Results 121 to 130 of about 509,299 (294)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

naufalfano/itsfess_topicmodelling_LDA: ItsFess LDA Topic Modelling Dataset

, 2023
Muhammad Rifqi Hidayat, Naufal Firjatulloh Fano, Ribka Devina Margaretha, Zada Alfarras Rasendriya, Nur Aini Rakhmawati   +4 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Improving Suicidal Ideation Detection in Social Media Posts: Topic Modeling and Synthetic Data Augmentation Approach

JMIR Formative Research
BackgroundIn an era dominated by social media conversations, it is pivotal to comprehend how suicide, a critical public health issue, is discussed online.
Hamideh Ghanadian, Isar Nejadgholi, Hussein Al Osman   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A Multi-Faceted Approach to Trending Topic Attack Detection Using Semantic Similarity and Large-Scale Datasets

IEEE Access
Twitter’s widespread popularity has made it a prime target for malicious actors exploiting trending hashtags to disseminate harmful content. This study marks the first systematic exploration of semantic consistency in tweets to detect trending ...
Insaf Kraidia, Afifa Ghenai, Samir Brahim Belhaouari   +2 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Providing Citations to Support Fact-Checking: Contextualizing Detection of Sentences Needing Citation on Small Wikipedias

Natural Language Processing Journal
Authoritative citations are critical to ensure information integrity, especially in encyclopedias like Wikipedia. To date, research on automating citation worthiness detection has largely focused on the most resourceful language, English Wikipedia ...
Aida Halitaj, Arkaitz Zubiaga
doaj   +1 more source

Dataset of sensitive topics in Russian

, 2023
Nikolay, Varvara, Alexander Alexander
openalex   +2 more sources

Potrika: Raw and Balanced Newspaper Datasets in the Bangla Language with Eight Topics and Five Attributes [PDF]

, 2022
Istiak Ahmad, Fahad Alqurashi, Rashid Mehmood   +2 more
openalex   +1 more source