Results 101 to 110 of about 3,123 (186)
ChemistryEurope, Volume 3, Issue 6, November 11, 2025.Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling +5 more
wiley +1 more source
Dcp2 knock-down in the nervous system increases basal locomotor activity and blocks cNILH.
, 2012 A–E. The expression pattern of Dcp2GAL4 in the fly brain, visualized by mCD8::GFP. A nc82 antibody was used to visualize the neuropil. A–B. A projection view (A) and a cross-section (B) of a whole-mount brain. Scale bar represents 50 µm.
Jing Ren (107777) +6 more
core +1 more source
Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease
FASEB BioAdvances, Volume 7, Issue 11, November 2025.Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur +4 more
wiley +1 more source
RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins +5 more
wiley +1 more source
Comparison of XRN2 and DCP2 from eukaryotic organisms and E. histolytica.
, 2012 (A) A schematic representation of XRN2 protein from E. histolytica, H. sapiens and S. pombe. Red box: the XRN domain; cyan box: the tower domain (TD). The numbers are relative to the initial methionine in each protein. Lower panel: multiple alignments of
César López-Camarillo (90937) +9 more
core +1 more source
, 2022 A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Wu, Chan, Jacobson, Allan, He, Feng
core +1 more source
Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs
Viruses, 2017 All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of Rous sarcoma virus (RSV),
Vidya Balagopal, Karen L. Beemon
doaj +1 more source
, 2018 The RNA decapping enzyme Dcp2 is a crucial enzyme involved in the process of RNA turnover, which can post-transcriptionally regulate gene expression. Dcp2 has been found to be highly expressed in embryonic, but not adult, kidneys.
Ming-Nan Zhang +3 more
core +1 more source
DCP2 plays multiple roles during Drosophila development – possible case of moonlighting? [PDF]
, 2019 Abstract mRNA decapping proteins (DCPs) are components of the P-bodies in the cell which are hubs of mRNAs targeted for decay and they provide the cell with a reversible pool of mRNAs in response to cellular demands. The Drosophila genome codes for two decapping proteins, DCP1 and ...
Kunar, Rohit, Roy, Jagat K
openaire +1 more source
ERK-mediated phosphorylation of Dcp1a increases Dcp1a and Dcp2 association.
, 2013 (A) GFP-tagged Dcp1a, HA-tagged CA or DN MAPKK1 mutants, and Flag-tagged Dcp2 were co-expressed in HEK 293T cells. Protein complexes were immunoprecipitated using M2 beads. Inputs (50 µg of each cell extract) and immunoprecipitated protein complexes were
Yu-Lun Su (147369) +10 more
core +1 more source