agresti, Antonella Antonelli, Marco E. Bianchi, Eleonora Aronica, Teresa Ravizza, Annamaria Vezzani   +11 more
doaj   +1 more source