Results 21 to 30 of about 12,572 (254)

The Jasmonate-Responsive SmMPK3-SmWRKY33 Module Positively Regulates Tanshinone Biosynthesis in Salvia miltiorrhiza. [PDF]

Plant Biotechnol J
ABSTRACT Tanshinones, the major bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used to treat cardiovascular and cerebrovascular diseases. While jasmonates (JAs) are known to modulate tanshinones accumulation, the molecular link between JA signalling and tanshinone biosynthesis remains unclear.
Qu R, Wang S, Wang X, Peng J, Guo J, Cui G, Chen T, Chen M, Zhao S, Shen Y.   +9 more
europepmc   +2 more sources

Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice

Scientific Reports, 2021
With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low.
Le Su, Yue Su, Zaiyong An, Ping Zhang, Qiulin Yue, Chen Zhao, Xin Sun, Song Zhang, Xinli Liu, Kunlun Li, Lin Zhao   +10 more
doaj   +1 more source

Research and Development of Natural Product Tanshinone I: Pharmacology, Total Synthesis, and Structure Modifications

Frontiers in Pharmacology, 2022
Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble tanshinones in S.
Xing Huang, Lili Jin, Hao Deng, Dan Wu, Qing-kun Shen, Zhe-shan Quan, Chang-hao Zhang, Hong-Yan Guo   +7 more
doaj   +1 more source

A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets [PDF]

, 2017
published_or_final_versio
Cheung, F, Feng, Y, HONG, M, LI, S, Tan, HY, Wang, N   +5 more
core   +7 more sources

Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Huangqi-Danshen decoction (HDD), a Chinese herbal preparation, is effective in clinical treatment of chronic kidney disease (CKD). However, the underlying mechanism remains to be clarified.
Xi Huang, Liwen Gao, Ruyu Deng, Yu Peng, Shanshan Wu, Jiandong Lu, Xinhui Liu   +6 more
semanticscholar   +1 more source

Genome-Wide Characterization and Expression of the Hsf Gene Family in Salvia miltiorrhiza (Danshen) and the Potential Thermotolerance of SmHsf1 and SmHsf7 in Yeast

International Journal of Molecular Sciences, 2023
Salvia miltiorrhiza Bunge (Danshen) is a traditional Chinese herb with significant medicinal value. The yield and quality of Danshen are greatly affected by climatic conditions, in particular high temperatures.
R. Qu, Shiwei Wang, Xinxin Wang, Jiaming Peng, Juan Guo, Guanghong Cui, Mei-lan Chen, Jing Mu, Chang-jiang-sheng Lai, Luqi Huang, Sheng Wang, Ye Shen   +11 more
semanticscholar   +1 more source

Clinical effect of Danshen decoction in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

PLoS ONE, 2023
Background The incidence of heart failure (HF) is increasing year by year, posing a great threat to human health. Although pharmacotherapy has been able to significantly prolong patient survival, pharmacotherapy for HF still has limitations due to its ...
Ziyi Li, Mengnan Liu, Mingtai Chen, Gang Luo, Jiao Wu, Maryam Mazhar, Fang Yang, Yu Zheng, Hao Wu, Qibiao Wu, Sijin Yang   +10 more
semanticscholar   +1 more source

Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells

BMC Complementary and Alternative Medicine, 2017
Background Danshen is a common traditional Chinese medicine used to treat neoplastic and chronic inflammatory diseases in China. However, the effects of Danshen on human oral cancer cells remain relatively unknown.
Cheng-Yu Yang, Cheng-Chih Hsieh, Chih-Kung Lin, Chun-Shu Lin, Bo Peng, Gu-Jiun Lin, Huey-Kang Sytwu, Wen-Liang Chang, Yuan-Wu Chen   +8 more
doaj   +1 more source

Danshen (Salvia miltiorrhiza) injection suppresses kidney injury induced by iron overload in mice. [PDF]

PLoS ONE, 2013
OBJECTIVES: Excessive iron can accumulate in the kidney and induce tissue damage. Danshen (Salvia miltiorrhiza) injection is a traditional Chinese medicinal preparation used for preventing and treating chronic renal failure.
Shengjiang Guan, Juanjuan Ma, Ying Zhang, Yonggang Gao, Yuanyuan Zhang, Xuan Zhang, Na Wang, Yun Xie, Jiangyan Wang, Jianping Zhang, Li Chu   +10 more
doaj   +1 more source

Prevention of In-Stent Restenosis After PCI by Saponin Natural Products: Inhibition of Platelet Activation. [PDF]

J Cell Mol Med
ABSTRACT Percutaneous coronary intervention (PCI) enables coronary revascularisation and restores haemodynamic stability but also carries risks of delayed complications including in‐stent restenosis (ISR), a chronic progressive disease with endovascular damage after PCI, which compromises the long‐term efficacy of PCI.
Lei X, Lv C, Zhang Y, Li Z, Shen H, Zhu L.   +5 more
europepmc   +2 more sources