Results 1 to 10 of about 17,067 (111)

Extracellular ATP acts as a damage associated molecular pattern (DAMP) signal in plants [PDF]

Frontiers in Plant Science, 2014
As sessile organisms, plants have evolved effective mechanisms to protect themselves from environmental stresses. Damaged (i.e., wounded) plants recognize a variety of endogenous molecules as danger signals, referred to as damage-associated molecular ...
Kiwamu eTanaka, Jeongmin eChoi, Yangrong eCao, Gary eStacey   +3 more
doaj   +4 more sources

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors [PDF]

Cells, 2022
Study of the initial steps of the CD95-mediated signaling pathways is a field of intense research and a long list of actors has been described in the literature.
Gael Galli, Pierre Vacher, Bernhard Ryffel, Patrick Blanco, Patrick Legembre   +4 more
doaj   +2 more sources

SQSTM1/p62 at the Crossroads of Autophagy, Inflammation, and Lethal Infection [PDF]

Cells
Sequestosome 1 (SQSTM1, also known as p62) has emerged as a multifunctional signaling adaptor that bridges autophagy, proteostasis, and inflammation. In this review, we discuss the molecular mechanisms by which SQSTM1 regulates selective autophagy and ...
Ruoxi Zhang, Rui Kang, Daolin Tang
doaj   +2 more sources

Endogenous Damage-Associated Molecular Pattern Molecules at the Crossroads of Inflammation and Cancer

Neoplasia: An International Journal for Oncology Research, 2009
Inflammatory mediators play important roles in the development and progression of cancer. Cellular stress, damage, inflammation, and necrotic cell death cause release of endogenous damage-associated molecular pattern (DAMP) molecules or alarmins, which ...
Geetha Srikrishna, Hudson H. Freeze
doaj   +3 more sources

Damage-associated molecular patterns in hepatic ischemia–reperfusion injury: spatiotemporal signatures, biomarker potential, and clinical translation [PDF]

Frontiers in Immunology
Hepatic ischemia–reperfusion injury (HIRI) remains a key contributor to early allograft dysfunction (EAD), post-hepatectomy liver failure, biliary complications, and the underutilization of marginal donor grafts.
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
doaj   +2 more sources

Beyond Decellularization: Remnant Mitochondrial DNA Can Act as Hidden Damage-Associated Molecular Pattern [PDF]

Bioengineering
Tissue decellularization aims to obtain bioscaffolds for regenerative applications by removing all cellular components while preserving the extracellular matrix (ECM) architecture.
Elena V. A. van Hengel, Kuan Liu, Henk P. Roest, Jorke Willemse, Kimberley Ober-Vliegen, Selina M. W. Teurlings, Jeroen de Jonge, Monique M. A. Verstegen, Luc J. W. van der Laan   +8 more
doaj   +2 more sources

Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway. [PDF]

J Biol Chem, 2013
Edye ME, Lopez-Castejon G, Allan SM, Brough D.   +3 more
europepmc   +2 more sources

Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation

Cells, 2021
High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both stimulating and inhibiting innate immunity.
Ulf Andersson, Kevin J. Tracey, Huan Yang   +2 more
doaj   +1 more source

Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo

Frontiers in Immunology, 2020
Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt transport and protects the kidney from bacteria and stone formation.
Roland Immler, Bärbel Lange-Sperandio, Tobias Steffen, Heike Beck, Ina Rohwedder, Jonas Roth, Matteo Napoli, Georg Hupel, Frederik Pfister, Bastian Popper, Bastian Popper, Bernd Uhl, Bernd Uhl, Hanna Mannell, Christoph A. Reichel, Christoph A. Reichel, Volker Vielhauer, Jürgen Scherberich, Markus Sperandio, Monika Pruenster   +19 more
doaj   +1 more source

Arabinoxylan-Oligosaccharides Act as Damage Associated Molecular Patterns in Plants Regulating Disease Resistance

Frontiers in Plant Science, 2020
Immune responses in plants can be triggered by damage/microbe-associated molecular patterns (DAMPs/MAMPs) upon recognition by plant pattern recognition receptors (PRRs).
Hugo Mélida, Laura Bacete, Laura Bacete, Colin Ruprecht, Diego Rebaque, Diego Rebaque, Diego Rebaque, Irene del Hierro, Irene del Hierro, Gemma López, Frédéric Brunner, Fabian Pfrengle, Antonio Molina, Antonio Molina   +13 more
doaj   +1 more source