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Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis
Antioxidants & Redox Signaling, 2021Significance: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. This leads to an uncontrolled inflammatory response at the onset of infection, followed by immunosuppression. The development of a specific treatment modality for sepsis is still challenging, reflecting our inadequate understanding
Mian, Zhou, Monowar, Aziz, Ping, Wang
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Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses
Reviews in the Neurosciences, 2022Abstract The four core histones H2A, H2B, H3, H4, and the linker histone H1 primarily bind DNA and regulate gene expression within the nucleus. Evidence collected mainly from the peripheral tissues illustrates that histones can be released into the extracellular space by activated or damaged cells. In this article, we first summarize the
Christy M. Richards +3 more
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Damage-Associated Molecular Patterns and Systemic Signaling
Phytopathology®Cellular damage inflicted by wounding, pathogen infection, and herbivory releases a variety of host-derived metabolites, degraded structural components, and peptides into the extracellular space that act as alarm signals when perceived by adjacent cells.
Fiona M. Harris, Zhonglin Mou
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Damage‐associated molecular patterns and immune activation in bipolar disorder
Acta Psychiatrica Scandinavica, 2015ObjectiveImmune activation in bipolar disorder (BD) has been frequently reported. Damage‐associated molecular patterns (DAMPs) are key players in the immune activation reaction. The aim of this study was to assess DAMP levels in drug‐free patients with BD during acute episodes.MethodSerum levels of a predetermined set of DAMPs were assessed in drug ...
L, Stertz +10 more
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[Damage-associated molecular patterns and liver failure].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2017Damage-associated molecular patterns (DAMPs) are a series of intracellular molecules with immunoregulatory activity which are released by the damaged or activated cells and can induce autoimmunity or immune tolerance via pattern recognition receptors.
Y Y, Yan, S, Lin, Y Y, Zhu
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Mitochondrial damage‐associated molecular patterns in blood transfusion products
ISBT Science Series, 2017Mitochondria are organelles in charge of energy supply and the control of apoptosis. Owing to their similarities with bacteria, however, extracellular mitochondria are considered damage‐associated molecular patterns (DAMPs) capable of activating the immune system and non‐immune cells.
G. Marcoux, E. Boilard
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[DAMPs (damage-associated molecular patterns) and inflammation].
Nihon rinsho. Japanese journal of clinical medicine, 2016Post-ischemic inflammation is re-appraised as an important player in the progression of ischemic stroke. Activation of inflammatory cells via Toll-like receptor 2 (TLR2) and TLR4 is caused by several damage-associated molecular patterns (DAMPs), including high mobility group box-1 (HMGB-1) and heat shock proteins.
Hiroaki, Ooboshi, Takashi, Shichita
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Preeclampsia and damage — associated molecular patterns
Rossiiskii vestnik akushera-ginekologa, 2021V.I. Shcherbakov +2 more
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[Damage-associated molecular patterns and chronic diseases].
Sheng li ke xue jin zhan [Progress in physiology], 2012Molecules of damage-associated molecular patterns (DAMPs) are a class of substances released to intercellular space or peripheral blood by tissues or cells which are stimulated by insults, ischemia or stress. DAMP molecules can be recognized by Toll like receptors, Nod1-like receptors, or Rig-I like receptors and induce autoimmunity or immune tolerance,
Hong-Zhen, Yang +2 more
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Damage-associated molecular patterns and their pathological relevance in diabetes mellitus
Ageing Research Reviews, 2015Diabetes, a group of metabolic and age-related diseases, is a major global health problem, the incidence of which has increased dramatically in recent decades. Type 1 diabetes mellitus (T1DM) is a complex, T cell-mediated autoimmune disease characterized by immune cell infiltration and chronic inflammation in the islets of Langerhans.
Shin, Jung Jae +3 more
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